FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160942335> ?p ?o ?g. }

• W2160942335 endingPage "917" @default.
• W2160942335 startingPage "911" @default.
• W2160942335 abstract "The conformational properties of soluble α-synuclein, the primary protein found in patients with Parkinson's disease, are thought to play a key role in the structural transition to amyloid fibrils. In this work, we report that recombinant 100% N-terminal acetylated α-synuclein purified under mild physiological conditions presents as a primarily monomeric protein, and that the N-terminal acetyl group affects the transient secondary structure and fibril assembly rates of the protein. Residue-specific NMR chemical shift analysis indicates substantial increase in transient helical propensity in the first 9 N-terminal residues, as well as smaller long-range changes in residues 28-31, 43-46, and 50-66: regions in which the three familial mutations currently known to be causative of early onset disease are found. In addition, we show that the N-terminal acetylated protein forms fibrils that are morphologically similar to those formed from nonacetylated α-synuclein, but that their growth rates are slower. Our results highlight that N-terminal acetylation does not form significant numbers of dimers, tetramers, or higher molecular weight species, but does alter the conformational distributions of monomeric α-synuclein species in regions known to be important in metal binding, in association with membranes, and in regions known to affect fibril formation rates." @default.
• W2160942335 created "2016-06-24" @default.
• W2160942335 creator A5004645149 @default.
• W2160942335 creator A5036165542 @default.
• W2160942335 creator A5047782202 @default.
• W2160942335 creator A5073277649 @default.
• W2160942335 creator A5074934123 @default.
• W2160942335 creator A5077651403 @default.
• W2160942335 date "2012-06-11" @default.
• W2160942335 modified "2023-10-17" @default.
• W2160942335 title "N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer" @default.
• W2160942335 cites W1498088837 @default.
• W2160942335 cites W1965778124 @default.
• W2160942335 cites W1971579210 @default.
• W2160942335 cites W1977178833 @default.
• W2160942335 cites W1986580794 @default.
• W2160942335 cites W1986625112 @default.
• W2160942335 cites W2005876244 @default.
• W2160942335 cites W2006199861 @default.
• W2160942335 cites W2008254728 @default.
• W2160942335 cites W2015372665 @default.
• W2160942335 cites W2016403696 @default.
• W2160942335 cites W2026717532 @default.
• W2160942335 cites W2027783821 @default.
• W2160942335 cites W2037441494 @default.
• W2160942335 cites W2041134571 @default.
• W2160942335 cites W2045318395 @default.
• W2160942335 cites W2046073833 @default.
• W2160942335 cites W2050786534 @default.
• W2160942335 cites W2056626063 @default.
• W2160942335 cites W2059111747 @default.
• W2160942335 cites W2060328944 @default.
• W2160942335 cites W2070032023 @default.
• W2160942335 cites W2077881833 @default.
• W2160942335 cites W2091265794 @default.
• W2160942335 cites W2093931104 @default.
• W2160942335 cites W2108865709 @default.
• W2160942335 cites W2112153468 @default.
• W2160942335 cites W2114781123 @default.
• W2160942335 cites W2137639276 @default.
• W2160942335 cites W2144435948 @default.
• W2160942335 cites W2148225540 @default.
• W2160942335 cites W2150656456 @default.
• W2160942335 cites W2154712137 @default.
• W2160942335 cites W2156771958 @default.
• W2160942335 cites W2169657393 @default.
• W2160942335 cites W2170823043 @default.
• W2160942335 cites W2316981376 @default.
• W2160942335 cites W3047703793 @default.
• W2160942335 doi "https://doi.org/10.1002/pro.2088" @default.
• W2160942335 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3403430" @default.
• W2160942335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22573613" @default.
• W2160942335 hasPublicationYear "2012" @default.
• W2160942335 type Work @default.
• W2160942335 sameAs 2160942335 @default.
• W2160942335 citedByCount "157" @default.
• W2160942335 countsByYear W21609423352012 @default.
• W2160942335 countsByYear W21609423352013 @default.
• W2160942335 countsByYear W21609423352014 @default.
• W2160942335 countsByYear W21609423352015 @default.
• W2160942335 countsByYear W21609423352016 @default.
• W2160942335 countsByYear W21609423352017 @default.
• W2160942335 countsByYear W21609423352018 @default.
• W2160942335 countsByYear W21609423352019 @default.
• W2160942335 countsByYear W21609423352020 @default.
• W2160942335 countsByYear W21609423352021 @default.
• W2160942335 countsByYear W21609423352022 @default.
• W2160942335 countsByYear W21609423352023 @default.
• W2160942335 crossrefType "journal-article" @default.
• W2160942335 hasAuthorship W2160942335A5004645149 @default.
• W2160942335 hasAuthorship W2160942335A5036165542 @default.
• W2160942335 hasAuthorship W2160942335A5047782202 @default.
• W2160942335 hasAuthorship W2160942335A5073277649 @default.
• W2160942335 hasAuthorship W2160942335A5074934123 @default.
• W2160942335 hasAuthorship W2160942335A5077651403 @default.
• W2160942335 hasBestOaLocation W21609423351 @default.
• W2160942335 hasConcept C104317684 @default.
• W2160942335 hasConcept C119157956 @default.
• W2160942335 hasConcept C12554922 @default.
• W2160942335 hasConcept C136238340 @default.
• W2160942335 hasConcept C142724271 @default.
• W2160942335 hasConcept C166940927 @default.
• W2160942335 hasConcept C178790620 @default.
• W2160942335 hasConcept C179104552 @default.
• W2160942335 hasConcept C185592680 @default.
• W2160942335 hasConcept C27523624 @default.
• W2160942335 hasConcept C2777633098 @default.
• W2160942335 hasConcept C2778815515 @default.
• W2160942335 hasConcept C2779134260 @default.
• W2160942335 hasConcept C2779734285 @default.
• W2160942335 hasConcept C2781338088 @default.
• W2160942335 hasConcept C2781449126 @default.
• W2160942335 hasConcept C47701112 @default.
• W2160942335 hasConcept C521977710 @default.
• W2160942335 hasConcept C55493867 @default.
• W2160942335 hasConcept C71924100 @default.
• W2160942335 hasConcept C8010536 @default.
• W2160942335 hasConcept C86803240 @default.

• next