Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161182903> ?p ?o ?g. }
- W2161182903 endingPage "239" @default.
- W2161182903 startingPage "239" @default.
- W2161182903 abstract "In order to investigate the implication of viral replication in acute, subacute, and chronic infections of coxsackievirus B3 (CVB3), we examined the histopathological changes and plus- and minus-strand viral RNA dynamics in heart, pancreas, brain, and liver of CVB3-infected A/J mice. Mice were inoculated intraperitoneally with CVB3 and sacrificed on 1, 2, 3, 4, 7, 10, 14, 21, 30, 60, and 90 days post infection (p.i.). Plus- and minus-strand viral RNAs in the organs were quantitated and the organs were additionally evaluated histopathologically for inflammation. No inflammatory infiltrates were observed in the liver, brain, and heart. In contrast, massive lymphocyte infiltration and fat replacement were shown in the pancreas with loss of acinar cells. Both plus- and minus-strand viral RNA levels were detected by 21 days p.i. in heart, 90 days p.i. in pancreas, 4 days p.i. in liver, and 10 days p.i. in brain. The plus-strand RNA was found at least fifty fold higher than the minus-strand RNA by 4 days p.i. in heart and pancreas and by 3 days p.i. in liver. The plus- to minus-strand RNA ratio in brain was found less than 1:20. Our data indicate that viral replication was actively occurred in heart, pancreas, and liver during acute CVB3 infection, whereas viral replication was limited in brain. Furthermore, chronic persistent viral RNA was observed in pancreas. In conclusion, CVB3 at low dose of virus induces severe pancreatitis but marginal or no inflammatory changes in the heart, liver, and brain." @default.
- W2161182903 created "2016-06-24" @default.
- W2161182903 creator A5003819949 @default.
- W2161182903 creator A5013878745 @default.
- W2161182903 creator A5036438869 @default.
- W2161182903 creator A5037944162 @default.
- W2161182903 creator A5059140020 @default.
- W2161182903 creator A5077643083 @default.
- W2161182903 date "2008-01-01" @default.
- W2161182903 modified "2023-10-02" @default.
- W2161182903 title "Expression of Plus- and Minus-strand Viral RNA in Coxsackievirus B3-Infected A/J Mice" @default.
- W2161182903 cites W1510540477 @default.
- W2161182903 cites W1595782547 @default.
- W2161182903 cites W1622415113 @default.
- W2161182903 cites W1981970027 @default.
- W2161182903 cites W1993537053 @default.
- W2161182903 cites W2003594429 @default.
- W2161182903 cites W2041037252 @default.
- W2161182903 cites W2043151970 @default.
- W2161182903 cites W2053925606 @default.
- W2161182903 cites W2055348799 @default.
- W2161182903 cites W2055887339 @default.
- W2161182903 cites W2058037868 @default.
- W2161182903 cites W2058383671 @default.
- W2161182903 cites W2072063083 @default.
- W2161182903 cites W2077411286 @default.
- W2161182903 cites W2088350742 @default.
- W2161182903 cites W2089661843 @default.
- W2161182903 cites W2094195780 @default.
- W2161182903 cites W2108847184 @default.
- W2161182903 cites W2113014254 @default.
- W2161182903 cites W2114712696 @default.
- W2161182903 cites W2119746925 @default.
- W2161182903 cites W2127953586 @default.
- W2161182903 cites W2134909717 @default.
- W2161182903 cites W2150997852 @default.
- W2161182903 cites W2157458496 @default.
- W2161182903 cites W2167906966 @default.
- W2161182903 cites W2169798680 @default.
- W2161182903 cites W574546459 @default.
- W2161182903 doi "https://doi.org/10.4167/jbv.2008.38.4.239" @default.
- W2161182903 hasPublicationYear "2008" @default.
- W2161182903 type Work @default.
- W2161182903 sameAs 2161182903 @default.
- W2161182903 citedByCount "0" @default.
- W2161182903 crossrefType "journal-article" @default.
- W2161182903 hasAuthorship W2161182903A5003819949 @default.
- W2161182903 hasAuthorship W2161182903A5013878745 @default.
- W2161182903 hasAuthorship W2161182903A5036438869 @default.
- W2161182903 hasAuthorship W2161182903A5037944162 @default.
- W2161182903 hasAuthorship W2161182903A5059140020 @default.
- W2161182903 hasAuthorship W2161182903A5077643083 @default.
- W2161182903 hasBestOaLocation W21611829031 @default.
- W2161182903 hasConcept C104317684 @default.
- W2161182903 hasConcept C126322002 @default.
- W2161182903 hasConcept C134018914 @default.
- W2161182903 hasConcept C140704245 @default.
- W2161182903 hasConcept C142724271 @default.
- W2161182903 hasConcept C159047783 @default.
- W2161182903 hasConcept C2522874641 @default.
- W2161182903 hasConcept C2775967933 @default.
- W2161182903 hasConcept C2777888124 @default.
- W2161182903 hasConcept C2778764654 @default.
- W2161182903 hasConcept C2779120600 @default.
- W2161182903 hasConcept C55493867 @default.
- W2161182903 hasConcept C67705224 @default.
- W2161182903 hasConcept C71924100 @default.
- W2161182903 hasConcept C86803240 @default.
- W2161182903 hasConceptScore W2161182903C104317684 @default.
- W2161182903 hasConceptScore W2161182903C126322002 @default.
- W2161182903 hasConceptScore W2161182903C134018914 @default.
- W2161182903 hasConceptScore W2161182903C140704245 @default.
- W2161182903 hasConceptScore W2161182903C142724271 @default.
- W2161182903 hasConceptScore W2161182903C159047783 @default.
- W2161182903 hasConceptScore W2161182903C2522874641 @default.
- W2161182903 hasConceptScore W2161182903C2775967933 @default.
- W2161182903 hasConceptScore W2161182903C2777888124 @default.
- W2161182903 hasConceptScore W2161182903C2778764654 @default.
- W2161182903 hasConceptScore W2161182903C2779120600 @default.
- W2161182903 hasConceptScore W2161182903C55493867 @default.
- W2161182903 hasConceptScore W2161182903C67705224 @default.
- W2161182903 hasConceptScore W2161182903C71924100 @default.
- W2161182903 hasConceptScore W2161182903C86803240 @default.
- W2161182903 hasIssue "4" @default.
- W2161182903 hasLocation W21611829031 @default.
- W2161182903 hasOpenAccess W2161182903 @default.
- W2161182903 hasPrimaryLocation W21611829031 @default.
- W2161182903 hasRelatedWork W1487857142 @default.
- W2161182903 hasRelatedWork W1608862421 @default.
- W2161182903 hasRelatedWork W1825162875 @default.
- W2161182903 hasRelatedWork W1986137505 @default.
- W2161182903 hasRelatedWork W2010478346 @default.
- W2161182903 hasRelatedWork W2086632997 @default.
- W2161182903 hasRelatedWork W2142935324 @default.
- W2161182903 hasRelatedWork W2157458496 @default.
- W2161182903 hasRelatedWork W2406270448 @default.
- W2161182903 hasRelatedWork W3165029026 @default.
- W2161182903 hasVolume "38" @default.