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- W2160819951 abstract "Injections of p-chloroamphetamine (PCA, 5 mg/kg) induced hypothermia, ejaculation, salivation and irritability in male rats kept at an ambient temperature of 20±1°C. PCA-induced hypothermia was attenuated by pretreatment with the 5-hydroxytryptamine (5-HT) uptake blockers Lundbeck 10–171 (Lu 10–171, 10 mg/kg) and chlorimipramine (CMI, 20 mg/kg) and the 5-HT synthesis inhibitor parachlorophenylalanine (PCPA, 150 mg/kg daily for 3 days); it was potentiated by pretreatment with the noradrenaline uptake blocker Lundbeck 5-003 (Lu 5-003, 10 mg/kg) and the catecholamine synthesis inhibitor alpha-methyl-p-tyrosine (AMPT, 50 mg/kg every 3 hr for 9 hr). PCA-induced ejaculation was attenuated by pretreatment with Lu 10–171 and CMI. PCA-induced salivation was attenuated by pretreatment with Lu 10–171 and CMI and potentiated by pretreatment with Lu 5-003. PCA-induced irritability was potentiated by pretreatment with PCPA. These results suggest that both 5-HT and the catecholamines play a role in PCA-induced hypothermia, ejaculation, and salivation." @default.
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- W2160819951 title "Mechanisms of PCA-induced hypothermia, ejaculation, salivation and irritability in rats" @default.
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- W2160819951 doi "https://doi.org/10.1016/0091-3057(81)90177-5" @default.
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