FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161078049> ?p ?o ?g. }

• W2161078049 endingPage "CGM.S18581" @default.
• W2161078049 startingPage "CGM.S18581" @default.
• W2161078049 abstract "Caveolae are specialized cell membrane invaginations known to regulate several cancer cell functions and oncogenic signaling pathways. Among other caveolar proteins, they are characterized by the presence of proteins of the cavin family. In this study, we assessed the impact of cavin-1, cavin-2, and cavin-3 on cell migration in a human HT-1080 fibrosarcoma model. We found that all cavin-1, -2 and -3 transcripts were expressed and that treatment with phorbol 12-myristate 13-acetate (PMA), which is known to prime cell migration and proliferation, specifically upregulated cavin-3 gene and protein expression. PMA also triggered matrix metalloproteinase (MMP)-9 secretion, but reduced the global cell migration index. Overexpression of recombinant forms of the three cavins demonstrated that only cavin-3 was able to reduce basal cell migration, and this anti-migratory effect was potentiated by PMA. Interestingly, cavin-3 overexpression inhibited PMA-induced MMP-9, while cavin-3 gene silencing led to an increase in MMP-9 gene expression and secretion. Furthermore, recombinant cavin-3 significantly prevented PMA-mediated dephosphorylation of AKT, a crucial regulator in MMP-9 transcription. In conclusion, our results demonstrate that cellular cavin-3 expression may repress MMP-9 transcriptional regulation in part through AKT. We suggest that the balance in cavin-3-to-MMP-9 expression regulates the extent of extracellular matrix degradation, confirming the tumor-suppressive role of cavin-3 in controlling the invasive potential of human fibrosarcoma cells." @default.
• W2161078049 created "2016-06-24" @default.
• W2161078049 creator A5005866103 @default.
• W2161078049 creator A5007788147 @default.
• W2161078049 creator A5057161946 @default.
• W2161078049 creator A5068140326 @default.
• W2161078049 date "2014-01-01" @default.
• W2161078049 modified "2023-10-02" @default.
• W2161078049 title "A Role for the Cavin-3/Matrix Metalloproteinase-9 Signaling Axis in the Regulation of PMA-Activated Human HT1080 Fibrosarcoma Cell Neoplastic Phenotype" @default.
• W2161078049 cites W136766227 @default.
• W2161078049 cites W1512436727 @default.
• W2161078049 cites W1824182589 @default.
• W2161078049 cites W1963555897 @default.
• W2161078049 cites W1964508300 @default.
• W2161078049 cites W1970361217 @default.
• W2161078049 cites W1979712855 @default.
• W2161078049 cites W1980463804 @default.
• W2161078049 cites W1980529374 @default.
• W2161078049 cites W1985538444 @default.
• W2161078049 cites W1986847123 @default.
• W2161078049 cites W1987611172 @default.
• W2161078049 cites W1993998711 @default.
• W2161078049 cites W1994637704 @default.
• W2161078049 cites W1996405445 @default.
• W2161078049 cites W1996875006 @default.
• W2161078049 cites W1998616440 @default.
• W2161078049 cites W2001107385 @default.
• W2161078049 cites W2002594335 @default.
• W2161078049 cites W2007815675 @default.
• W2161078049 cites W2010513340 @default.
• W2161078049 cites W2012009157 @default.
• W2161078049 cites W2021348596 @default.
• W2161078049 cites W2022228445 @default.
• W2161078049 cites W2030727312 @default.
• W2161078049 cites W2031683256 @default.
• W2161078049 cites W2033529620 @default.
• W2161078049 cites W2034007475 @default.
• W2161078049 cites W2034464608 @default.
• W2161078049 cites W2035920778 @default.
• W2161078049 cites W2038336734 @default.
• W2161078049 cites W2039533054 @default.
• W2161078049 cites W2040196938 @default.
• W2161078049 cites W2044359972 @default.
• W2161078049 cites W2047234875 @default.
• W2161078049 cites W2047818755 @default.
• W2161078049 cites W2049215266 @default.
• W2161078049 cites W2050244697 @default.
• W2161078049 cites W2058562591 @default.
• W2161078049 cites W2065550928 @default.
• W2161078049 cites W2066034304 @default.
• W2161078049 cites W2073259535 @default.
• W2161078049 cites W2077153806 @default.
• W2161078049 cites W2081951738 @default.
• W2161078049 cites W2085154880 @default.
• W2161078049 cites W2088163965 @default.
• W2161078049 cites W2088261391 @default.
• W2161078049 cites W2088667932 @default.
• W2161078049 cites W2100352143 @default.
• W2161078049 cites W2110169410 @default.
• W2161078049 cites W2114844324 @default.
• W2161078049 cites W2118006087 @default.
• W2161078049 cites W2121660570 @default.
• W2161078049 cites W2133837143 @default.
• W2161078049 cites W2141585577 @default.
• W2161078049 cites W2144181069 @default.
• W2161078049 cites W2147537177 @default.
• W2161078049 cites W2161576473 @default.
• W2161078049 cites W2247789152 @default.
• W2161078049 cites W2277636392 @default.
• W2161078049 cites W2300779245 @default.
• W2161078049 doi "https://doi.org/10.4137/cgm.s18581" @default.
• W2161078049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4260767" @default.
• W2161078049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25520561" @default.
• W2161078049 hasPublicationYear "2014" @default.
• W2161078049 type Work @default.
• W2161078049 sameAs 2161078049 @default.
• W2161078049 citedByCount "7" @default.
• W2161078049 countsByYear W21610780492015 @default.
• W2161078049 countsByYear W21610780492016 @default.
• W2161078049 countsByYear W21610780492017 @default.
• W2161078049 countsByYear W21610780492020 @default.
• W2161078049 countsByYear W21610780492021 @default.
• W2161078049 countsByYear W21610780492022 @default.
• W2161078049 crossrefType "journal-article" @default.
• W2161078049 hasAuthorship W2161078049A5005866103 @default.
• W2161078049 hasAuthorship W2161078049A5007788147 @default.
• W2161078049 hasAuthorship W2161078049A5057161946 @default.
• W2161078049 hasAuthorship W2161078049A5068140326 @default.
• W2161078049 hasBestOaLocation W21610780491 @default.
• W2161078049 hasConcept C137738243 @default.
• W2161078049 hasConcept C1491633281 @default.
• W2161078049 hasConcept C185592680 @default.
• W2161078049 hasConcept C2776495794 @default.
• W2161078049 hasConcept C2777751087 @default.
• W2161078049 hasConcept C54355233 @default.
• W2161078049 hasConcept C55493867 @default.
• W2161078049 hasConcept C62478195 @default.
• W2161078049 hasConcept C75217442 @default.

• next