FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161185865> ?p ?o ?g. }

• W2161185865 endingPage "266" @default.
• W2161185865 startingPage "255" @default.
• W2161185865 abstract "Indole-3-carbinol (I3C), a natural autolysis product of a gluccosinolate present in Brassica vegetables such as broccoli and cabbage, has anti-proliferative and anti-estrogenic activities in human breast cancer cells. A new and significantly more potent I3C analogue, 1-benzyl-I3C was synthesized, and in comparison to I3C, this novel derivative displayed an approximate 1000-fold enhanced potency in suppressing the growth of both estrogen responsive (MCF-7) and estrogen-independent (MDA-MB-231) human breast cancer cells (I3C IC(50) of 52 microM, and 1-benzyl-I3C IC(50) of 0.05 microM). At significantly lower concentrations, 1-benzyl-I3C induced a robust G1 cell cycle arrest and elicited the key I3C-specific effects on expression and activity of G1-acting cell cycle genes including the disruption of endogenous interactions of the Sp1 transcription factor with the CDK6 promoter. Furthermore, in estrogen responsive MCF-7 cells, with enhanced potency 1-benzyl-I3C down-regulated production of estrogen receptor-alpha protein, acts with tamoxifen to arrest breast cancer cell growth more effectively than either compound alone, and inhibited the in vivo growth of human breast cancer cell-derived tumor xenografts in athymic mice. Our results implicate 1-benzyl-I3C as a novel, potent inhibitor of human breast cancer proliferation and estrogen responsiveness that could potentially be developed into a promising therapeutic agent for the treatment of indole-sensitive cancers." @default.
• W2161185865 created "2016-06-24" @default.
• W2161185865 creator A5008109270 @default.
• W2161185865 creator A5009774604 @default.
• W2161185865 creator A5023224521 @default.
• W2161185865 creator A5024375675 @default.
• W2161185865 creator A5030136467 @default.
• W2161185865 creator A5038263925 @default.
• W2161185865 creator A5039340406 @default.
• W2161185865 creator A5040785310 @default.
• W2161185865 creator A5047261135 @default.
• W2161185865 creator A5053781606 @default.
• W2161185865 creator A5078856545 @default.
• W2161185865 date "2010-08-01" @default.
• W2161185865 modified "2023-09-25" @default.
• W2161185865 title "1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells" @default.
• W2161185865 cites W140098831 @default.
• W2161185865 cites W1547327665 @default.
• W2161185865 cites W1969892814 @default.
• W2161185865 cites W1975773180 @default.
• W2161185865 cites W1979805598 @default.
• W2161185865 cites W1980537841 @default.
• W2161185865 cites W1999319510 @default.
• W2161185865 cites W2000889184 @default.
• W2161185865 cites W2006128340 @default.
• W2161185865 cites W2007864357 @default.
• W2161185865 cites W2010129088 @default.
• W2161185865 cites W2020771331 @default.
• W2161185865 cites W2029964395 @default.
• W2161185865 cites W2037116559 @default.
• W2161185865 cites W2037487283 @default.
• W2161185865 cites W2043620261 @default.
• W2161185865 cites W2044261960 @default.
• W2161185865 cites W2052902977 @default.
• W2161185865 cites W2054709033 @default.
• W2161185865 cites W2058673968 @default.
• W2161185865 cites W2063058393 @default.
• W2161185865 cites W2074130152 @default.
• W2161185865 cites W2074238448 @default.
• W2161185865 cites W2074249423 @default.
• W2161185865 cites W2076307754 @default.
• W2161185865 cites W2077613098 @default.
• W2161185865 cites W2090500595 @default.
• W2161185865 cites W2095963384 @default.
• W2161185865 cites W2096535726 @default.
• W2161185865 cites W2102199428 @default.
• W2161185865 cites W2104000690 @default.
• W2161185865 cites W2111559030 @default.
• W2161185865 cites W2128668884 @default.
• W2161185865 cites W2132533511 @default.
• W2161185865 cites W2135106611 @default.
• W2161185865 cites W2145954999 @default.
• W2161185865 cites W2155649041 @default.
• W2161185865 cites W4232454897 @default.
• W2161185865 cites W4253061118 @default.
• W2161185865 doi "https://doi.org/10.1016/j.cbi.2010.05.015" @default.
• W2161185865 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3422669" @default.
• W2161185865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20570586" @default.
• W2161185865 hasPublicationYear "2010" @default.
• W2161185865 type Work @default.
• W2161185865 sameAs 2161185865 @default.
• W2161185865 citedByCount "34" @default.
• W2161185865 countsByYear W21611858652012 @default.
• W2161185865 countsByYear W21611858652013 @default.
• W2161185865 countsByYear W21611858652014 @default.
• W2161185865 countsByYear W21611858652015 @default.
• W2161185865 countsByYear W21611858652016 @default.
• W2161185865 countsByYear W21611858652017 @default.
• W2161185865 countsByYear W21611858652018 @default.
• W2161185865 countsByYear W21611858652019 @default.
• W2161185865 countsByYear W21611858652020 @default.
• W2161185865 countsByYear W21611858652021 @default.
• W2161185865 countsByYear W21611858652023 @default.
• W2161185865 crossrefType "journal-article" @default.
• W2161185865 hasAuthorship W2161185865A5008109270 @default.
• W2161185865 hasAuthorship W2161185865A5009774604 @default.
• W2161185865 hasAuthorship W2161185865A5023224521 @default.
• W2161185865 hasAuthorship W2161185865A5024375675 @default.
• W2161185865 hasAuthorship W2161185865A5030136467 @default.
• W2161185865 hasAuthorship W2161185865A5038263925 @default.
• W2161185865 hasAuthorship W2161185865A5039340406 @default.
• W2161185865 hasAuthorship W2161185865A5040785310 @default.
• W2161185865 hasAuthorship W2161185865A5047261135 @default.
• W2161185865 hasAuthorship W2161185865A5053781606 @default.
• W2161185865 hasAuthorship W2161185865A5078856545 @default.
• W2161185865 hasBestOaLocation W21611858652 @default.
• W2161185865 hasConcept C105696609 @default.
• W2161185865 hasConcept C121608353 @default.
• W2161185865 hasConcept C126322002 @default.
• W2161185865 hasConcept C134018914 @default.
• W2161185865 hasConcept C1491633281 @default.
• W2161185865 hasConcept C185592680 @default.
• W2161185865 hasConcept C199649820 @default.
• W2161185865 hasConcept C2777164284 @default.
• W2161185865 hasConcept C2777176818 @default.
• W2161185865 hasConcept C29537977 @default.
• W2161185865 hasConcept C502942594 @default.
• W2161185865 hasConcept C530470458 @default.

• next