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- W2160855812 abstract "Calcium/calmodulin-dependent protein kinase IV (CaMKIV) has been implicated in the regulation of CRE-dependent transcription. To investigate the role of this kinase in neuronal plasticity and memory, we generated transgenic mice in which the expression of a dominant-negative form of CaMKIV (dnCaMKIV) is restricted to the postnatal forebrain. In these transgenic mice, activity-induced CREB phosphorylation and c-Fos expression were significantly attenuated. Hippocampal late LTP (L-LTP) was also impaired, whereas basic synaptic function and early LTP (E-LTP) were unaffected. These deficits correlated with impairments in long-term memory, specifically in its consolidation/retention phase but not in the acquisition phase. These results indicate that neural activity-dependent CaMKIV signaling in the neuronal nucleus plays an important role in the consolidation/retention of hippocampus-dependent long-term memory." @default.
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- W2160855812 date "2001-09-01" @default.
- W2160855812 modified "2023-10-14" @default.
- W2160855812 title "An Important Role of Neural Activity-Dependent CaMKIV Signaling in the Consolidation of Long-Term Memory" @default.
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- W2160855812 doi "https://doi.org/10.1016/s0092-8674(01)00497-4" @default.
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