FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161036104> ?p ?o ?g. }

• W2161036104 endingPage "5265" @default.
• W2161036104 startingPage "5254" @default.
• W2161036104 abstract "ABSTRACT Toxoplasma gondii , an obligate intracellular parasite pathogen which initially invades the intestinal epithelium before disseminating throughout the body, may cause severe sequelae in fetuses and life-threatening neuropathy in immunocompromised patients. Immune protection is usually thought to be performed through a systemic Th1 response; considering the route of parasite entry it is important to study and characterize the local mucosal immune response to T. gondii . Despite considerable effort, Toxoplasma -targeted vaccines have proven to be elusive using conventional strategies. We report the use of mesenteric lymph node dendritic cells (MLNDCs) pulsed ex vivo with T. gondii antigens (TAg) as a novel investigation approach to vaccination against T. gondii -driven pathogenic processes. Using a murine model, we demonstrate in two genetically distinct mouse strains (C57BL/6 and CBA/J) that adoptively transferred TAg-pulsed MLNDCs elicit a mucosal Toxoplasma -specific Th2-biased immune response in vivo and confer strong protection against infection. We also observe that MLNDCs mostly traffic to the intestine where they enhance resistance by reduction in the mortality and in the number of brain cysts. Thus, ex vivo TAg-pulsed MLNDCs represent a powerful tool for the study of protective immunity to T. gondii , delivered through its natural route of entry. These findings might impact the design of vaccine strategies against other invasive microorganisms known to be delivered through digestive tract." @default.
• W2161036104 created "2016-06-24" @default.
• W2161036104 creator A5016096121 @default.
• W2161036104 creator A5044695098 @default.
• W2161036104 creator A5045353826 @default.
• W2161036104 creator A5059513386 @default.
• W2161036104 creator A5073920563 @default.
• W2161036104 creator A5087601737 @default.
• W2161036104 date "2003-09-01" @default.
• W2161036104 modified "2023-10-17" @default.
• W2161036104 title "Protective Mucosal Th2 Immune Response against<i>Toxoplasma gondii</i>by Murine Mesenteric Lymph Node Dendritic Cells" @default.
• W2161036104 cites W1507553134 @default.
• W2161036104 cites W1665796496 @default.
• W2161036104 cites W1875684041 @default.
• W2161036104 cites W1935566751 @default.
• W2161036104 cites W1936603815 @default.
• W2161036104 cites W1968274103 @default.
• W2161036104 cites W1972473113 @default.
• W2161036104 cites W1991062152 @default.
• W2161036104 cites W1998470464 @default.
• W2161036104 cites W2014530361 @default.
• W2161036104 cites W2027238003 @default.
• W2161036104 cites W2051055500 @default.
• W2161036104 cites W2054930447 @default.
• W2161036104 cites W2069869063 @default.
• W2161036104 cites W2083132664 @default.
• W2161036104 cites W2098679813 @default.
• W2161036104 cites W2100531615 @default.
• W2161036104 cites W2132709753 @default.
• W2161036104 cites W2138334533 @default.
• W2161036104 cites W2140117437 @default.
• W2161036104 cites W2155754332 @default.
• W2161036104 cites W2159389701 @default.
• W2161036104 cites W2165246436 @default.
• W2161036104 cites W2166676682 @default.
• W2161036104 cites W2168387989 @default.
• W2161036104 cites W2209894880 @default.
• W2161036104 cites W22267671 @default.
• W2161036104 cites W2442174845 @default.
• W2161036104 doi "https://doi.org/10.1128/iai.71.9.5254-5265.2003" @default.
• W2161036104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/187296" @default.
• W2161036104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12933872" @default.
• W2161036104 hasPublicationYear "2003" @default.
• W2161036104 type Work @default.
• W2161036104 sameAs 2161036104 @default.
• W2161036104 citedByCount "41" @default.
• W2161036104 countsByYear W21610361042012 @default.
• W2161036104 countsByYear W21610361042013 @default.
• W2161036104 countsByYear W21610361042014 @default.
• W2161036104 countsByYear W21610361042015 @default.
• W2161036104 countsByYear W21610361042016 @default.
• W2161036104 countsByYear W21610361042017 @default.
• W2161036104 countsByYear W21610361042018 @default.
• W2161036104 countsByYear W21610361042019 @default.
• W2161036104 countsByYear W21610361042020 @default.
• W2161036104 countsByYear W21610361042021 @default.
• W2161036104 countsByYear W21610361042022 @default.
• W2161036104 countsByYear W21610361042023 @default.
• W2161036104 crossrefType "journal-article" @default.
• W2161036104 hasAuthorship W2161036104A5016096121 @default.
• W2161036104 hasAuthorship W2161036104A5044695098 @default.
• W2161036104 hasAuthorship W2161036104A5045353826 @default.
• W2161036104 hasAuthorship W2161036104A5059513386 @default.
• W2161036104 hasAuthorship W2161036104A5073920563 @default.
• W2161036104 hasAuthorship W2161036104A5087601737 @default.
• W2161036104 hasBestOaLocation W21610361043 @default.
• W2161036104 hasConcept C150903083 @default.
• W2161036104 hasConcept C153726182 @default.
• W2161036104 hasConcept C159654299 @default.
• W2161036104 hasConcept C203014093 @default.
• W2161036104 hasConcept C207001950 @default.
• W2161036104 hasConcept C26291073 @default.
• W2161036104 hasConcept C2778128430 @default.
• W2161036104 hasConcept C2778170410 @default.
• W2161036104 hasConcept C2779237934 @default.
• W2161036104 hasConcept C2779341262 @default.
• W2161036104 hasConcept C2780849966 @default.
• W2161036104 hasConcept C2781077229 @default.
• W2161036104 hasConcept C529295009 @default.
• W2161036104 hasConcept C54355233 @default.
• W2161036104 hasConcept C86803240 @default.
• W2161036104 hasConcept C8891405 @default.
• W2161036104 hasConceptScore W2161036104C150903083 @default.
• W2161036104 hasConceptScore W2161036104C153726182 @default.
• W2161036104 hasConceptScore W2161036104C159654299 @default.
• W2161036104 hasConceptScore W2161036104C203014093 @default.
• W2161036104 hasConceptScore W2161036104C207001950 @default.
• W2161036104 hasConceptScore W2161036104C26291073 @default.
• W2161036104 hasConceptScore W2161036104C2778128430 @default.
• W2161036104 hasConceptScore W2161036104C2778170410 @default.
• W2161036104 hasConceptScore W2161036104C2779237934 @default.
• W2161036104 hasConceptScore W2161036104C2779341262 @default.
• W2161036104 hasConceptScore W2161036104C2780849966 @default.
• W2161036104 hasConceptScore W2161036104C2781077229 @default.
• W2161036104 hasConceptScore W2161036104C529295009 @default.
• W2161036104 hasConceptScore W2161036104C54355233 @default.
• W2161036104 hasConceptScore W2161036104C86803240 @default.
• W2161036104 hasConceptScore W2161036104C8891405 @default.

• next