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- W2160896781 endingPage "902" @default.
- W2160896781 startingPage "885" @default.
- W2160896781 abstract "ABSTRACT TLRs play a major role in microbe-host interactions and innate immunity. Of the 10 functional TLRs described in humans, TLR2 is unique in its requirement to form heterodimers with TLR1 or TLR6 for the initiation of signaling and cellular activation. The ligand specificity of TLR2 heterodimers has been studied extensively, using specific bacterial and synthetic lipoproteins to gain insight into the structure-function relationship, the minimal active motifs, and the critical dependence on TLR1 or TLR6 for activation. Different from that for specific well-defined TLR2 agonists, recognition of more complex ligands like intact microbes or molecules from endogenous origin requires TLR2 to interact with additional coreceptors. A breadth of data has been published on ligand-induced interactions of TLR2 with additional pattern recognition receptors such as CD14, scavenger receptors, integrins, and a range of other receptors, all of them important factors in TLR2 function. This review summarizes the roles of TLR2 in vivo and in specific immune cell types and integrates this information with a detailed review of our current understanding of the roles of specific coreceptors and ligands in regulating TLR2 functions. Understanding how these processes affect intracellular signaling and drive functional immune responses will lead to a better understanding of host-microbe interactions and will aid in the design of new agents to target TLR2 function in health and disease." @default.
- W2160896781 created "2016-06-24" @default.
- W2160896781 creator A5017111457 @default.
- W2160896781 creator A5023267835 @default.
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- W2160896781 creator A5052916600 @default.
- W2160896781 creator A5057480377 @default.
- W2160896781 creator A5069227141 @default.
- W2160896781 creator A5069659223 @default.
- W2160896781 date "2013-11-01" @default.
- W2160896781 modified "2023-10-05" @default.
- W2160896781 title "TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors" @default.
- W2160896781 cites W1490802705 @default.
- W2160896781 cites W1504160997 @default.
- W2160896781 cites W1529804111 @default.
- W2160896781 cites W1568763343 @default.
- W2160896781 cites W1576071600 @default.
- W2160896781 cites W1576773659 @default.
- W2160896781 cites W1579469490 @default.
- W2160896781 cites W1587466092 @default.
- W2160896781 cites W1590936677 @default.
- W2160896781 cites W1615242172 @default.
- W2160896781 cites W1627009127 @default.
- W2160896781 cites W1640299414 @default.
- W2160896781 cites W1655860314 @default.
- W2160896781 cites W1763730538 @default.
- W2160896781 cites W1848628272 @default.
- W2160896781 cites W1872552981 @default.
- W2160896781 cites W1876442176 @default.
- W2160896781 cites W1893091919 @default.
- W2160896781 cites W1897249974 @default.
- W2160896781 cites W1944075987 @default.
- W2160896781 cites W1957941154 @default.
- W2160896781 cites W1965918638 @default.
- W2160896781 cites W1966210473 @default.
- W2160896781 cites W1967269498 @default.
- W2160896781 cites W1967434989 @default.
- W2160896781 cites W1967944064 @default.
- W2160896781 cites W1968247416 @default.
- W2160896781 cites W1968769778 @default.
- W2160896781 cites W1970483666 @default.
- W2160896781 cites W1973353696 @default.
- W2160896781 cites W1973425514 @default.
- W2160896781 cites W1974738011 @default.
- W2160896781 cites W1974829145 @default.
- W2160896781 cites W1975146958 @default.
- W2160896781 cites W1975539423 @default.
- W2160896781 cites W1975840650 @default.
- W2160896781 cites W1976992284 @default.
- W2160896781 cites W1977957999 @default.
- W2160896781 cites W1978369960 @default.
- W2160896781 cites W1980082736 @default.
- W2160896781 cites W1980213997 @default.
- W2160896781 cites W1982297066 @default.
- W2160896781 cites W1984512389 @default.
- W2160896781 cites W1985779248 @default.
- W2160896781 cites W1986500032 @default.
- W2160896781 cites W1986906914 @default.
- W2160896781 cites W1987925713 @default.
- W2160896781 cites W1988822418 @default.
- W2160896781 cites W1989241623 @default.
- W2160896781 cites W1990149403 @default.
- W2160896781 cites W1990908543 @default.
- W2160896781 cites W1993792235 @default.
- W2160896781 cites W1994108614 @default.
- W2160896781 cites W1996529632 @default.
- W2160896781 cites W1996540389 @default.
- W2160896781 cites W1996671942 @default.
- W2160896781 cites W1997696481 @default.
- W2160896781 cites W1999810216 @default.
- W2160896781 cites W1999907389 @default.
- W2160896781 cites W1999927488 @default.
- W2160896781 cites W2000787206 @default.
- W2160896781 cites W2002291183 @default.
- W2160896781 cites W2003381671 @default.
- W2160896781 cites W2003543730 @default.
- W2160896781 cites W2004524797 @default.
- W2160896781 cites W2004647500 @default.
- W2160896781 cites W2004888713 @default.
- W2160896781 cites W2004985996 @default.
- W2160896781 cites W2007427970 @default.
- W2160896781 cites W2007473864 @default.
- W2160896781 cites W2008311655 @default.
- W2160896781 cites W2008415419 @default.
- W2160896781 cites W2009577175 @default.
- W2160896781 cites W2011102827 @default.
- W2160896781 cites W2011753823 @default.
- W2160896781 cites W2011996716 @default.
- W2160896781 cites W2013184085 @default.
- W2160896781 cites W2016209020 @default.
- W2160896781 cites W2016432359 @default.
- W2160896781 cites W2016862474 @default.
- W2160896781 cites W2017067394 @default.
- W2160896781 cites W2017296879 @default.
- W2160896781 cites W2017341404 @default.
- W2160896781 cites W2018325317 @default.
- W2160896781 cites W2018557879 @default.