Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160902443> ?p ?o ?g. }
- W2160902443 endingPage "11029" @default.
- W2160902443 startingPage "11024" @default.
- W2160902443 abstract "Significance Ectopic clusters of immune cells that mimic the structure and function of secondary lymphoid organs are defined as tertiary lymphoid organs (TLOs). They have been observed at sites of chronic inflammation for decades, but their formation and function have remained enigmatic. TLOs are thought to contribute to disease pathogenesis by promoting autoreactive lymphocyte survival and autoantibody production. In this study we identify a novel role for the cytokine IL-22 in TLO development and biology. We provide evidence that IL-22 expression within TLOs is instrumental for the production of the lymphoid chemokines, chemokine (C-X-C motif) ligand 13 and chemokine (C-X-C motif) ligand 12, which in turn orchestrate B-cell clustering, lymphoid aggregation, and autoantibody production. Our data provide a strong rationale for targeting IL-22 in TLO-associated autoimmune diseases." @default.
- W2160902443 created "2016-06-24" @default.
- W2160902443 creator A5000051455 @default.
- W2160902443 creator A5000148303 @default.
- W2160902443 creator A5011141273 @default.
- W2160902443 creator A5019716566 @default.
- W2160902443 creator A5021403462 @default.
- W2160902443 creator A5035076142 @default.
- W2160902443 creator A5036706108 @default.
- W2160902443 creator A5044642567 @default.
- W2160902443 creator A5050503305 @default.
- W2160902443 creator A5055843130 @default.
- W2160902443 creator A5057803401 @default.
- W2160902443 creator A5062460496 @default.
- W2160902443 creator A5063277741 @default.
- W2160902443 creator A5063357547 @default.
- W2160902443 creator A5068299150 @default.
- W2160902443 creator A5079297779 @default.
- W2160902443 creator A5081277430 @default.
- W2160902443 creator A5084920681 @default.
- W2160902443 date "2015-08-18" @default.
- W2160902443 modified "2023-10-14" @default.
- W2160902443 title "IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs" @default.
- W2160902443 cites W1535831265 @default.
- W2160902443 cites W1546495242 @default.
- W2160902443 cites W1566522868 @default.
- W2160902443 cites W1707437505 @default.
- W2160902443 cites W1713693487 @default.
- W2160902443 cites W1748698773 @default.
- W2160902443 cites W1962875376 @default.
- W2160902443 cites W1979534728 @default.
- W2160902443 cites W1981684491 @default.
- W2160902443 cites W1994530174 @default.
- W2160902443 cites W1999795586 @default.
- W2160902443 cites W2001634461 @default.
- W2160902443 cites W2004016559 @default.
- W2160902443 cites W2012550268 @default.
- W2160902443 cites W2022039920 @default.
- W2160902443 cites W2024988150 @default.
- W2160902443 cites W2036217549 @default.
- W2160902443 cites W2037373867 @default.
- W2160902443 cites W2038131331 @default.
- W2160902443 cites W2046549492 @default.
- W2160902443 cites W2046637170 @default.
- W2160902443 cites W2050603521 @default.
- W2160902443 cites W2077157308 @default.
- W2160902443 cites W2082473379 @default.
- W2160902443 cites W2083837388 @default.
- W2160902443 cites W2084338775 @default.
- W2160902443 cites W2091658694 @default.
- W2160902443 cites W2091674262 @default.
- W2160902443 cites W2092194665 @default.
- W2160902443 cites W2099628018 @default.
- W2160902443 cites W2100631475 @default.
- W2160902443 cites W2101143483 @default.
- W2160902443 cites W2106464597 @default.
- W2160902443 cites W2115055179 @default.
- W2160902443 cites W2123170297 @default.
- W2160902443 cites W2124499950 @default.
- W2160902443 cites W2138879607 @default.
- W2160902443 cites W2145007980 @default.
- W2160902443 cites W2145634436 @default.
- W2160902443 cites W2147022432 @default.
- W2160902443 cites W2154999756 @default.
- W2160902443 cites W2160805048 @default.
- W2160902443 cites W2169378111 @default.
- W2160902443 cites W2170270098 @default.
- W2160902443 cites W4236954136 @default.
- W2160902443 doi "https://doi.org/10.1073/pnas.1503315112" @default.
- W2160902443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4568258" @default.
- W2160902443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26286991" @default.
- W2160902443 hasPublicationYear "2015" @default.
- W2160902443 type Work @default.
- W2160902443 sameAs 2160902443 @default.
- W2160902443 citedByCount "160" @default.
- W2160902443 countsByYear W21609024432015 @default.
- W2160902443 countsByYear W21609024432016 @default.
- W2160902443 countsByYear W21609024432017 @default.
- W2160902443 countsByYear W21609024432018 @default.
- W2160902443 countsByYear W21609024432019 @default.
- W2160902443 countsByYear W21609024432020 @default.
- W2160902443 countsByYear W21609024432021 @default.
- W2160902443 countsByYear W21609024432022 @default.
- W2160902443 countsByYear W21609024432023 @default.
- W2160902443 crossrefType "journal-article" @default.
- W2160902443 hasAuthorship W2160902443A5000051455 @default.
- W2160902443 hasAuthorship W2160902443A5000148303 @default.
- W2160902443 hasAuthorship W2160902443A5011141273 @default.
- W2160902443 hasAuthorship W2160902443A5019716566 @default.
- W2160902443 hasAuthorship W2160902443A5021403462 @default.
- W2160902443 hasAuthorship W2160902443A5035076142 @default.
- W2160902443 hasAuthorship W2160902443A5036706108 @default.
- W2160902443 hasAuthorship W2160902443A5044642567 @default.
- W2160902443 hasAuthorship W2160902443A5050503305 @default.
- W2160902443 hasAuthorship W2160902443A5055843130 @default.
- W2160902443 hasAuthorship W2160902443A5057803401 @default.
- W2160902443 hasAuthorship W2160902443A5062460496 @default.
- W2160902443 hasAuthorship W2160902443A5063277741 @default.