Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161099760> ?p ?o ?g. }
- W2161099760 endingPage "1773" @default.
- W2161099760 startingPage "1765" @default.
- W2161099760 abstract "Studies of gene rearrangements and the consequent oncogenic fusion proteins have laid the foundation for targeted cancer therapy. To identify oncogenic fusions associated with glioma progression, we catalogued fusion transcripts by RNA-seq of 272 gliomas. Fusion transcripts were more frequently found in high-grade gliomas, in the classical subtype of gliomas, and in gliomas treated with radiation/temozolomide. Sixty-seven in-frame fusion transcripts were identified, including three recurrent fusion transcripts: FGFR3-TACC3 , RNF213-SLC26A11 , and PTPRZ1-MET ( ZM ). Interestingly, the ZM fusion was found only in grade III astrocytomas (1/13; 7.7%) or secondary GBMs (sGBMs, 3/20; 15.0%). In an independent cohort of sGBMs, the ZM fusion was found in three of 20 (15%) specimens. Genomic analysis revealed that the fusion arose from translocation events involving introns 3 or 8 of PTPRZ and intron 1 of MET . ZM fusion transcripts were found in GBMs irrespective of isocitrate dehydrogenase 1 ( IDH1 ) mutation status. sGBMs harboring ZM fusion showed higher expression of genes required for PIK3CA signaling and lowered expression of genes that suppressed RB1 or TP53 function. Expression of the ZM fusion was mutually exclusive with EGFR overexpression in sGBMs. Exogenous expression of the ZM fusion in the U87MG glioblastoma line enhanced cell migration and invasion. Clinically, patients afflicted with ZM fusion harboring glioblastomas survived poorly relative to those afflicted with non- ZM -harboring sGBMs ( P < 0.001). Our study profiles the shifting RNA landscape of gliomas during progression and reveled ZM as a novel, recurrent fusion transcript in sGBMs." @default.
- W2161099760 created "2016-06-24" @default.
- W2161099760 creator A5000966388 @default.
- W2161099760 creator A5005526815 @default.
- W2161099760 creator A5005735234 @default.
- W2161099760 creator A5008071965 @default.
- W2161099760 creator A5008391873 @default.
- W2161099760 creator A5019370942 @default.
- W2161099760 creator A5023371427 @default.
- W2161099760 creator A5025392769 @default.
- W2161099760 creator A5028793885 @default.
- W2161099760 creator A5030306351 @default.
- W2161099760 creator A5032363571 @default.
- W2161099760 creator A5039882839 @default.
- W2161099760 creator A5040257921 @default.
- W2161099760 creator A5040730929 @default.
- W2161099760 creator A5046658864 @default.
- W2161099760 creator A5047226301 @default.
- W2161099760 creator A5048245447 @default.
- W2161099760 creator A5051984489 @default.
- W2161099760 creator A5059441813 @default.
- W2161099760 creator A5063611081 @default.
- W2161099760 creator A5065408488 @default.
- W2161099760 creator A5067305959 @default.
- W2161099760 creator A5068252474 @default.
- W2161099760 creator A5074781203 @default.
- W2161099760 creator A5076699095 @default.
- W2161099760 creator A5080092047 @default.
- W2161099760 creator A5082187951 @default.
- W2161099760 date "2014-08-18" @default.
- W2161099760 modified "2023-10-10" @default.
- W2161099760 title "RNA-seq of 272 gliomas revealed a novel, recurrent <i>PTPRZ1-MET</i> fusion transcript in secondary glioblastomas" @default.
- W2161099760 cites W1538419182 @default.
- W2161099760 cites W1592215560 @default.
- W2161099760 cites W1943381782 @default.
- W2161099760 cites W1966803171 @default.
- W2161099760 cites W1967232610 @default.
- W2161099760 cites W1967332632 @default.
- W2161099760 cites W1976295398 @default.
- W2161099760 cites W1984264526 @default.
- W2161099760 cites W1992301683 @default.
- W2161099760 cites W1994581903 @default.
- W2161099760 cites W2000077530 @default.
- W2161099760 cites W2005036868 @default.
- W2161099760 cites W2008721015 @default.
- W2161099760 cites W2012828386 @default.
- W2161099760 cites W2025183726 @default.
- W2161099760 cites W2029623390 @default.
- W2161099760 cites W2036044314 @default.
- W2161099760 cites W2050072146 @default.
- W2161099760 cites W2051571748 @default.
- W2161099760 cites W2055787036 @default.
- W2161099760 cites W2057271193 @default.
- W2161099760 cites W2059971436 @default.
- W2161099760 cites W2071480068 @default.
- W2161099760 cites W2072352009 @default.
- W2161099760 cites W2081938286 @default.
- W2161099760 cites W2086163049 @default.
- W2161099760 cites W2089244852 @default.
- W2161099760 cites W2094903176 @default.
- W2161099760 cites W2096287682 @default.
- W2161099760 cites W2103441770 @default.
- W2161099760 cites W2103894337 @default.
- W2161099760 cites W2107127991 @default.
- W2161099760 cites W2111842868 @default.
- W2161099760 cites W2112592259 @default.
- W2161099760 cites W2125519805 @default.
- W2161099760 cites W2126817554 @default.
- W2161099760 cites W2132308700 @default.
- W2161099760 cites W2139399606 @default.
- W2161099760 cites W2144940507 @default.
- W2161099760 cites W2146516445 @default.
- W2161099760 cites W2151239501 @default.
- W2161099760 cites W2154431984 @default.
- W2161099760 cites W2160382843 @default.
- W2161099760 cites W2161289668 @default.
- W2161099760 cites W2166422007 @default.
- W2161099760 doi "https://doi.org/10.1101/gr.165126.113" @default.
- W2161099760 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4216918" @default.
- W2161099760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25135958" @default.
- W2161099760 hasPublicationYear "2014" @default.
- W2161099760 type Work @default.
- W2161099760 sameAs 2161099760 @default.
- W2161099760 citedByCount "293" @default.
- W2161099760 countsByYear W21610997602014 @default.
- W2161099760 countsByYear W21610997602015 @default.
- W2161099760 countsByYear W21610997602016 @default.
- W2161099760 countsByYear W21610997602017 @default.
- W2161099760 countsByYear W21610997602018 @default.
- W2161099760 countsByYear W21610997602019 @default.
- W2161099760 countsByYear W21610997602020 @default.
- W2161099760 countsByYear W21610997602021 @default.
- W2161099760 countsByYear W21610997602022 @default.
- W2161099760 countsByYear W21610997602023 @default.
- W2161099760 crossrefType "journal-article" @default.
- W2161099760 hasAuthorship W2161099760A5000966388 @default.
- W2161099760 hasAuthorship W2161099760A5005526815 @default.
- W2161099760 hasAuthorship W2161099760A5005735234 @default.