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- W2160728464 abstract "Abstract Synaptic membranes sequester calcium by a nonmitochondrial, ATP-dependent mechanism. This process appears to be important in maintaining low intrasynaptosomal levels of ionized calcium. In vitro addition of ethanol or pentobarbital to synaptic membranes isolated from mouse brain inhibited this ATP-dependent calcium uptake. Ethanol inhibited the uptake in a concentration-dependent manner over the range of 50–1600 mM. The inhibitory effects of low concentrations of ethanol were enhanced by a reduction in the ionized calcium concentration. The effects of even the highest concentration of ethanol were completely reversed when the drug was removed from the membranes. The effects of ethanol and pentobarbital were temperature dependent. The drugs produced a significant inhibition of uptake at assay temperatures of 23–37°, but not at assay temperatures of 1–18°. A single injection of ethanol inhibited the ATP-dependent sequestration of calcium and reduced the sensitivity of the isolated membranes to in vitro ethanol exposure, which suggests the development of an acute tolerance. Compared with membranes from control mice, membranes from mice that were chronically ingesting ethanol accumulated less calcium and were tolerant to the in vitro effects of ethanol and pentobarbital. These results suggest that the known stimulatory effects of ethanol and pentobarbital on the resting release of neurotransmitters, and the development of tolerance to these effects, may be due to alterations in the intrasynaptosomal sequestration of calcium." @default.
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- W2160728464 date "1981-12-01" @default.
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- W2160728464 title "Ethanol and pentobarbital inhibition of intrasynaptosomal sequestration of calcium" @default.
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- W2160728464 doi "https://doi.org/10.1016/0006-2952(81)90520-7" @default.
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