FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161133478> ?p ?o ?g. }

• W2161133478 endingPage "7652" @default.
• W2161133478 startingPage "7647" @default.
• W2161133478 abstract "Abstract We report here a modified auxotrophic strain of Salmonella typhimurium that can target and cure breast tumors in orthotopic mouse models. We have previously reported development of a genetically modified strain of S. typhimurium, selected for prostate tumor targeting and therapy in vivo. The strain, termed S. typhimurium A1, selectively grew in prostate tumors in xenograft models causing tumor regression. In contrast, normal tissue was cleared of these bacteria even in immunodeficient athymic mice with no apparent side effects. A1 is auxotrophic (leucine-arginine dependent) but apparently receives sufficient nutritional support only from tumor tissue. The ability to grow in viable tumor tissue may account, in part, for the unique antitumor efficacy of the strain. In the present report, to increase tumor-targeting capability of A1, the strain was reisolated after infection of a human colon tumor growing in nude mice. The tumor-isolated strain, termed A1-R, had increased targeting for tumor cells in vivo as well as in vitro compared with A1. Treatment with A1-R resulted in highly effective tumor targeting, including viable tumor tissue and significant tumor shrinkage in mice with s.c. or orthotopic human breast cancer xerographs. Survival of the treated animals was significantly prolonged. Forty percent of treated mice were cured completely and survived as long as non–tumor-bearing mice. These results suggest that amino acid auxotrophic virulent bacteria, which selectively infect and attack viable tumor tissue, are a promising approach to cancer therapy. (Cancer Res 2006; 66(15): 7647-52)" @default.
• W2161133478 created "2016-06-24" @default.
• W2161133478 creator A5018359120 @default.
• W2161133478 creator A5023556030 @default.
• W2161133478 creator A5040819666 @default.
• W2161133478 creator A5057141414 @default.
• W2161133478 creator A5076304376 @default.
• W2161133478 creator A5083408391 @default.
• W2161133478 creator A5083743508 @default.
• W2161133478 creator A5084461414 @default.
• W2161133478 date "2006-08-01" @default.
• W2161133478 modified "2023-10-11" @default.
• W2161133478 title "Targeted Therapy with a<i>Salmonella Typhimurium</i>Leucine-Arginine Auxotroph Cures Orthotopic Human Breast Tumors in Nude Mice" @default.
• W2161133478 cites W1518520618 @default.
• W2161133478 cites W1595241211 @default.
• W2161133478 cites W1975899736 @default.
• W2161133478 cites W2014073110 @default.
• W2161133478 cites W2028567355 @default.
• W2161133478 cites W2039383456 @default.
• W2161133478 cites W2042048278 @default.
• W2161133478 cites W2046894146 @default.
• W2161133478 cites W2073447587 @default.
• W2161133478 cites W2078576368 @default.
• W2161133478 cites W2082013458 @default.
• W2161133478 cites W2089170255 @default.
• W2161133478 cites W2096016418 @default.
• W2161133478 cites W2106953557 @default.
• W2161133478 cites W2115205513 @default.
• W2161133478 cites W2122971790 @default.
• W2161133478 cites W2136246490 @default.
• W2161133478 cites W4242852378 @default.
• W2161133478 doi "https://doi.org/10.1158/0008-5472.can-06-0716" @default.
• W2161133478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16885365" @default.
• W2161133478 hasPublicationYear "2006" @default.
• W2161133478 type Work @default.
• W2161133478 sameAs 2161133478 @default.
• W2161133478 citedByCount "266" @default.
• W2161133478 countsByYear W21611334782012 @default.
• W2161133478 countsByYear W21611334782013 @default.
• W2161133478 countsByYear W21611334782014 @default.
• W2161133478 countsByYear W21611334782015 @default.
• W2161133478 countsByYear W21611334782016 @default.
• W2161133478 countsByYear W21611334782017 @default.
• W2161133478 countsByYear W21611334782018 @default.
• W2161133478 countsByYear W21611334782019 @default.
• W2161133478 countsByYear W21611334782020 @default.
• W2161133478 countsByYear W21611334782021 @default.
• W2161133478 countsByYear W21611334782022 @default.
• W2161133478 countsByYear W21611334782023 @default.
• W2161133478 crossrefType "journal-article" @default.
• W2161133478 hasAuthorship W2161133478A5018359120 @default.
• W2161133478 hasAuthorship W2161133478A5023556030 @default.
• W2161133478 hasAuthorship W2161133478A5040819666 @default.
• W2161133478 hasAuthorship W2161133478A5057141414 @default.
• W2161133478 hasAuthorship W2161133478A5076304376 @default.
• W2161133478 hasAuthorship W2161133478A5083408391 @default.
• W2161133478 hasAuthorship W2161133478A5083743508 @default.
• W2161133478 hasAuthorship W2161133478A5084461414 @default.
• W2161133478 hasBestOaLocation W21611334781 @default.
• W2161133478 hasConcept C104317684 @default.
• W2161133478 hasConcept C121608353 @default.
• W2161133478 hasConcept C126322002 @default.
• W2161133478 hasConcept C150903083 @default.
• W2161133478 hasConcept C202751555 @default.
• W2161133478 hasConcept C207001950 @default.
• W2161133478 hasConcept C20950039 @default.
• W2161133478 hasConcept C2776235491 @default.
• W2161133478 hasConcept C2777468819 @default.
• W2161133478 hasConcept C2780192828 @default.
• W2161133478 hasConcept C2781065037 @default.
• W2161133478 hasConcept C502942594 @default.
• W2161133478 hasConcept C515207424 @default.
• W2161133478 hasConcept C523546767 @default.
• W2161133478 hasConcept C530470458 @default.
• W2161133478 hasConcept C54355233 @default.
• W2161133478 hasConcept C547475151 @default.
• W2161133478 hasConcept C55493867 @default.
• W2161133478 hasConcept C71924100 @default.
• W2161133478 hasConcept C86803240 @default.
• W2161133478 hasConceptScore W2161133478C104317684 @default.
• W2161133478 hasConceptScore W2161133478C121608353 @default.
• W2161133478 hasConceptScore W2161133478C126322002 @default.
• W2161133478 hasConceptScore W2161133478C150903083 @default.
• W2161133478 hasConceptScore W2161133478C202751555 @default.
• W2161133478 hasConceptScore W2161133478C207001950 @default.
• W2161133478 hasConceptScore W2161133478C20950039 @default.
• W2161133478 hasConceptScore W2161133478C2776235491 @default.
• W2161133478 hasConceptScore W2161133478C2777468819 @default.
• W2161133478 hasConceptScore W2161133478C2780192828 @default.
• W2161133478 hasConceptScore W2161133478C2781065037 @default.
• W2161133478 hasConceptScore W2161133478C502942594 @default.
• W2161133478 hasConceptScore W2161133478C515207424 @default.
• W2161133478 hasConceptScore W2161133478C523546767 @default.
• W2161133478 hasConceptScore W2161133478C530470458 @default.
• W2161133478 hasConceptScore W2161133478C54355233 @default.
• W2161133478 hasConceptScore W2161133478C547475151 @default.
• W2161133478 hasConceptScore W2161133478C55493867 @default.
• W2161133478 hasConceptScore W2161133478C71924100 @default.

• next