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• W2160971027 abstract "Rhinoviruses (RVs) are responsible for the majority of acute asthma and chronic obstructive pulmonary disease (COPD) exacerbations. RVs infect the lower airways and induce the production of pro-inflammatory and remodelling-associated mediators. Budesonide (BUD) and formoterol (FORM) synergize in controlling asthma and COPD exacerbations; however, their effects on virus-induced inflammation and remodelling are less known.We investigated whether BUD and FORM synergize in suppressing RV-induced inflammation and remodelling in the airways.In vitro models of RV infection of BEAS-2B and primary normal human bronchial epithelial (NHBE) cells were used. We assessed the effects of individual and combined drugs administered post-infection, at a clinically relevant concentration range (10(-6)-10(-10) m), on the production of CCL5, CXCL10, CXCL8, IL-6 and the remodelling-associated VEGF and bFGF, using ELISA and RT-PCR.BUD effectively suppressed RV-mediated induction of all mediators studied, in a concentration-dependent manner. FORM alone suppressed the production of CXCL8 and bFGF. The combination of BUD and FORM had concentration-dependent, additive or synergistic effects in the suppression of RV-induced CCL5, CXCL8 and CXCL10 in both cell types as well as VEGF in NHBE only. Combination treatment also resulted in an enhanced suppression of RV-induced IL-6, and CCL5 at the mRNA level as compared with BUD or FORM alone.BUD and FORM suppress RV-induced chemokines and growth factors in bronchial epithelial cells in a concentration-dependent, synergistic or additive manner. These data further support the combined use of BUD and FORM in asthma and COPD and intensification of this therapy during exacerbations." @default.
• W2160971027 created "2016-06-24" @default.
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• W2160971027 date "2009-11-01" @default.
• W2160971027 modified "2023-10-06" @default.
• W2160971027 title "Budesonide and formoterol inhibit inflammatory mediator production by bronchial epithelial cells infected with rhinovirus" @default.
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• W2160971027 doi "https://doi.org/10.1111/j.1365-2222.2009.03307.x" @default.
• W2160971027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19549024" @default.
• W2160971027 hasPublicationYear "2009" @default.
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