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- W2161036292 abstract "Altered vasculature and the resultant chaotic tumor blood flow lead to the appearance in fast-growing tumors of regions with gradients of oxygen tension and acute hypoxia (less than 1.4 % oxygen).1 Due to its roles in tumorigenesis and resistance to therapy, hypoxia represents a problem in cancer therapy.1, 2 Insufficient delivery of therapeutic agents to the hypoxic regions in solid tumors is recognized as one of the causes of resistance to therapy.1, 3 This led to the development of hypoxia imaging agents,4 and the use of hypoxia-activated anticancer prodrugs.2a Here we show the first example of the hypoxia-induced siRNA uptake and silencing using a nanocarrier consisting of polyethyleneglycol 2000, azobenzene, polyethyleneimine (PEI)(1.8 kDa), and 1,2-dioleyl-sn-glycero-3-phosphoethanolamine (DOPE) units (the nanocarrier is referred to as PAPD), where azobenzene imparts hypoxia sensitivity and specificity.4a We report hypoxia-activated green fluorescent protein (GFP) silencing in vitro and its downregulation in GFP-expressing tumors after intravenous administration. The proposed nanoformulation represents a novel tumor-environment-responsive modality for cancer targeting and siRNA delivery." @default.
- W2161036292 created "2016-06-24" @default.
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- W2161036292 date "2014-02-19" @default.
- W2161036292 modified "2023-10-12" @default.
- W2161036292 title "Hypoxia-Targeted siRNA Delivery" @default.
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- W2161036292 doi "https://doi.org/10.1002/anie.201308368" @default.
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