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- W2160947904 abstract "Seventy-seven children and adolescents with drug-resistant epilepsies received vigabatrin as add-on therapy for a median of 18 months (range 4-36 months) at a dose of 50 mg/kg/day divided in two doses; patients with spasms were given a maximum dose of 100 mg/kg/day. In 23 patients (29.9%), seizure frequency decreased by 50-100% and in 12 patients (15.6%) by 25-50%. The number of seizures remained unchanged in 34 patients (44.1%) and increased in seven (9.1%). Vigabatrin was most effective in cryptogenic and symptomatic partial seizures (39% and 43%, respectively), and in infantile spasms (25%). Adverse events occurred in 20 patients (26%), though they were generally mild and transient, suggesting that vigabatrin is well tolerated." @default.
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- W2160947904 date "1997-11-01" @default.
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- W2160947904 title "Vigabatrin as add-on therapy in children and adolescents with refractory epilepsy: an open trial" @default.
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- W2160947904 doi "https://doi.org/10.1016/s0387-7604(97)00063-6" @default.
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