Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161129080> ?p ?o ?g. }
- W2161129080 endingPage "444" @default.
- W2161129080 startingPage "433" @default.
- W2161129080 abstract "Interleukin-18 (IL-18) plays pivotal roles in linking inflammatory immune responses and tumor progression and metastasis, yet the manner in which this occurs remains to be sufficiently clarified. Here we report that hypoxia induces the transcription and secretion of IL-18, which subsequently induces the expression of hypoxia-inducible factor-1α (HIF-1α). Mechanistically, IL-18 induces HIF-1α through the activity of the GTPase Rac1, which inducibly associates with the IL-18 receptor β (IL-18Rβ) subunit, via a PI3K-AKT-NF-κB–dependent pathway. Importantly, the knockdown of the IL-18Rβ subunit inhibited IL-18–driven tumor cell metastasis. Collectively, these findings demonstrate a feed-forward pathway in HIF-1α–mediated tumor progression, in which the induction of IL-18 by hypoxia or inflammatory cells augments the expression of both HIF-1α and tumor cell metastasis." @default.
- W2161129080 created "2016-06-24" @default.
- W2161129080 creator A5002593213 @default.
- W2161129080 creator A5012262617 @default.
- W2161129080 creator A5012791367 @default.
- W2161129080 creator A5021758819 @default.
- W2161129080 creator A5046181932 @default.
- W2161129080 creator A5050054431 @default.
- W2161129080 creator A5062359726 @default.
- W2161129080 creator A5067736162 @default.
- W2161129080 creator A5067756034 @default.
- W2161129080 creator A5078898813 @default.
- W2161129080 creator A5090140728 @default.
- W2161129080 date "2008-02-01" @default.
- W2161129080 modified "2023-10-17" @default.
- W2161129080 title "Hypoxia-induced IL-18 Increases Hypoxia-inducible Factor-1α Expression through a Rac1-dependent NF-κB Pathway" @default.
- W2161129080 cites W1493048246 @default.
- W2161129080 cites W1513905735 @default.
- W2161129080 cites W1529375690 @default.
- W2161129080 cites W1565071972 @default.
- W2161129080 cites W1968044382 @default.
- W2161129080 cites W1970523400 @default.
- W2161129080 cites W1973092951 @default.
- W2161129080 cites W1973720695 @default.
- W2161129080 cites W1974093434 @default.
- W2161129080 cites W1993808418 @default.
- W2161129080 cites W2000204354 @default.
- W2161129080 cites W2000272522 @default.
- W2161129080 cites W2020823643 @default.
- W2161129080 cites W2044899507 @default.
- W2161129080 cites W2046601184 @default.
- W2161129080 cites W2051611091 @default.
- W2161129080 cites W2052895824 @default.
- W2161129080 cites W2063553928 @default.
- W2161129080 cites W2069207808 @default.
- W2161129080 cites W2069996037 @default.
- W2161129080 cites W2081293223 @default.
- W2161129080 cites W2082483448 @default.
- W2161129080 cites W2088159030 @default.
- W2161129080 cites W2091917736 @default.
- W2161129080 cites W2100701027 @default.
- W2161129080 cites W2107277218 @default.
- W2161129080 cites W2107604105 @default.
- W2161129080 cites W2144707486 @default.
- W2161129080 cites W2160076389 @default.
- W2161129080 cites W2160100702 @default.
- W2161129080 cites W2160821900 @default.
- W2161129080 cites W2164492572 @default.
- W2161129080 cites W2165523086 @default.
- W2161129080 cites W2169367420 @default.
- W2161129080 cites W2171065062 @default.
- W2161129080 doi "https://doi.org/10.1091/mbc.e07-02-0182" @default.
- W2161129080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2230593" @default.
- W2161129080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18003981" @default.
- W2161129080 hasPublicationYear "2008" @default.
- W2161129080 type Work @default.
- W2161129080 sameAs 2161129080 @default.
- W2161129080 citedByCount "48" @default.
- W2161129080 countsByYear W21611290802012 @default.
- W2161129080 countsByYear W21611290802013 @default.
- W2161129080 countsByYear W21611290802014 @default.
- W2161129080 countsByYear W21611290802015 @default.
- W2161129080 countsByYear W21611290802016 @default.
- W2161129080 countsByYear W21611290802017 @default.
- W2161129080 countsByYear W21611290802018 @default.
- W2161129080 countsByYear W21611290802019 @default.
- W2161129080 countsByYear W21611290802020 @default.
- W2161129080 countsByYear W21611290802021 @default.
- W2161129080 countsByYear W21611290802022 @default.
- W2161129080 countsByYear W21611290802023 @default.
- W2161129080 crossrefType "journal-article" @default.
- W2161129080 hasAuthorship W2161129080A5002593213 @default.
- W2161129080 hasAuthorship W2161129080A5012262617 @default.
- W2161129080 hasAuthorship W2161129080A5012791367 @default.
- W2161129080 hasAuthorship W2161129080A5021758819 @default.
- W2161129080 hasAuthorship W2161129080A5046181932 @default.
- W2161129080 hasAuthorship W2161129080A5050054431 @default.
- W2161129080 hasAuthorship W2161129080A5062359726 @default.
- W2161129080 hasAuthorship W2161129080A5067736162 @default.
- W2161129080 hasAuthorship W2161129080A5067756034 @default.
- W2161129080 hasAuthorship W2161129080A5078898813 @default.
- W2161129080 hasAuthorship W2161129080A5090140728 @default.
- W2161129080 hasBestOaLocation W21611290802 @default.
- W2161129080 hasConcept C104292427 @default.
- W2161129080 hasConcept C104317684 @default.
- W2161129080 hasConcept C160450060 @default.
- W2161129080 hasConcept C173396325 @default.
- W2161129080 hasConcept C178790620 @default.
- W2161129080 hasConcept C185592680 @default.
- W2161129080 hasConcept C203014093 @default.
- W2161129080 hasConcept C2779256057 @default.
- W2161129080 hasConcept C2779717556 @default.
- W2161129080 hasConcept C502942594 @default.
- W2161129080 hasConcept C540031477 @default.
- W2161129080 hasConcept C54355233 @default.
- W2161129080 hasConcept C55493867 @default.
- W2161129080 hasConcept C62478195 @default.
- W2161129080 hasConcept C75217442 @default.