FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2160996499> ?p ?o ?g. }

• W2160996499 endingPage "1249" @default.
• W2160996499 startingPage "1235" @default.
• W2160996499 abstract "This clinical study characterized nutritional lactate spikes, investigated their antagonism by dichloroacetate (DCA), quantitated that antagonism, and compared these with fasting lactate concentration responses. A secondary concern was the tolerability of DCA, including consequent oxaluria. We measured lactate and DCA concentrations simultaneously, using a double-blind, placebo-controlled protocol, and Schild analysis. Nutritional lactate spikes peaked at 2 mM, and lasted for about 2 h, and DCA was a non-competitive antagonist, with EC50 similar to that for reducing fasting lactate concentration. Oxaluria (up to 4-fold control) was complete by 24–36 h, linearly related to DCA dose, and without crystalluria. Conclusions: i) Nutritional lactate spikes are non-competitively antagonized by DCA (unlike exercise-induced spikes), ii) this is a method for comparison of pyruvate dehydrogenase activating drugs, and iii) consequent oxalate loads are well-tolerated." @default.
• W2160996499 created "2016-06-24" @default.
• W2160996499 creator A5021908648 @default.
• W2160996499 creator A5078582922 @default.
• W2160996499 creator A5085354635 @default.
• W2160996499 date "2001-09-01" @default.
• W2160996499 modified "2023-09-25" @default.
• W2160996499 title "Nutritional lactate spikes: quantitative antagonism by dichloroacetate" @default.
• W2160996499 cites W1481823467 @default.
• W2160996499 cites W1757455318 @default.
• W2160996499 cites W1759931938 @default.
• W2160996499 cites W1919352341 @default.
• W2160996499 cites W1971128106 @default.
• W2160996499 cites W1986088683 @default.
• W2160996499 cites W1987689160 @default.
• W2160996499 cites W1994148625 @default.
• W2160996499 cites W1997052254 @default.
• W2160996499 cites W1998211590 @default.
• W2160996499 cites W2001210046 @default.
• W2160996499 cites W2004857711 @default.
• W2160996499 cites W2010033336 @default.
• W2160996499 cites W2011119564 @default.
• W2160996499 cites W2013005050 @default.
• W2160996499 cites W2019263576 @default.
• W2160996499 cites W2019438997 @default.
• W2160996499 cites W2037675569 @default.
• W2160996499 cites W2044107877 @default.
• W2160996499 cites W2045377968 @default.
• W2160996499 cites W2057166414 @default.
• W2160996499 cites W2073742827 @default.
• W2160996499 cites W2094538969 @default.
• W2160996499 cites W2095032459 @default.
• W2160996499 cites W2107914283 @default.
• W2160996499 cites W2112299056 @default.
• W2160996499 cites W2117709992 @default.
• W2160996499 cites W2141629943 @default.
• W2160996499 cites W2144739553 @default.
• W2160996499 cites W2155334628 @default.
• W2160996499 cites W2165631575 @default.
• W2160996499 cites W2169766618 @default.
• W2160996499 cites W2188563884 @default.
• W2160996499 cites W2258201971 @default.
• W2160996499 cites W2331207879 @default.
• W2160996499 cites W2336950143 @default.
• W2160996499 cites W963000621 @default.
• W2160996499 cites W1989013008 @default.
• W2160996499 doi "https://doi.org/10.1016/s0271-5317(01)00339-6" @default.
• W2160996499 hasPublicationYear "2001" @default.
• W2160996499 type Work @default.
• W2160996499 sameAs 2160996499 @default.
• W2160996499 citedByCount "0" @default.
• W2160996499 crossrefType "journal-article" @default.
• W2160996499 hasAuthorship W2160996499A5021908648 @default.
• W2160996499 hasAuthorship W2160996499A5078582922 @default.
• W2160996499 hasAuthorship W2160996499A5085354635 @default.
• W2160996499 hasConcept C126322002 @default.
• W2160996499 hasConcept C134018914 @default.
• W2160996499 hasConcept C170493617 @default.
• W2160996499 hasConcept C181199279 @default.
• W2160996499 hasConcept C185592680 @default.
• W2160996499 hasConcept C197934379 @default.
• W2160996499 hasConcept C2775920511 @default.
• W2160996499 hasConcept C2776885963 @default.
• W2160996499 hasConcept C2777318727 @default.
• W2160996499 hasConcept C2777383412 @default.
• W2160996499 hasConcept C2778375690 @default.
• W2160996499 hasConcept C523546767 @default.
• W2160996499 hasConcept C54355233 @default.
• W2160996499 hasConcept C55493867 @default.
• W2160996499 hasConcept C71924100 @default.
• W2160996499 hasConcept C86803240 @default.
• W2160996499 hasConcept C98274493 @default.
• W2160996499 hasConceptScore W2160996499C126322002 @default.
• W2160996499 hasConceptScore W2160996499C134018914 @default.
• W2160996499 hasConceptScore W2160996499C170493617 @default.
• W2160996499 hasConceptScore W2160996499C181199279 @default.
• W2160996499 hasConceptScore W2160996499C185592680 @default.
• W2160996499 hasConceptScore W2160996499C197934379 @default.
• W2160996499 hasConceptScore W2160996499C2775920511 @default.
• W2160996499 hasConceptScore W2160996499C2776885963 @default.
• W2160996499 hasConceptScore W2160996499C2777318727 @default.
• W2160996499 hasConceptScore W2160996499C2777383412 @default.
• W2160996499 hasConceptScore W2160996499C2778375690 @default.
• W2160996499 hasConceptScore W2160996499C523546767 @default.
• W2160996499 hasConceptScore W2160996499C54355233 @default.
• W2160996499 hasConceptScore W2160996499C55493867 @default.
• W2160996499 hasConceptScore W2160996499C71924100 @default.
• W2160996499 hasConceptScore W2160996499C86803240 @default.
• W2160996499 hasConceptScore W2160996499C98274493 @default.
• W2160996499 hasIssue "9" @default.
• W2160996499 hasLocation W21609964991 @default.
• W2160996499 hasOpenAccess W2160996499 @default.
• W2160996499 hasPrimaryLocation W21609964991 @default.
• W2160996499 hasRelatedWork W1970208811 @default.
• W2160996499 hasRelatedWork W1988153710 @default.
• W2160996499 hasRelatedWork W2009389088 @default.
• W2160996499 hasRelatedWork W2029100518 @default.
• W2160996499 hasRelatedWork W2051270818 @default.

• next