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- W2161135617 abstract "Pdx1 (IPF-1 in humans, which is altered in MODY-4) is essential for pancreas development and mature beta-cell function. Pdx1 is expressed dynamically within the developing foregut, but how its expression characteristics are linked to the various steps of organ specification, differentiation, and function is unknown. Deletion of a conserved enhancer region (Area I-II-III) from Pdx1 produced a hypomorphic allele (Pdx1(DeltaI-II-III)) with altered timing and level of expression, which was studied in combination with wild-type and protein-null alleles. Lineage labeling in homozygous Area I-II-III deletion mutants (Pdx1(DeltaI-II-III/DeltaI-II-III)) revealed lack of ventral pancreatic bud specification and early-onset hypoplasia in the dorsal bud. Acinar tissue formed in the hypoplastic dorsal bud, but endocrine maturation was greatly impaired. While Pdx1(-/-) (protein-null) mice have nonpancreatic abnormalities (e.g., distorted pylorus, absent Brunner's glands), these structures formed normally in Pdx1(DeltaI-II-III/DeltaI-II-III) and Pdx1(DeltaI-II-III/-) mice. Surprisingly, heterozygous (Pdx1(+/DeltaI-II-III)) mice had abnormal islets and a more severe prediabetic condition than Pdx1(+/-) mice. These findings provide in vivo evidence of the differential requirements for the level of Pdx1 gene activity in the specification and differentiation of the various organs of the posterior foregut, as well as in pancreas and gut endocrine cell differentiation." @default.
- W2161135617 created "2016-06-24" @default.
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- W2161135617 date "2006-01-15" @default.
- W2161135617 modified "2023-10-15" @default.
- W2161135617 title "Targeted deletion of a <i>cis</i>-regulatory region reveals differential gene dosage requirements for <i>Pdx1</i> in foregut organ differentiation and pancreas formation" @default.
- W2161135617 cites W153919731 @default.
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- W2161135617 cites W1573536022 @default.
- W2161135617 cites W1593837562 @default.
- W2161135617 cites W1627567497 @default.
- W2161135617 cites W1830287761 @default.
- W2161135617 cites W1844743435 @default.
- W2161135617 cites W1961434948 @default.
- W2161135617 cites W1974369751 @default.
- W2161135617 cites W1979445839 @default.
- W2161135617 cites W1992517228 @default.
- W2161135617 cites W1993055783 @default.
- W2161135617 cites W1995532669 @default.
- W2161135617 cites W2000402766 @default.
- W2161135617 cites W2000511325 @default.
- W2161135617 cites W2003207229 @default.
- W2161135617 cites W2003535661 @default.
- W2161135617 cites W2005688198 @default.
- W2161135617 cites W2017911450 @default.
- W2161135617 cites W2023590823 @default.
- W2161135617 cites W2025397278 @default.
- W2161135617 cites W2026145411 @default.
- W2161135617 cites W2033045615 @default.
- W2161135617 cites W2035843625 @default.
- W2161135617 cites W2037028566 @default.
- W2161135617 cites W2038136784 @default.
- W2161135617 cites W2045467715 @default.
- W2161135617 cites W2046097974 @default.
- W2161135617 cites W2048056915 @default.
- W2161135617 cites W2050395079 @default.
- W2161135617 cites W2050610306 @default.
- W2161135617 cites W2058125858 @default.
- W2161135617 cites W2061057966 @default.
- W2161135617 cites W2066135299 @default.
- W2161135617 cites W2066275743 @default.
- W2161135617 cites W2070884732 @default.
- W2161135617 cites W2078561941 @default.
- W2161135617 cites W2082255237 @default.
- W2161135617 cites W2084707443 @default.
- W2161135617 cites W2101879407 @default.
- W2161135617 cites W2110320405 @default.
- W2161135617 cites W2113216468 @default.
- W2161135617 cites W2124241844 @default.
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- W2161135617 cites W2142486892 @default.
- W2161135617 cites W2142986021 @default.
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- W2161135617 cites W2148078342 @default.
- W2161135617 cites W2149423178 @default.
- W2161135617 cites W2157223171 @default.
- W2161135617 cites W2159369466 @default.
- W2161135617 cites W2166421062 @default.
- W2161135617 cites W2168593494 @default.
- W2161135617 cites W2169745228 @default.
- W2161135617 cites W2346386977 @default.
- W2161135617 cites W2410727882 @default.
- W2161135617 cites W2413629840 @default.
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- W2161135617 doi "https://doi.org/10.1101/gad.1360106" @default.
- W2161135617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1356115" @default.
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- W2161135617 hasPublicationYear "2006" @default.
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