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- W2160948775 abstract "The larval zebrafish is a model organism to study the neural circuitry underlying behavior. There exist, however, few examples of robust long-term memory. Here we describe a simple, unrestrained associative place-conditioning paradigm. We show that visual access to a group of conspecifics has rewarding properties for 6- to 8-day-old larval zebrafish. We use this social reward as an unconditioned stimulus and pair it with a distinct visual environment. After training, larvae exhibited spatial preference for the location previously paired with the social reward for up to 36 h, indicating that zebrafish larvae can exhibit long-term associative memory. Furthermore, incubation with a protein synthesis inhibitor or an NMDAR-antagonist impaired memory. In future experiments, this learning paradigm could be used to study the social interactions of larval zebrafish or paired with cell-specific metabolic labeling to visualize circuits underlying memory formation." @default.
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- W2160948775 date "2013-09-25" @default.
- W2160948775 modified "2023-10-13" @default.
- W2160948775 title "Protein Synthesis-Dependent Associative Long-Term Memory in Larval Zebrafish" @default.
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- W2160948775 doi "https://doi.org/10.1523/jneurosci.0560-13.2013" @default.
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