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• W2160908047 abstract "<h3>BACKGROUND</h3> Previous fluorescein angiographic studies have shown alterations in the macular microcirculation in patients with diabetes mellitus and arterial hypertension. In both diseases capillary blood velocity was reduced and capillary density decreased. These changes were more pronounced in diabetic patients. We have examined the influence of arterial hypertension in combination with diabetes mellitus. <h3>METHODS</h3> 62 patients with diabetes mellitus and arterial hypertension (group 1) were matched with patients with diabetes mellitus but without arterial hypertension (group 2, match criteria: ETDRS stage of retinopathy). In all subjects fluorescein angiograms were performed with a scanning laser ophthalmoscope. Macular capillary blood velocity (CBV), perifoveal intercapillary area (PIA), the coefficient of variation of both parameters, the area of the foveal avascular zone (FAZ), and the arteriovenous passage time (AVP) were assessed by digital image analysis. <h3>RESULTS</h3> Systolic and diastolic blood pressures were significantly increased in the patients with arterial hypertension (systolic p=0.0008; diastolic p=0.03). Neither dynamic measures (AVP: 1.64 (0.49) seconds (group 1), 1.72 (0.58) seconds (group 2); CBV: 1.98 (0.39) mm/s (group 1), 2.09 (0.43) mm/s (group 2)) nor morphological measures (PIA: 7985 (3137) μm² (group 1), 8338 (3376) μm²(group 2); FAZ: 0.319 (0.206) mm² (group 1), 0.363 (0.237) mm² (group 2)) were significantly different between the two groups of diabetic patients. <h3>CONCLUSION</h3> Arterial hypertension did not result in more severe macular capillary dropout than diabetes without hypertension. This might be explained by the fact that most of the patients were being treated with antihypertensive drugs." @default.
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• W2160908047 date "2000-12-01" @default.
• W2160908047 modified "2023-09-25" @default.
• W2160908047 title "Macular circulation in patients with diabetes mellitus with and without arterial hypertension" @default.
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• W2160908047 doi "https://doi.org/10.1136/bjo.84.12.1392" @default.
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