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- W2160731999 abstract "Introduction The amino acid glutamine (GLN) has received considerable attention as a potential therapeutic adjuvant in critical illness and in improving postoperative clinical outcomes. Most studies on the role of GLN in cellular physiology have historically focused on its anabolic roles in specific cell types and its contribution to growth in cancer cells. However, an emerging body of work that examines the consequences of GLN deprivation on cellular survival and gene expression has constructed a new paradigm for this amino acid, namely, that limited extracellular GLN supplies modulate stress and apoptotic responses. Methods A survey of the scientific literature was conducted on GLN in cell survival signaling and apoptosis. Work from our laboratory in liver cancer cells also was included in this review. Results Most studies on this topic have used mammalian cell lines derived from the gut, immune system (including hybridomas), and various cancers. GLN limitation, even in the presence of an adequate glucose supply, impacts stress-related gene expression, differentially modulates receptor-mediated apoptosis, and directly elicits apoptosis through signaling mechanisms and caspase cascades that are specific to cell type. To date, GLN transporters, cellular hydration, glutaminyl-tRNA synthetase, ATP levels, mRNA stability, and glutathione economy have been variably implicated in GLN-dependent survival signaling. Conclusion The cell type-specific mechanisms underlying the regulatory role of GLN in cell survival continue to unfold at a steady pace through in vitro studies. These results have collectively provided testable hypotheses for further in vivo studies into their physiological relevance during GLN “nutritional pharmacology.”" @default.
- W2160731999 created "2016-06-24" @default.
- W2160731999 creator A5045005400 @default.
- W2160731999 creator A5068858118 @default.
- W2160731999 date "2006-03-01" @default.
- W2160731999 modified "2023-09-27" @default.
- W2160731999 title "Stressing Out Over Survival: Glutamine as an Apoptotic Modulator" @default.
- W2160731999 cites W1243294255 @default.
- W2160731999 cites W1483212110 @default.
- W2160731999 cites W1506642042 @default.
- W2160731999 cites W1591022300 @default.
- W2160731999 cites W1596308403 @default.
- W2160731999 cites W1607595440 @default.
- W2160731999 cites W1607777232 @default.
- W2160731999 cites W1658568866 @default.
- W2160731999 cites W1745634660 @default.
- W2160731999 cites W1816748024 @default.
- W2160731999 cites W1836071808 @default.
- W2160731999 cites W1845459216 @default.
- W2160731999 cites W1861749169 @default.
- W2160731999 cites W1891967301 @default.
- W2160731999 cites W1904225901 @default.
- W2160731999 cites W1913519730 @default.
- W2160731999 cites W1935980275 @default.
- W2160731999 cites W1940692702 @default.
- W2160731999 cites W1940949702 @default.
- W2160731999 cites W1964617786 @default.
- W2160731999 cites W1964699291 @default.
- W2160731999 cites W1965261736 @default.
- W2160731999 cites W1968467968 @default.
- W2160731999 cites W1970515503 @default.
- W2160731999 cites W1970991025 @default.
- W2160731999 cites W1971851714 @default.
- W2160731999 cites W1972358035 @default.
- W2160731999 cites W1972806358 @default.
- W2160731999 cites W1973808108 @default.
- W2160731999 cites W1976229832 @default.
- W2160731999 cites W1977762705 @default.
- W2160731999 cites W1980754795 @default.
- W2160731999 cites W1980921389 @default.
- W2160731999 cites W1981106016 @default.
- W2160731999 cites W1981781943 @default.
- W2160731999 cites W1984417766 @default.
- W2160731999 cites W1986088387 @default.
- W2160731999 cites W1986568749 @default.
- W2160731999 cites W1988970110 @default.
- W2160731999 cites W1991774293 @default.
- W2160731999 cites W1991886593 @default.
- W2160731999 cites W1994505407 @default.
- W2160731999 cites W1995490493 @default.
- W2160731999 cites W1996180957 @default.
- W2160731999 cites W1997879915 @default.
- W2160731999 cites W1998651979 @default.
- W2160731999 cites W2002507218 @default.
- W2160731999 cites W2004942497 @default.
- W2160731999 cites W2006819816 @default.
- W2160731999 cites W2013688192 @default.
- W2160731999 cites W2016988197 @default.
- W2160731999 cites W2018184592 @default.
- W2160731999 cites W2022556843 @default.
- W2160731999 cites W2024533880 @default.
- W2160731999 cites W2024834748 @default.
- W2160731999 cites W2024873594 @default.
- W2160731999 cites W2025128734 @default.
- W2160731999 cites W2025511820 @default.
- W2160731999 cites W2028331558 @default.
- W2160731999 cites W2030522563 @default.
- W2160731999 cites W2032458681 @default.
- W2160731999 cites W2033624802 @default.
- W2160731999 cites W2034591877 @default.
- W2160731999 cites W2035368305 @default.
- W2160731999 cites W2035972383 @default.
- W2160731999 cites W2036747686 @default.
- W2160731999 cites W2037229599 @default.
- W2160731999 cites W2038055601 @default.
- W2160731999 cites W2038310727 @default.
- W2160731999 cites W2042779695 @default.
- W2160731999 cites W2045774364 @default.
- W2160731999 cites W2046639009 @default.
- W2160731999 cites W2048238764 @default.
- W2160731999 cites W2050988968 @default.
- W2160731999 cites W2052853635 @default.
- W2160731999 cites W2052896018 @default.
- W2160731999 cites W2053387982 @default.
- W2160731999 cites W2053654911 @default.
- W2160731999 cites W2054260525 @default.
- W2160731999 cites W2054820743 @default.
- W2160731999 cites W2055712486 @default.
- W2160731999 cites W2056376534 @default.
- W2160731999 cites W2058439257 @default.
- W2160731999 cites W2058845639 @default.
- W2160731999 cites W2059325107 @default.
- W2160731999 cites W2060218358 @default.
- W2160731999 cites W2061354386 @default.
- W2160731999 cites W2061497413 @default.
- W2160731999 cites W2062541508 @default.
- W2160731999 cites W2063619010 @default.
- W2160731999 cites W2066282812 @default.