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- W2160708580 abstract "The possibility that myo-inositol can substitute for or spare ascorbic acid in the diet of guinea pigs has been examined in three ways. First, inositol was given to adult guinea pigs subsisting on a vitamin C-deficient purified diet—to some from the beginning of the experiment, to others after scurvy had developed. Effects on the rate of onset of the disease, severity of the symptoms, and survival time were looked for. Second, essentially the same plan was followed with a scorbutigenic natural diet. And third, young guinea pigs were adapted to a purified diet, allowed to become scorbutic, then supplied with levels of ascorbic acid that ranged from suboptimal to sufficient. Some of the animals on each of these levels of ascorbic acid were also given inositol, and effects on the rate of recovery, survival, and rate of growth were looked for. Inositol did not have any detectable antiscorbutic activity in any of these experiments. At the start of the third experiment, while all of the guinea pigs were receiving the purified diet plus adequate vitamin C, the effect of adding inositol to the diet was tested. In keeping with the recent findings of other investigators (Reid, ’54) no growth stimulation was observed." @default.
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- W2160708580 date "1958-02-01" @default.
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- W2160708580 title "A Critical Evaluation of Myo-Inositol as an Ascorbic Acid-Sparing Agent" @default.
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- W2160708580 doi "https://doi.org/10.1093/jn/64.2.167" @default.
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