Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161285087> ?p ?o ?g. }
- W2161285087 endingPage "638" @default.
- W2161285087 startingPage "632" @default.
- W2161285087 abstract "The enormous diversity of the antibody repertoire is generated by two mechanisms: recombination of immunoglobulin (Ig) gene variable (V), diversity (D), and joining (J) gene segments during the early stages of B-cell development in the bone marrow and somatic hypermutation (SHM) of functional Ig genes from antigen-activated B cells within secondary lymphoid organs. Diversity by V(D)J recombination and SHM not only provides protective humoral immunity but also generates potentially harmful clones expressing autoantibodies. Under normal circumstances, several mechanisms regulate the removal of autoreactive B cells and defects in central and peripheral B cell tolerance checkpoints are associated with the development of autoimmunity in humans." @default.
- W2161285087 created "2016-06-24" @default.
- W2161285087 creator A5012230366 @default.
- W2161285087 creator A5071215510 @default.
- W2161285087 date "2008-12-01" @default.
- W2161285087 modified "2023-10-01" @default.
- W2161285087 title "B-cell tolerance checkpoints in health and autoimmunity" @default.
- W2161285087 cites W1490715552 @default.
- W2161285087 cites W1496165222 @default.
- W2161285087 cites W1509881480 @default.
- W2161285087 cites W1692714928 @default.
- W2161285087 cites W1966851529 @default.
- W2161285087 cites W1966949480 @default.
- W2161285087 cites W1987677365 @default.
- W2161285087 cites W1988295223 @default.
- W2161285087 cites W1992707199 @default.
- W2161285087 cites W1994402720 @default.
- W2161285087 cites W1995025510 @default.
- W2161285087 cites W2003955248 @default.
- W2161285087 cites W2011136801 @default.
- W2161285087 cites W2016208323 @default.
- W2161285087 cites W2016808992 @default.
- W2161285087 cites W2021916493 @default.
- W2161285087 cites W2025220396 @default.
- W2161285087 cites W2025468907 @default.
- W2161285087 cites W2031026925 @default.
- W2161285087 cites W2031263707 @default.
- W2161285087 cites W2034271713 @default.
- W2161285087 cites W2034505316 @default.
- W2161285087 cites W2044983161 @default.
- W2161285087 cites W2046383867 @default.
- W2161285087 cites W2051321376 @default.
- W2161285087 cites W2058753589 @default.
- W2161285087 cites W2060489436 @default.
- W2161285087 cites W2067618246 @default.
- W2161285087 cites W2072320300 @default.
- W2161285087 cites W2076198413 @default.
- W2161285087 cites W2087470599 @default.
- W2161285087 cites W2091850111 @default.
- W2161285087 cites W2095927634 @default.
- W2161285087 cites W2097057955 @default.
- W2161285087 cites W2098497060 @default.
- W2161285087 cites W2100902428 @default.
- W2161285087 cites W2102352404 @default.
- W2161285087 cites W2111782126 @default.
- W2161285087 cites W2118268169 @default.
- W2161285087 cites W2118418739 @default.
- W2161285087 cites W2118994799 @default.
- W2161285087 cites W2122596811 @default.
- W2161285087 cites W2126641568 @default.
- W2161285087 cites W2126879008 @default.
- W2161285087 cites W2127132484 @default.
- W2161285087 cites W2129964640 @default.
- W2161285087 cites W2130658643 @default.
- W2161285087 cites W2134544592 @default.
- W2161285087 cites W2135792930 @default.
- W2161285087 cites W2136823772 @default.
- W2161285087 cites W2138216198 @default.
- W2161285087 cites W2141301927 @default.
- W2161285087 cites W2144298599 @default.
- W2161285087 cites W2148013458 @default.
- W2161285087 cites W2150591553 @default.
- W2161285087 cites W2158850359 @default.
- W2161285087 cites W2162800454 @default.
- W2161285087 cites W2166317148 @default.
- W2161285087 cites W2167252574 @default.
- W2161285087 cites W2170142229 @default.
- W2161285087 cites W4238558113 @default.
- W2161285087 doi "https://doi.org/10.1016/j.coi.2008.09.001" @default.
- W2161285087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18848883" @default.
- W2161285087 hasPublicationYear "2008" @default.
- W2161285087 type Work @default.
- W2161285087 sameAs 2161285087 @default.
- W2161285087 citedByCount "254" @default.
- W2161285087 countsByYear W21612850872012 @default.
- W2161285087 countsByYear W21612850872013 @default.
- W2161285087 countsByYear W21612850872014 @default.
- W2161285087 countsByYear W21612850872015 @default.
- W2161285087 countsByYear W21612850872016 @default.
- W2161285087 countsByYear W21612850872017 @default.
- W2161285087 countsByYear W21612850872018 @default.
- W2161285087 countsByYear W21612850872019 @default.
- W2161285087 countsByYear W21612850872020 @default.
- W2161285087 countsByYear W21612850872021 @default.
- W2161285087 countsByYear W21612850872022 @default.
- W2161285087 countsByYear W21612850872023 @default.
- W2161285087 crossrefType "journal-article" @default.
- W2161285087 hasAuthorship W2161285087A5012230366 @default.
- W2161285087 hasAuthorship W2161285087A5071215510 @default.
- W2161285087 hasConcept C104317684 @default.
- W2161285087 hasConcept C128526571 @default.
- W2161285087 hasConcept C137756551 @default.
- W2161285087 hasConcept C159654299 @default.
- W2161285087 hasConcept C163764329 @default.
- W2161285087 hasConcept C203014093 @default.
- W2161285087 hasConcept C2777016536 @default.
- W2161285087 hasConcept C2777702733 @default.
- W2161285087 hasConcept C2778453870 @default.