FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161103103> ?p ?o ?g. }

• W2161103103 endingPage "170" @default.
• W2161103103 startingPage "166" @default.
• W2161103103 abstract "Prostate cancer is an increasingly common disease for which there are few well-established risk factors. Family history data suggest a genetic component; however, the majority of prostate cancer cases cannot be explained by a single-gene model. Prostate cell division is influenced by two steroid hormones, testosterone and vitamin D, the action of each being mediated by its respective receptor. The genes for the two receptors are candidates in a multigenic model for prostate cancer susceptibility.We examined genetic polymorphisms in two steroid receptors, the androgen receptor (AR) and the vitamin D receptor (VDR), in a case-control pilot study of prostate cancer.Fifty-seven non-Hispanic white case patients with prostate cancer and 169 non-Hispanic white control subjects were genotyped for a previously described microsatellite (CAG repeats) in the AR gene and for a newly discovered poly-A microsatellite in the 3'-untranslated region (3'UTR) of the VDR gene. To compare genotypes with respect to prostate cancer risk, we estimated odds ratios (ORs) by using logistic regression. ORs were also estimated separately for advanced and localized cases of disease. All P values resulted from two-sided tests.Both the AR and the VDR polymorphisms were associated, individually and after mutual adjustment, with prostate cancer. Adjusted ORs (95% confidence intervals [CIs]) for prostate cancer were 2.10 (95% CI = 1.11-3.99) for individuals carrying an AR CAG allele with fewer than 20 repeats versus an allele with 20 or more repeats and 4.61 (95% CI = 1.34-15.82) for individuals carrying at least one long (A18 to A22) VDR poly-A allele versus two short (A14 to A17) poly-A alleles. For both the AR and VDR genes, the at-risk genotypes were more strongly associated with advanced disease than with localized disease.In this pilot study, genetic variation in both the VDR and the AR genes was associated with prostate cancer, and both genes appear to preferentially confer risk for advanced disease. These two genetic risk factors, if confirmed, are among the strongest risk factors yet identified for prostate cancer.These results are consistent with a multigenic model of prostate cancer susceptibility. On the basis of the joint effect of several genetic loci, one might ultimately be able to construct a risk profile to predict advanced disease, so that men whose disease is unlikely to progress to an advanced stage can possibly be spared aggressive treatment." @default.
• W2161103103 created "2016-06-24" @default.
• W2161103103 creator A5014329282 @default.
• W2161103103 creator A5026527537 @default.
• W2161103103 creator A5038379283 @default.
• W2161103103 creator A5039683062 @default.
• W2161103103 creator A5046773247 @default.
• W2161103103 creator A5070309168 @default.
• W2161103103 creator A5074503361 @default.
• W2161103103 date "1997-01-15" @default.
• W2161103103 modified "2023-10-16" @default.
• W2161103103 title "Association of Prostate Cancer Risk With Genetic Polymorphisms in Vitamin D Receptor and Androgen Receptor" @default.
• W2161103103 cites W106733404 @default.
• W2161103103 cites W1974417396 @default.
• W2161103103 cites W1976706733 @default.
• W2161103103 cites W1994778192 @default.
• W2161103103 cites W1998476721 @default.
• W2161103103 cites W2000731870 @default.
• W2161103103 cites W2009180025 @default.
• W2161103103 cites W2028896946 @default.
• W2161103103 cites W2053670125 @default.
• W2161103103 cites W2055066655 @default.
• W2161103103 cites W2067027353 @default.
• W2161103103 cites W2070718488 @default.
• W2161103103 cites W2076971451 @default.
• W2161103103 cites W2084779586 @default.
• W2161103103 cites W2089514388 @default.
• W2161103103 cites W2094631104 @default.
• W2161103103 cites W2113333419 @default.
• W2161103103 cites W2162741492 @default.
• W2161103103 cites W4254967846 @default.
• W2161103103 doi "https://doi.org/10.1093/jnci/89.2.166" @default.
• W2161103103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8998186" @default.
• W2161103103 hasPublicationYear "1997" @default.
• W2161103103 type Work @default.
• W2161103103 sameAs 2161103103 @default.
• W2161103103 citedByCount "560" @default.
• W2161103103 countsByYear W21611031032012 @default.
• W2161103103 countsByYear W21611031032013 @default.
• W2161103103 countsByYear W21611031032014 @default.
• W2161103103 countsByYear W21611031032015 @default.
• W2161103103 countsByYear W21611031032016 @default.
• W2161103103 countsByYear W21611031032017 @default.
• W2161103103 countsByYear W21611031032018 @default.
• W2161103103 countsByYear W21611031032019 @default.
• W2161103103 countsByYear W21611031032020 @default.
• W2161103103 countsByYear W21611031032021 @default.
• W2161103103 countsByYear W21611031032022 @default.
• W2161103103 countsByYear W21611031032023 @default.
• W2161103103 crossrefType "journal-article" @default.
• W2161103103 hasAuthorship W2161103103A5014329282 @default.
• W2161103103 hasAuthorship W2161103103A5026527537 @default.
• W2161103103 hasAuthorship W2161103103A5038379283 @default.
• W2161103103 hasAuthorship W2161103103A5039683062 @default.
• W2161103103 hasAuthorship W2161103103A5046773247 @default.
• W2161103103 hasAuthorship W2161103103A5070309168 @default.
• W2161103103 hasAuthorship W2161103103A5074503361 @default.
• W2161103103 hasBestOaLocation W21611031031 @default.
• W2161103103 hasConcept C104317684 @default.
• W2161103103 hasConcept C121608353 @default.
• W2161103103 hasConcept C124490489 @default.
• W2161103103 hasConcept C126322002 @default.
• W2161103103 hasConcept C134018914 @default.
• W2161103103 hasConcept C135763542 @default.
• W2161103103 hasConcept C143998085 @default.
• W2161103103 hasConcept C156957248 @default.
• W2161103103 hasConcept C179639408 @default.
• W2161103103 hasConcept C180754005 @default.
• W2161103103 hasConcept C2776235491 @default.
• W2161103103 hasConcept C2779279991 @default.
• W2161103103 hasConcept C2780192828 @default.
• W2161103103 hasConcept C54355233 @default.
• W2161103103 hasConcept C61367390 @default.
• W2161103103 hasConcept C71924100 @default.
• W2161103103 hasConcept C86803240 @default.
• W2161103103 hasConceptScore W2161103103C104317684 @default.
• W2161103103 hasConceptScore W2161103103C121608353 @default.
• W2161103103 hasConceptScore W2161103103C124490489 @default.
• W2161103103 hasConceptScore W2161103103C126322002 @default.
• W2161103103 hasConceptScore W2161103103C134018914 @default.
• W2161103103 hasConceptScore W2161103103C135763542 @default.
• W2161103103 hasConceptScore W2161103103C143998085 @default.
• W2161103103 hasConceptScore W2161103103C156957248 @default.
• W2161103103 hasConceptScore W2161103103C179639408 @default.
• W2161103103 hasConceptScore W2161103103C180754005 @default.
• W2161103103 hasConceptScore W2161103103C2776235491 @default.
• W2161103103 hasConceptScore W2161103103C2779279991 @default.
• W2161103103 hasConceptScore W2161103103C2780192828 @default.
• W2161103103 hasConceptScore W2161103103C54355233 @default.
• W2161103103 hasConceptScore W2161103103C61367390 @default.
• W2161103103 hasConceptScore W2161103103C71924100 @default.
• W2161103103 hasConceptScore W2161103103C86803240 @default.
• W2161103103 hasIssue "2" @default.
• W2161103103 hasLocation W21611031031 @default.
• W2161103103 hasLocation W21611031032 @default.
• W2161103103 hasOpenAccess W2161103103 @default.
• W2161103103 hasPrimaryLocation W21611031031 @default.
• W2161103103 hasRelatedWork W1998113603 @default.

• next