FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161151504> ?p ?o ?g. }

• W2161151504 endingPage "2964" @default.
• W2161151504 startingPage "2954" @default.
• W2161151504 abstract "Strategies to induce potent and broad antibody responses against the human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Env) at both systemic and mucosal sites represent a central goal for HIV-1 vaccine development. Here, we show that the non-toxic CTA1-DD adjuvant promoted mucosal and systemic humoral and cell-mediated immune responses following intranasal (i.n.) immunizations with trimeric or monomeric forms of HIV-1 Env in mice and in non-human primates. Env-specific IgG subclasses in the serum of immunized mice reflected a balanced Th1/Th2 type of response. Strikingly, i.n. immunizations with Env and the CTA1-DD adjuvant induced substantial levels of mucosal anti-Env IgA in bronchial alveolar lavage and also detectable levels in vaginal secretions. By contrast, parenteral immunizations of Env formulated in Ribi did not stimulate mucosal IgA responses, while the two adjuvants induced a similar distribution of Env-specific IgG-subclasses in serum. A single parenteral boost with Env in Ribi adjuvant into mice previously primed i.n. with Env and CTA1-DD, augmented the serum anti-Env IgG levels to similar magnitudes as those observed after three intraperitoneal immunizations with Env in Ribi. The augmenting potency of CTA1-DD was similar to that of LTK63 or CpG oligodeoxynucleotides (ODN). However, in contrast to CpG ODN, the effect of CTA1-DD and LTK63 appeared to be independent of MyD88 and toll-like receptor signalling. This is the first demonstration that CTA1-DD augments specific immune responses also in non-human primates, suggesting that this adjuvant could be explored further as a clinically safe mucosal vaccine adjuvant for humoral and cell-mediated immunity against HIV-1 Env." @default.
• W2161151504 created "2016-06-24" @default.
• W2161151504 creator A5022155820 @default.
• W2161151504 creator A5024029113 @default.
• W2161151504 creator A5037023603 @default.
• W2161151504 creator A5037123473 @default.
• W2161151504 creator A5057883319 @default.
• W2161151504 creator A5058665704 @default.
• W2161151504 creator A5083386185 @default.
• W2161151504 creator A5091062006 @default.
• W2161151504 date "2008-12-01" @default.
• W2161151504 modified "2023-10-01" @default.
• W2161151504 title "CTA1-DD adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization" @default.
• W2161151504 cites W1482903412 @default.
• W2161151504 cites W1484937345 @default.
• W2161151504 cites W1710348905 @default.
• W2161151504 cites W1828188056 @default.
• W2161151504 cites W1861867405 @default.
• W2161151504 cites W1891734594 @default.
• W2161151504 cites W1896912566 @default.
• W2161151504 cites W1967050458 @default.
• W2161151504 cites W1968360645 @default.
• W2161151504 cites W1972130319 @default.
• W2161151504 cites W1972261522 @default.
• W2161151504 cites W1973581581 @default.
• W2161151504 cites W1975109518 @default.
• W2161151504 cites W1985875267 @default.
• W2161151504 cites W1986103819 @default.
• W2161151504 cites W1992317534 @default.
• W2161151504 cites W1994609426 @default.
• W2161151504 cites W1998987175 @default.
• W2161151504 cites W2001192978 @default.
• W2161151504 cites W2001559562 @default.
• W2161151504 cites W2001953488 @default.
• W2161151504 cites W2001988677 @default.
• W2161151504 cites W2002392006 @default.
• W2161151504 cites W2003344929 @default.
• W2161151504 cites W2012852949 @default.
• W2161151504 cites W2013103459 @default.
• W2161151504 cites W2014805409 @default.
• W2161151504 cites W2028682232 @default.
• W2161151504 cites W2031517424 @default.
• W2161151504 cites W2036306713 @default.
• W2161151504 cites W2036851405 @default.
• W2161151504 cites W2040749046 @default.
• W2161151504 cites W2042582498 @default.
• W2161151504 cites W2043409853 @default.
• W2161151504 cites W2045446870 @default.
• W2161151504 cites W2058632331 @default.
• W2161151504 cites W2062696541 @default.
• W2161151504 cites W2065329551 @default.
• W2161151504 cites W2067107443 @default.
• W2161151504 cites W2070597700 @default.
• W2161151504 cites W2070701468 @default.
• W2161151504 cites W2074179097 @default.
• W2161151504 cites W2074620757 @default.
• W2161151504 cites W2076801829 @default.
• W2161151504 cites W2083407483 @default.
• W2161151504 cites W2085114777 @default.
• W2161151504 cites W2085536043 @default.
• W2161151504 cites W2085662163 @default.
• W2161151504 cites W2088341214 @default.
• W2161151504 cites W2100421927 @default.
• W2161151504 cites W2103038524 @default.
• W2161151504 cites W2105841559 @default.
• W2161151504 cites W2112688771 @default.
• W2161151504 cites W2113140974 @default.
• W2161151504 cites W2119671142 @default.
• W2161151504 cites W2124859691 @default.
• W2161151504 cites W2129274180 @default.
• W2161151504 cites W2140927222 @default.
• W2161151504 cites W2144023036 @default.
• W2161151504 cites W2152640863 @default.
• W2161151504 cites W2154076028 @default.
• W2161151504 cites W2155391532 @default.
• W2161151504 cites W2157585612 @default.
• W2161151504 cites W2158614517 @default.
• W2161151504 cites W2160056486 @default.
• W2161151504 cites W2161426250 @default.
• W2161151504 cites W2165804767 @default.
• W2161151504 cites W2169383056 @default.
• W2161151504 cites W4231319817 @default.
• W2161151504 cites W4313309844 @default.
• W2161151504 cites W4313331912 @default.
• W2161151504 cites W4375905922 @default.
• W2161151504 doi "https://doi.org/10.1099/vir.0.2008/005470-0" @default.
• W2161151504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19008380" @default.
• W2161151504 hasPublicationYear "2008" @default.
• W2161151504 type Work @default.
• W2161151504 sameAs 2161151504 @default.
• W2161151504 citedByCount "44" @default.
• W2161151504 countsByYear W21611515042012 @default.
• W2161151504 countsByYear W21611515042013 @default.
• W2161151504 countsByYear W21611515042014 @default.
• W2161151504 countsByYear W21611515042015 @default.
• W2161151504 countsByYear W21611515042016 @default.
• W2161151504 countsByYear W21611515042018 @default.
• W2161151504 countsByYear W21611515042019 @default.

• next