Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161227864> ?p ?o ?g. }
- W2161227864 endingPage "449" @default.
- W2161227864 startingPage "440" @default.
- W2161227864 abstract "Upon DNA stimulation, cyclic GMP-AMP synthase (cGAS) synthesizes the second messenger cyclic GMP-AMP (cGAMP) that binds to the STING, triggering antiviral interferon-β (IFN-β) production. However, it has remained undetermined how hosts regulate cGAS enzymatic activity after the resolution of DNA immunogen. Here, we show that Akt kinase plays a negative role in cGAS-mediated anti-viral immune response. Akt phosphorylated the S291 or S305 residue of the enzymatic domain of mouse or human cGAS, respectively, and this phosphorylation robustly suppressed its enzymatic activity. Consequently, expression of activated Akt led to the reduction of cGAMP and IFN-β production and the increase of herpes simplex virus 1 replication, whereas treatment with Akt inhibitor augmented cGAS-mediated IFN-β production. Furthermore, expression of the phosphorylation-resistant cGAS S291A mutant enhanced IFN-β production upon DNA stimulation, HSV-1 infection, and vaccinia virus infection. Our study identifies an Akt kinase-mediated checkpoint to fine-tune hosts' immune responses to DNA stimulation." @default.
- W2161227864 created "2016-06-24" @default.
- W2161227864 creator A5022383655 @default.
- W2161227864 creator A5025300076 @default.
- W2161227864 creator A5027853327 @default.
- W2161227864 creator A5030805785 @default.
- W2161227864 creator A5062577168 @default.
- W2161227864 creator A5067029236 @default.
- W2161227864 creator A5067689954 @default.
- W2161227864 creator A5073721352 @default.
- W2161227864 creator A5077625021 @default.
- W2161227864 creator A5087483885 @default.
- W2161227864 date "2015-10-01" @default.
- W2161227864 modified "2023-10-16" @default.
- W2161227864 title "Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway" @default.
- W2161227864 cites W102230927 @default.
- W2161227864 cites W1513404509 @default.
- W2161227864 cites W1523693806 @default.
- W2161227864 cites W1552846692 @default.
- W2161227864 cites W1559117436 @default.
- W2161227864 cites W1591054413 @default.
- W2161227864 cites W1973268713 @default.
- W2161227864 cites W1974744480 @default.
- W2161227864 cites W1980923315 @default.
- W2161227864 cites W1984621921 @default.
- W2161227864 cites W1986536654 @default.
- W2161227864 cites W1993322661 @default.
- W2161227864 cites W1994826332 @default.
- W2161227864 cites W1994942139 @default.
- W2161227864 cites W1997069349 @default.
- W2161227864 cites W1997593996 @default.
- W2161227864 cites W2015310325 @default.
- W2161227864 cites W2016131266 @default.
- W2161227864 cites W2019186980 @default.
- W2161227864 cites W2025271427 @default.
- W2161227864 cites W2025732964 @default.
- W2161227864 cites W2028792773 @default.
- W2161227864 cites W2042288276 @default.
- W2161227864 cites W2042816890 @default.
- W2161227864 cites W2042950864 @default.
- W2161227864 cites W2048030072 @default.
- W2161227864 cites W2048246423 @default.
- W2161227864 cites W2049898530 @default.
- W2161227864 cites W2051419676 @default.
- W2161227864 cites W2085192138 @default.
- W2161227864 cites W2094920145 @default.
- W2161227864 cites W2097747132 @default.
- W2161227864 cites W2098854209 @default.
- W2161227864 cites W2099610218 @default.
- W2161227864 cites W2112241625 @default.
- W2161227864 cites W2112326573 @default.
- W2161227864 cites W2114691307 @default.
- W2161227864 cites W2116803339 @default.
- W2161227864 cites W2123645680 @default.
- W2161227864 cites W2131617804 @default.
- W2161227864 cites W2132413371 @default.
- W2161227864 cites W2135660738 @default.
- W2161227864 cites W2145082026 @default.
- W2161227864 cites W2150058561 @default.
- W2161227864 cites W2154171253 @default.
- W2161227864 cites W2158542519 @default.
- W2161227864 doi "https://doi.org/10.1016/j.celrep.2015.09.007" @default.
- W2161227864 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4607670" @default.
- W2161227864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26440888" @default.
- W2161227864 hasPublicationYear "2015" @default.
- W2161227864 type Work @default.
- W2161227864 sameAs 2161227864 @default.
- W2161227864 citedByCount "150" @default.
- W2161227864 countsByYear W21612278642016 @default.
- W2161227864 countsByYear W21612278642017 @default.
- W2161227864 countsByYear W21612278642018 @default.
- W2161227864 countsByYear W21612278642019 @default.
- W2161227864 countsByYear W21612278642020 @default.
- W2161227864 countsByYear W21612278642021 @default.
- W2161227864 countsByYear W21612278642022 @default.
- W2161227864 countsByYear W21612278642023 @default.
- W2161227864 crossrefType "journal-article" @default.
- W2161227864 hasAuthorship W2161227864A5022383655 @default.
- W2161227864 hasAuthorship W2161227864A5025300076 @default.
- W2161227864 hasAuthorship W2161227864A5027853327 @default.
- W2161227864 hasAuthorship W2161227864A5030805785 @default.
- W2161227864 hasAuthorship W2161227864A5062577168 @default.
- W2161227864 hasAuthorship W2161227864A5067029236 @default.
- W2161227864 hasAuthorship W2161227864A5067689954 @default.
- W2161227864 hasAuthorship W2161227864A5073721352 @default.
- W2161227864 hasAuthorship W2161227864A5077625021 @default.
- W2161227864 hasAuthorship W2161227864A5087483885 @default.
- W2161227864 hasBestOaLocation W21612278641 @default.
- W2161227864 hasConcept C11960822 @default.
- W2161227864 hasConcept C153911025 @default.
- W2161227864 hasConcept C159047783 @default.
- W2161227864 hasConcept C184235292 @default.
- W2161227864 hasConcept C2522874641 @default.
- W2161227864 hasConcept C2776178377 @default.
- W2161227864 hasConcept C2781196997 @default.
- W2161227864 hasConcept C62478195 @default.
- W2161227864 hasConcept C75217442 @default.
- W2161227864 hasConcept C86554907 @default.