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• W2160803541 abstract "Aims To identify specific positive immunohistochemical markers for spermatocytic seminoma ( SS ). Methods and results We studied the reactivity of 94 (total) cases of SS , seminoma, embryonal carcinoma and solid yolk sac tumour with antibodies against nuclear protein in testis ( NUT ) and two cancer/testis antigens, GAGE 7 and NY ‐ ESO ‐1. When tumour positivity was defined as an extent plus intensity score of ≥4, NUT was positive in 71% of SS s, 19% of seminomas, and 5% of solid yolk sac tumours. GAGE 7 was positive in 67% of SS s and 4% of seminomas. NY ‐ ESO ‐1 was positive in 82% of SS s, 13% of seminomas, and 5% of solid yolk sac tumours. The sensitivity and specificity, respectively, of these antibodies for SS s were as follows: NUT , 71% and 92%; GAGE 7, 67% and 99%; and NY ‐ ESO ‐1, 82% and 94%. When positivity criteria were stricter, NUT and GAGE 7 positivity occurred exclusively in SS , but the sensitivity decreased to 41% and 60%, respectively, and NY ‐ ESO ‐1 was 59% sensitive and 97% specific. Neither the sarcomatous component of three SS s nor any embryonal carcinoma showed reactivity with any antibody. Conclusions All three antibodies are variably sensitive for SS , and high specificity is attained when there is multifocal and strong nuclear labelling." @default.
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• W2160803541 date "2014-02-28" @default.
• W2160803541 modified "2023-10-04" @default.
• W2160803541 title "The utility of immunostaining for NUT, GAGE7 and NY-ESO-1 in the diagnosis of spermatocytic seminoma" @default.
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• W2160803541 doi "https://doi.org/10.1111/his.12365" @default.
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