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• W2160866218 abstract "<h3>BACKGROUND:</h3> Severe exertional dyspnea is a commonly reported symptom in patients with COPD, especially in the advanced stages. Our objective was to assess the preliminary impact of comprehensive, individualized management provided by a specialized tertiary center clinic on exertional dyspnea and patient-centered outcomes in patients with advanced COPD. <h3>METHODS:</h3> This retrospective analysis included 45 subjects with COPD who were evaluated in a newly established dyspnea clinic over 3 years. Those with severe exertional dyspnea (Medical Research Council dyspnea score of ≥4/5), despite optimal disease-targeted therapy were eligible for referral. We used the revised Edmonton Symptom Assessment System (ESAS-r) to assess symptoms. Responders were defined as those whose change from baseline to 2-months met the minimum clinically important difference of ≤−1 in ESAS-r score for shortness of breath. <h3>RESULTS:</h3> Subjects (mean ± SD age 70 ± 7 years) had an average FEV₁ of 36 ± 18% predicted and a Medical Research Council dyspnea score of 4.7 ± 0.4. Responses to the intervention were variable and mean change in the ESAS-r score for shortness of breath in the total group was −0.32 ± 3.39, <i>P</i> = .53. Forty-seven percent of the subjects were identified as responders, and 42, 40, 40, and 33% met the minimum clinically important difference for improvement in ESAS-r scores for tiredness, anxiety, well-being, and depression, respectively. Responders had fewer emergency department annual visits in the 2 years after their first clinic visit compared with nonresponders (mean ± SD, 1.38 ± 1.63 vs 4.45 ± 5.52, <i>P</i> = .034). <h3>CONCLUSIONS:</h3> Although the impact of our specialized advanced dyspnea clinic was variable, as evaluated by the ESAS-r, it provided measurable additional clinically important benefit to almost half of the subjects with advanced COPD and severe refractory dyspnea." @default.
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• W2160866218 date "2009-07-28" @default.
• W2160866218 modified "2023-09-28" @default.
• W2160866218 title "Effectiveness of a health promotion programme for long-term unemployed subjects with health problems: a randomised controlled trial" @default.
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• W2160866218 doi "https://doi.org/10.1136/jech.2008.080432" @default.
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