Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161036636> ?p ?o ?g. }
- W2161036636 endingPage "225" @default.
- W2161036636 startingPage "213" @default.
- W2161036636 abstract "Incorporation of GluR1-containing AMPA receptors into synapses is essential to several forms of neural plasticity, including long-term potentiation (LTP). Numerous signaling pathways that trigger this process have been identified, but the direct modifications of GluR1 that control its incorporation into synapses are unclear. Here, we show that phosphorylation of GluR1 by PKC at a highly conserved serine 818 residue is increased during LTP and critical for LTP expression. GluR1 is phosphorylated by PKC at this site in vitro and in vivo. In addition, acute phosphorylation at GluR1 S818 by PKC, as well as a phosphomimetic mutation, promotes GluR1 synaptic incorporation. Conversely, preventing GluR1 S818 phosphorylation reduces LTP and blocks PKC-driven synaptic incorporation of GluR1. We conclude that the phosphorylation of GluR1 S818 by PKC is a critical event in the plasticity-driven synaptic incorporation of AMPA receptors." @default.
- W2161036636 created "2016-06-24" @default.
- W2161036636 creator A5019440310 @default.
- W2161036636 creator A5025530976 @default.
- W2161036636 creator A5026428336 @default.
- W2161036636 creator A5052448979 @default.
- W2161036636 creator A5059441599 @default.
- W2161036636 creator A5065713713 @default.
- W2161036636 date "2006-07-01" @default.
- W2161036636 modified "2023-10-10" @default.
- W2161036636 title "Synaptic Incorporation of AMPA Receptors during LTP Is Controlled by a PKC Phosphorylation Site on GluR1" @default.
- W2161036636 cites W1544008935 @default.
- W2161036636 cites W1563427807 @default.
- W2161036636 cites W1563827780 @default.
- W2161036636 cites W1565985941 @default.
- W2161036636 cites W1602103399 @default.
- W2161036636 cites W1604295762 @default.
- W2161036636 cites W1609834322 @default.
- W2161036636 cites W1725524769 @default.
- W2161036636 cites W1929828037 @default.
- W2161036636 cites W1964945221 @default.
- W2161036636 cites W1965211768 @default.
- W2161036636 cites W1965507972 @default.
- W2161036636 cites W1968881572 @default.
- W2161036636 cites W1970917461 @default.
- W2161036636 cites W1978155331 @default.
- W2161036636 cites W1979586675 @default.
- W2161036636 cites W1993049854 @default.
- W2161036636 cites W1993135690 @default.
- W2161036636 cites W1993968078 @default.
- W2161036636 cites W1995680954 @default.
- W2161036636 cites W1998961469 @default.
- W2161036636 cites W2010920096 @default.
- W2161036636 cites W2012678641 @default.
- W2161036636 cites W2016425872 @default.
- W2161036636 cites W2017197432 @default.
- W2161036636 cites W2018775189 @default.
- W2161036636 cites W2022513417 @default.
- W2161036636 cites W2022924617 @default.
- W2161036636 cites W2031104034 @default.
- W2161036636 cites W2031635859 @default.
- W2161036636 cites W2035082265 @default.
- W2161036636 cites W2036869107 @default.
- W2161036636 cites W2047981012 @default.
- W2161036636 cites W2051473177 @default.
- W2161036636 cites W2052322593 @default.
- W2161036636 cites W2056550783 @default.
- W2161036636 cites W2060913542 @default.
- W2161036636 cites W2068611497 @default.
- W2161036636 cites W2075665234 @default.
- W2161036636 cites W2076782463 @default.
- W2161036636 cites W2077306952 @default.
- W2161036636 cites W2079496755 @default.
- W2161036636 cites W2087824537 @default.
- W2161036636 cites W2092865108 @default.
- W2161036636 cites W2098107333 @default.
- W2161036636 cites W2106522706 @default.
- W2161036636 cites W2106828113 @default.
- W2161036636 cites W2111062311 @default.
- W2161036636 cites W2120142493 @default.
- W2161036636 cites W2120632482 @default.
- W2161036636 cites W2128134322 @default.
- W2161036636 cites W2128574573 @default.
- W2161036636 cites W2129108032 @default.
- W2161036636 cites W2130784302 @default.
- W2161036636 cites W2132971431 @default.
- W2161036636 cites W2139503851 @default.
- W2161036636 cites W2154390027 @default.
- W2161036636 cites W2161025366 @default.
- W2161036636 cites W2166759337 @default.
- W2161036636 cites W2168319429 @default.
- W2161036636 cites W2169578249 @default.
- W2161036636 cites W2170774618 @default.
- W2161036636 doi "https://doi.org/10.1016/j.neuron.2006.06.013" @default.
- W2161036636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16846856" @default.
- W2161036636 hasPublicationYear "2006" @default.
- W2161036636 type Work @default.
- W2161036636 sameAs 2161036636 @default.
- W2161036636 citedByCount "337" @default.
- W2161036636 countsByYear W21610366362012 @default.
- W2161036636 countsByYear W21610366362013 @default.
- W2161036636 countsByYear W21610366362014 @default.
- W2161036636 countsByYear W21610366362015 @default.
- W2161036636 countsByYear W21610366362016 @default.
- W2161036636 countsByYear W21610366362017 @default.
- W2161036636 countsByYear W21610366362018 @default.
- W2161036636 countsByYear W21610366362019 @default.
- W2161036636 countsByYear W21610366362020 @default.
- W2161036636 countsByYear W21610366362021 @default.
- W2161036636 countsByYear W21610366362022 @default.
- W2161036636 countsByYear W21610366362023 @default.
- W2161036636 crossrefType "journal-article" @default.
- W2161036636 hasAuthorship W2161036636A5019440310 @default.
- W2161036636 hasAuthorship W2161036636A5025530976 @default.
- W2161036636 hasAuthorship W2161036636A5026428336 @default.
- W2161036636 hasAuthorship W2161036636A5052448979 @default.
- W2161036636 hasAuthorship W2161036636A5059441599 @default.
- W2161036636 hasAuthorship W2161036636A5065713713 @default.