FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161291611> ?p ?o ?g. }

• W2161291611 endingPage "896" @default.
• W2161291611 startingPage "886" @default.
• W2161291611 abstract "Rationale : Mitochondrial uncoupling proteins (UCPs) belong to a superfamily of mitochondrial anion transporters that uncouple ATP synthesis from oxidative phosphorylation and mitigates mitochondrial reactive oxygen species production. Objective : We assessed the hypothesis that UCP2 participates in central cardiovascular regulation by maintaining reactive oxygen species homeostasis in the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons that maintain vasomotor tone located. We also elucidated the molecular mechanisms that underlie transcriptional upregulation of UCP2 in response to oxidative stress in RVLM. Methods and Results : In Sprague–Dawley rats, transcriptional upregulation of UCP2 in RVLM by rosiglitazone, an activator of its transcription factor peroxisome proliferator-activated receptor (PPAR)γ, reduced mitochondrial hydrogen peroxide level in RVLM and systemic arterial pressure. Oxidative stress induced by microinjection of angiotensin II into RVLM augmented UCP2 mRNA or protein expression in RVLM, which was antagonized by comicroinjection of NADPH oxidase inhibitor (diphenyleneiodonium chloride), superoxide dismutase mimetic (tempol), or p38 mitogen-activated protein kinase inhibitor (SB203580) but not by extracellular signal-regulated kinase 1/2 inhibitor (U0126). Angiotensin II also induced phosphorylation of the PPARγ coactivator, PPARγ coactivator (PGC)-1α, and an increase in formation of PGC-1α/PPARγ complexes in a p38 mitogen-activated protein kinase–dependent manner. Intracerebroventricular infusion of angiotensin II promoted an increase in mitochondrial hydrogen peroxide production in RVLM and chronic pressor response, which was potentiated by gene knockdown of UCP2 but blunted by rosiglitazone. Conclusions : These results suggest that transcriptional upregulation of mitochondrial UCP2 in response to an elevation in superoxide plays an active role in feedback regulation of reactive oxygen species production in RVLM and neurogenic hypertension associated with chronic oxidative stress." @default.
• W2161291611 created "2016-06-24" @default.
• W2161291611 creator A5012483729 @default.
• W2161291611 creator A5030476074 @default.
• W2161291611 creator A5033766882 @default.
• W2161291611 creator A5061073629 @default.
• W2161291611 creator A5067438833 @default.
• W2161291611 creator A5080035611 @default.
• W2161291611 date "2009-10-23" @default.
• W2161291611 modified "2023-09-23" @default.
• W2161291611 title "Transcriptional Upregulation of Mitochondrial Uncoupling Protein 2 Protects Against Oxidative Stress-Associated Neurogenic Hypertension" @default.
• W2161291611 cites W1554017667 @default.
• W2161291611 cites W1573635199 @default.
• W2161291611 cites W1594539479 @default.
• W2161291611 cites W1977312306 @default.
• W2161291611 cites W1985977889 @default.
• W2161291611 cites W1989858587 @default.
• W2161291611 cites W1992678387 @default.
• W2161291611 cites W1995530131 @default.
• W2161291611 cites W1996255031 @default.
• W2161291611 cites W2001306570 @default.
• W2161291611 cites W2007274732 @default.
• W2161291611 cites W2008632158 @default.
• W2161291611 cites W2018750561 @default.
• W2161291611 cites W2024734804 @default.
• W2161291611 cites W2034244149 @default.
• W2161291611 cites W2034287553 @default.
• W2161291611 cites W2036573181 @default.
• W2161291611 cites W2041289197 @default.
• W2161291611 cites W2046566365 @default.
• W2161291611 cites W2053879170 @default.
• W2161291611 cites W2062344501 @default.
• W2161291611 cites W2062786004 @default.
• W2161291611 cites W2082629592 @default.
• W2161291611 cites W2084107123 @default.
• W2161291611 cites W2087743415 @default.
• W2161291611 cites W2088086126 @default.
• W2161291611 cites W2089386494 @default.
• W2161291611 cites W2097457805 @default.
• W2161291611 cites W2098108405 @default.
• W2161291611 cites W2112612224 @default.
• W2161291611 cites W2118110011 @default.
• W2161291611 cites W2119494775 @default.
• W2161291611 cites W2119523842 @default.
• W2161291611 cites W2124612466 @default.
• W2161291611 cites W2128802756 @default.
• W2161291611 cites W2162007164 @default.
• W2161291611 cites W2163097094 @default.
• W2161291611 cites W2164444293 @default.
• W2161291611 cites W2168975002 @default.
• W2161291611 doi "https://doi.org/10.1161/circresaha.109.199018" @default.
• W2161291611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19762685" @default.
• W2161291611 hasPublicationYear "2009" @default.
• W2161291611 type Work @default.
• W2161291611 sameAs 2161291611 @default.
• W2161291611 citedByCount "82" @default.
• W2161291611 countsByYear W21612916112012 @default.
• W2161291611 countsByYear W21612916112013 @default.
• W2161291611 countsByYear W21612916112014 @default.
• W2161291611 countsByYear W21612916112015 @default.
• W2161291611 countsByYear W21612916112016 @default.
• W2161291611 countsByYear W21612916112017 @default.
• W2161291611 countsByYear W21612916112018 @default.
• W2161291611 countsByYear W21612916112019 @default.
• W2161291611 countsByYear W21612916112020 @default.
• W2161291611 countsByYear W21612916112021 @default.
• W2161291611 countsByYear W21612916112022 @default.
• W2161291611 crossrefType "journal-article" @default.
• W2161291611 hasAuthorship W2161291611A5012483729 @default.
• W2161291611 hasAuthorship W2161291611A5030476074 @default.
• W2161291611 hasAuthorship W2161291611A5033766882 @default.
• W2161291611 hasAuthorship W2161291611A5061073629 @default.
• W2161291611 hasAuthorship W2161291611A5067438833 @default.
• W2161291611 hasAuthorship W2161291611A5080035611 @default.
• W2161291611 hasBestOaLocation W21612916111 @default.
• W2161291611 hasConcept C104317684 @default.
• W2161291611 hasConcept C126322002 @default.
• W2161291611 hasConcept C127561419 @default.
• W2161291611 hasConcept C134018914 @default.
• W2161291611 hasConcept C169415338 @default.
• W2161291611 hasConcept C170493617 @default.
• W2161291611 hasConcept C184235292 @default.
• W2161291611 hasConcept C185592680 @default.
• W2161291611 hasConcept C2776151105 @default.
• W2161291611 hasConcept C2777229759 @default.
• W2161291611 hasConcept C2777953023 @default.
• W2161291611 hasConcept C2779719074 @default.
• W2161291611 hasConcept C28859421 @default.
• W2161291611 hasConcept C2908929049 @default.
• W2161291611 hasConcept C33114225 @default.
• W2161291611 hasConcept C48349386 @default.
• W2161291611 hasConcept C55493867 @default.
• W2161291611 hasConcept C71924100 @default.
• W2161291611 hasConcept C84393581 @default.
• W2161291611 hasConcept C86803240 @default.
• W2161291611 hasConcept C95444343 @default.
• W2161291611 hasConcept C97029542 @default.
• W2161291611 hasConceptScore W2161291611C104317684 @default.

• next