FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160834723> ?p ?o ?g. }

• W2160834723 endingPage "12551" @default.
• W2160834723 startingPage "12541" @default.
• W2160834723 abstract "Variation of core amino acid (aa) 70 of hepatitis C virus (HCV) has been shown recently to be closely correlated with liver disease progression, suggesting that the core region might be present as a quasispecies during persistent infection and that this quasispecies nature might have an influence on the progression of disease. In our investigation, the subjects were 79 patients infected with HCV genotype 1b (25 with chronic hepatitis [CH], 29 with liver cirrhosis [LC], and 25 with hepatocellular carcinoma [HCC]). Deep sequencing of the HCV core region was carried out on their sera by using a Roche 454 GS Junior pyrosequencer. Based on a plasmid containing a cloned HCV sequence (pCV-J4L6S), the background error rate associated with pyrosequencing, including the PCR procedure, was calculated as 0.092 ± 0.005/base. Deep sequencing of the core region in the clinical samples showed a mixture of mutant-type Q/H and wild-type R at the core aa 70 position in most cases (71/79 [89.9%]), and the ratio of mutant residues to R in the mixture increased as liver disease advanced to LC and HCC. Meanwhile, phylogenetic analysis of the almost-complete core region revealed that the HCV isolates differed genetically depending on the mutation status at core aa 70. We conclude that the core aa 70 mixture ratio, determined by deep sequencing, reflected the status of liver disease, demonstrating a significant association between core aa 70 and disease progression in CH patients infected with HCV genotype 1b." @default.
• W2160834723 created "2016-06-24" @default.
• W2160834723 creator A5001895232 @default.
• W2160834723 creator A5003573363 @default.
• W2160834723 creator A5008040750 @default.
• W2160834723 creator A5008196968 @default.
• W2160834723 creator A5008540110 @default.
• W2160834723 creator A5010668249 @default.
• W2160834723 creator A5011874052 @default.
• W2160834723 creator A5018951423 @default.
• W2160834723 creator A5034439906 @default.
• W2160834723 creator A5038192407 @default.
• W2160834723 creator A5042327745 @default.
• W2160834723 creator A5056047067 @default.
• W2160834723 creator A5058386183 @default.
• W2160834723 creator A5075186900 @default.
• W2160834723 date "2013-12-01" @default.
• W2160834723 modified "2023-10-11" @default.
• W2160834723 title "Deep-Sequencing Analysis of the Association between the Quasispecies Nature of the Hepatitis C Virus Core Region and Disease Progression" @default.
• W2160834723 cites W1964557233 @default.
• W2160834723 cites W1968603331 @default.
• W2160834723 cites W1986293653 @default.
• W2160834723 cites W1986564802 @default.
• W2160834723 cites W1990958500 @default.
• W2160834723 cites W2000072710 @default.
• W2160834723 cites W2006075206 @default.
• W2160834723 cites W2007173319 @default.
• W2160834723 cites W2011221934 @default.
• W2160834723 cites W2017013905 @default.
• W2160834723 cites W2025212276 @default.
• W2160834723 cites W2026614040 @default.
• W2160834723 cites W2037251110 @default.
• W2160834723 cites W2053978445 @default.
• W2160834723 cites W2063285149 @default.
• W2160834723 cites W2072271760 @default.
• W2160834723 cites W2075293916 @default.
• W2160834723 cites W2075660007 @default.
• W2160834723 cites W2086414517 @default.
• W2160834723 cites W2088974319 @default.
• W2160834723 cites W2089122537 @default.
• W2160834723 cites W2103643894 @default.
• W2160834723 cites W2107791782 @default.
• W2160834723 cites W2118462385 @default.
• W2160834723 cites W2119371081 @default.
• W2160834723 cites W2132632499 @default.
• W2160834723 cites W2135249375 @default.
• W2160834723 cites W2135632998 @default.
• W2160834723 cites W2143532036 @default.
• W2160834723 cites W2152320056 @default.
• W2160834723 cites W2161266454 @default.
• W2160834723 cites W2166323995 @default.
• W2160834723 doi "https://doi.org/10.1128/jvi.00826-13" @default.
• W2160834723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3838162" @default.
• W2160834723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23946458" @default.
• W2160834723 hasPublicationYear "2013" @default.
• W2160834723 type Work @default.
• W2160834723 sameAs 2160834723 @default.
• W2160834723 citedByCount "31" @default.
• W2160834723 countsByYear W21608347232014 @default.
• W2160834723 countsByYear W21608347232015 @default.
• W2160834723 countsByYear W21608347232016 @default.
• W2160834723 countsByYear W21608347232017 @default.
• W2160834723 countsByYear W21608347232018 @default.
• W2160834723 countsByYear W21608347232019 @default.
• W2160834723 countsByYear W21608347232020 @default.
• W2160834723 countsByYear W21608347232021 @default.
• W2160834723 countsByYear W21608347232022 @default.
• W2160834723 countsByYear W21608347232023 @default.
• W2160834723 crossrefType "journal-article" @default.
• W2160834723 hasAuthorship W2160834723A5001895232 @default.
• W2160834723 hasAuthorship W2160834723A5003573363 @default.
• W2160834723 hasAuthorship W2160834723A5008040750 @default.
• W2160834723 hasAuthorship W2160834723A5008196968 @default.
• W2160834723 hasAuthorship W2160834723A5008540110 @default.
• W2160834723 hasAuthorship W2160834723A5010668249 @default.
• W2160834723 hasAuthorship W2160834723A5011874052 @default.
• W2160834723 hasAuthorship W2160834723A5018951423 @default.
• W2160834723 hasAuthorship W2160834723A5034439906 @default.
• W2160834723 hasAuthorship W2160834723A5038192407 @default.
• W2160834723 hasAuthorship W2160834723A5042327745 @default.
• W2160834723 hasAuthorship W2160834723A5056047067 @default.
• W2160834723 hasAuthorship W2160834723A5058386183 @default.
• W2160834723 hasAuthorship W2160834723A5075186900 @default.
• W2160834723 hasBestOaLocation W21608347231 @default.
• W2160834723 hasConcept C104317684 @default.
• W2160834723 hasConcept C125009961 @default.
• W2160834723 hasConcept C135763542 @default.
• W2160834723 hasConcept C14500911 @default.
• W2160834723 hasConcept C159047783 @default.
• W2160834723 hasConcept C2522874641 @default.
• W2160834723 hasConcept C2776408679 @default.
• W2160834723 hasConcept C2776455275 @default.
• W2160834723 hasConcept C2777075537 @default.
• W2160834723 hasConcept C2777214474 @default.
• W2160834723 hasConcept C2778019345 @default.
• W2160834723 hasConcept C2779102576 @default.
• W2160834723 hasConcept C54355233 @default.
• W2160834723 hasConcept C55493867 @default.

• next