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• W2161009372 endingPage "6632" @default.
• W2161009372 startingPage "6624" @default.
• W2161009372 abstract "Different mechanisms of transcriptional activation may be required for distinct classes of promoters and cellular conditions. The Epstein-Barr virus (EBV)-encoded transcriptional activator Zta recruits the general transcription factors IID (TFIID) and IIA (TFIIA) to promoter DNA and induces a TATA box-binding protein (TBP)-associated factor-dependent footprint downstream of the transcriptional initiation site. In this study, we investigated the functional significance of TFIID-TFIIA (D-A complex) recruitment by Zta. Alanine substitution mutations in the Zta activation domain which eliminate the ability of Zta to stimulate the D-A complex were examined. These Zta mutants were defective in the ability to activate transcription from an EBV-derived promoter (BHLF1) but activated a highly responsive synthetic promoter (Z7E4T). Both the number of activator binding sites and the core promoter region contribute to the requirement for D-A complex recruitment. These functionally distinct core promoters had significant differences in affinity for TBP and TFIID binding. The D-A complex-recruiting activity of Zta was found to be important for promoter selection in the presence of a competitor template. Conditions which limit TFIID binding to the TATA element or compromise the ability of TFIIA to bind TBP required activator stimulation of the D-A complex. These results indicate that D-A complex recruitment is one of at least two activation pathways utilized by Zta and is the essential pathway for a subset of promoters and conditions which limit TFIID binding to the TATA element." @default.
• W2161009372 created "2016-06-24" @default.
• W2161009372 creator A5054908983 @default.
• W2161009372 creator A5064384577 @default.
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• W2161009372 date "1997-11-01" @default.
• W2161009372 modified "2023-09-26" @default.
• W2161009372 title "Requirement for Transcription Factor IIA (TFIIA)-TFIID Recruitment by an Activator Depends on Promoter Structure and Template Competition" @default.
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• W2161009372 doi "https://doi.org/10.1128/mcb.17.11.6624" @default.
• W2161009372 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/232516" @default.
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• W2161009372 hasPublicationYear "1997" @default.
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