FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161201097> ?p ?o ?g. }

• W2161201097 endingPage "e10806" @default.
• W2161201097 startingPage "e10806" @default.
• W2161201097 abstract "Dopamine (DA) and serotonin (5HT) are reported to serve important roles in aggression in a wide variety of animals. Previous investigations of 5HT function in adult Drosophila behavior have relied on pharmacological manipulations, or on combinations of genetic tools that simultaneously target both DA and 5HT neurons. Here, we generated a transgenic line that allows selective, direct manipulation of serotonergic neurons and asked whether DA and 5HT have separable effects on aggression. Quantitative morphological examination demonstrated that our newly generated tryptophan hydroxylase (TRH)-Gal4 driver line was highly selective for 5HT-containing neurons. This line was used in conjunction with already available Gal4 driver lines that target DA or both DA and 5HT neurons to acutely alter the function of aminergic systems. First, we showed that acute impairment of DA and 5HT neurotransmission using expression of a temperature sensitive form of dynamin completely abolished mid- and high-level aggression. These flies did not escalate fights beyond brief low-intensity interactions and therefore did not yield dominance relationships. We showed next that manipulation of either 5HT or DA neurotransmission failed to duplicate this phenotype. Selective disruption of 5HT neurotransmission yielded flies that fought, but with reduced ability to escalate fights, leading to fewer dominance relationships. Acute activation of 5HT neurons using temperature sensitive dTrpA1 channel expression, in contrast, resulted in flies that escalated fights faster and that fought at higher intensities. Finally, acute disruption of DA neurotransmission produced hyperactive flies that moved faster than controls, and rarely engaged in any social interactions. By separately manipulating 5HT- and DA- neuron systems, we collected evidence demonstrating a direct role for 5HT in the escalation of aggression in Drosophila." @default.
• W2161201097 created "2016-06-24" @default.
• W2161201097 creator A5039613768 @default.
• W2161201097 creator A5069154943 @default.
• W2161201097 creator A5071542166 @default.
• W2161201097 date "2010-05-24" @default.
• W2161201097 modified "2023-10-09" @default.
• W2161201097 title "Targeted Manipulation of Serotonergic Neurotransmission Affects the Escalation of Aggression in Adult Male Drosophila melanogaster" @default.
• W2161201097 cites W1487589684 @default.
• W2161201097 cites W1552496397 @default.
• W2161201097 cites W1562036320 @default.
• W2161201097 cites W1598364670 @default.
• W2161201097 cites W1814633825 @default.
• W2161201097 cites W1878161105 @default.
• W2161201097 cites W1880904118 @default.
• W2161201097 cites W1882390972 @default.
• W2161201097 cites W1963498381 @default.
• W2161201097 cites W1971233799 @default.
• W2161201097 cites W1974212744 @default.
• W2161201097 cites W1981088221 @default.
• W2161201097 cites W1981372003 @default.
• W2161201097 cites W1991955609 @default.
• W2161201097 cites W1992288642 @default.
• W2161201097 cites W1997543121 @default.
• W2161201097 cites W1998073743 @default.
• W2161201097 cites W1998105194 @default.
• W2161201097 cites W1998906700 @default.
• W2161201097 cites W2000482977 @default.
• W2161201097 cites W2002342797 @default.
• W2161201097 cites W2004033705 @default.
• W2161201097 cites W2004739431 @default.
• W2161201097 cites W2011252910 @default.
• W2161201097 cites W2013846361 @default.
• W2161201097 cites W2014605680 @default.
• W2161201097 cites W2019534906 @default.
• W2161201097 cites W2022460284 @default.
• W2161201097 cites W2024508395 @default.
• W2161201097 cites W2029496968 @default.
• W2161201097 cites W2037917789 @default.
• W2161201097 cites W2040867180 @default.
• W2161201097 cites W2043203446 @default.
• W2161201097 cites W2046645924 @default.
• W2161201097 cites W2050756150 @default.
• W2161201097 cites W2050849483 @default.
• W2161201097 cites W2057705211 @default.
• W2161201097 cites W2058735778 @default.
• W2161201097 cites W2059367160 @default.
• W2161201097 cites W2060968828 @default.
• W2161201097 cites W2070566852 @default.
• W2161201097 cites W2070656240 @default.
• W2161201097 cites W2071190277 @default.
• W2161201097 cites W2071998635 @default.
• W2161201097 cites W2073092409 @default.
• W2161201097 cites W2077178820 @default.
• W2161201097 cites W2077191217 @default.
• W2161201097 cites W2085089624 @default.
• W2161201097 cites W2086636592 @default.
• W2161201097 cites W2088599563 @default.
• W2161201097 cites W2089049622 @default.
• W2161201097 cites W2089427933 @default.
• W2161201097 cites W2093312342 @default.
• W2161201097 cites W2093534366 @default.
• W2161201097 cites W2097601880 @default.
• W2161201097 cites W2097863680 @default.
• W2161201097 cites W2102557611 @default.
• W2161201097 cites W2104024903 @default.
• W2161201097 cites W2104947539 @default.
• W2161201097 cites W2107971067 @default.
• W2161201097 cites W2110643873 @default.
• W2161201097 cites W2111544501 @default.
• W2161201097 cites W2155747834 @default.
• W2161201097 cites W2156083131 @default.
• W2161201097 cites W2159618114 @default.
• W2161201097 cites W2160114821 @default.
• W2161201097 cites W2162412808 @default.
• W2161201097 cites W2171167182 @default.
• W2161201097 cites W4243414292 @default.
• W2161201097 doi "https://doi.org/10.1371/journal.pone.0010806" @default.
• W2161201097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2875409" @default.
• W2161201097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20520823" @default.
• W2161201097 hasPublicationYear "2010" @default.
• W2161201097 type Work @default.
• W2161201097 sameAs 2161201097 @default.
• W2161201097 citedByCount "196" @default.
• W2161201097 countsByYear W21612010972012 @default.
• W2161201097 countsByYear W21612010972013 @default.
• W2161201097 countsByYear W21612010972014 @default.
• W2161201097 countsByYear W21612010972015 @default.
• W2161201097 countsByYear W21612010972016 @default.
• W2161201097 countsByYear W21612010972017 @default.
• W2161201097 countsByYear W21612010972018 @default.
• W2161201097 countsByYear W21612010972019 @default.
• W2161201097 countsByYear W21612010972020 @default.
• W2161201097 countsByYear W21612010972021 @default.
• W2161201097 countsByYear W21612010972022 @default.
• W2161201097 countsByYear W21612010972023 @default.
• W2161201097 crossrefType "journal-article" @default.
• W2161201097 hasAuthorship W2161201097A5039613768 @default.

• next