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• W2161287454 abstract "Before the human cortex is able to process sensory information, young postmitotic neurons must maintain occasional bursts of action-potential firing to attract and keep synaptic contacts, to drive gene expression, and to transition to mature membrane properties. Before birth, human subplate (SP) neurons are spontaneously active, displaying bursts of electrical activity (plateau depolarizations with action potentials). Using whole-cell recordings in acute cortical slices, we investigated the source of this early activity. The spontaneous depolarizations in human SP neurons at midgestation (17-23 gestational weeks) were not completely eliminated by tetrodotoxin--a drug that blocks action potential firing and network activity--or by antagonists of glutamatergic, GABAergic, or glycinergic synaptic transmission. We then turned our focus away from standard chemical synapses to connexin-based gap junctions and hemichannels. PCR and immunohistochemical analysis identified the presence of connexins (Cx26/Cx32/Cx36) in the human fetal cortex. However, the connexin-positive cells were not found in clusters but, rather, were dispersed in the SP zone. Also, gap junction-permeable dyes did not diffuse to neighboring cells, suggesting that SP neurons were not strongly coupled to other cells at this age. Application of the gap junction and hemichannel inhibitors octanol, flufenamic acid, and carbenoxolone significantly blocked spontaneous activity. The putative hemichannel antagonist lanthanum alone was a potent inhibitor of the spontaneous activity. Together, these data suggest that connexin hemichannels contribute to spontaneous depolarizations in the human fetal cortex during the second trimester of gestation." @default.
• W2161287454 created "2016-06-24" @default.
• W2161287454 creator A5022591970 @default.
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• W2161287454 creator A5071546456 @default.
• W2161287454 creator A5079324856 @default.
• W2161287454 creator A5084160155 @default.
• W2161287454 date "2014-09-02" @default.
• W2161287454 modified "2023-10-03" @default.
• W2161287454 title "Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex" @default.
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• W2161287454 doi "https://doi.org/10.1073/pnas.1405253111" @default.
• W2161287454 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4169969" @default.
• W2161287454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25197082" @default.
• W2161287454 hasPublicationYear "2014" @default.
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