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• W2160869897 abstract "The effect of doping a porous bioinert bioceramic with silicon (Si) on tissue ingrowth, differentiation, and osteogenesis was studied using a rat intramedullary model. Alumina tubes (1.3-mm outer diameter, 0.6-mm inner diameter, 15-mm length) doped with Si at nominal concentrations of 0.5 and 5.0 mol % were implanted into femoral medullary canals of female rats for 16 weeks. Tissue formation within the tubes was determined by histology and histomorphometry. Addition of 0.5 mol % Si to alumina stimulated cellular activity at the bone-ceramic interface and impaired osteogenic maturation within the tubes. In contrast, osteogenesis was enhanced in the 5.0 mol % Si-doped alumina tubes. It is considered that effect of Si is related to surface chemistry rather than microstructure. This work demonstrates that doping a bioinert ceramic with small amounts of Si can significantly alter tissue ingrowth, differentiation, and osteogenesis within a porous implant." @default.
• W2160869897 created "2016-06-24" @default.
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• W2160869897 date "2004-01-01" @default.
• W2160869897 modified "2023-09-25" @default.
• W2160869897 title "Effect of silicon doping on bone formation within alumina porous domains" @default.
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• W2160869897 doi "https://doi.org/10.1002/jbm.a.30154" @default.
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