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• W2160992407 abstract "Phasic contractile activity in rat portal vein is more sensitive to the rate of change in length than to absolute length and this response is widely assumed to be a general characteristic of myogenic behaviour for vascular smooth muscle. Previously, we found that rat lymphatic vessels exhibit phasic contractile behaviour similar to that of portal vein. In the present study, we hypothesized that lymphatic muscle would exhibit rate‐sensitive contractile responses to stretch. The hypothesis was tested on rat mesenteric lymphatics (90–220 μm, i.d.) using servo‐controlled wire‐ and pressure‐myograph systems to enable ramp increases in force or pressure at different rates. Under isometric conditions in wire‐myograph preparations, both the amplitude and the frequency of phasic activity were enhanced at more optimal preloads, but superimposed upon this effect were bursts of contractions that occurred only during fast preload ramps. In such cases, the ratio of contraction frequency during the ramp to that at the subsequent plateau (at optimal preload) was > 1. Further, the frequency ratio increased as a function of the preload ramp speed, consistent with a rate‐sensitive mechanism. In contrast, the amplitude ratio was < 1 and declined further with higher ramp speeds. Downward preload ramps produced corresponding rate‐sensitive inhibition of contraction frequency but not amplitude. Similar findings were obtained in pressurized lymphatics in response to pressure ramps and steps. Our results suggest that lymphatics are sensitive to the rate of change in preload/pressure in a way that is different from portal vein, possibly because the pacemaker for generating electrical activity is rate sensitive but lymphatic muscle is not. The behaviour may be widely present in collecting lymphatic vessels and is probably an important mechanism for rapid adaptation of the lymphatic pump to local vascular occlusion." @default.
• W2160992407 created "2016-06-24" @default.
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• W2160992407 date "2009-01-01" @default.
• W2160992407 modified "2023-10-16" @default.
• W2160992407 title "Rate-sensitive contractile responses of lymphatic vessels to circumferential stretch" @default.
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• W2160992407 doi "https://doi.org/10.1113/jphysiol.2008.162438" @default.
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