FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161294654> ?p ?o ?g. }

• W2161294654 endingPage "431" @default.
• W2161294654 startingPage "421" @default.
• W2161294654 abstract "3,4-(±)-Methylenedioxymethamphetamine (MDMA) is a ring-substituted amphetamine derivative with potent psychostimulant properties. The neuropharmacological effects of MDMA are biphasic in nature, initially causing synaptic monoamine release, primarily of serotonin (5-HT), inducing thermogenesis and hyperactivity (5-HT syndrome). The long-term effects of MDMA manifest as a prolonged depletion in 5-HT, and structural damage to 5-HT nerve terminals. MDMA toxicity is in part mediated by an ability to inhibit the presynaptic 5-HT reuptake transporter (SERT). Using a SERT-knockout (SERT-KO) rat model, we determined the impact of SERT deficiency on thermoregulation, locomotor activity, and neurotoxicity in SERT-KO or Wistar-based wild-type (WT) rats exposed to MDMA. WT and SERT-KO animals exhibited the highest thermogenic responses to MDMA (four times 10 mg/kg, sc at 12 h intervals) during the diurnal (first and third) doses according to peak body temperature and area under the curve (∑°C × h) analysis. Although no differences in peak body temperature were observed between MDMA-treated WT and SERT-KO animals, ∑°C × h following the first MDMA dose was reduced in SERT-KO rats. Exposure to a single dose of MDMA stimulated horizontal velocity in both WT and SERT-KO rats, however, this effect was delayed and attenuated in the KO animals. Finally, SERT-KO rats were insensitive to MDMA-induced long-term (7 days) depletions in 5-HT and its metabolite, 5-hydroxyindole acetic acid, in both cortex and striatum. In conclusion, SERT deficiency modulated MDMA-mediated thermogenesis, hyperactivity and neurotoxicity in KO rats. The data confirm that the SERT is essential for the manifestation of the acute and long-term toxicities of MDMA." @default.
• W2161294654 created "2016-06-24" @default.
• W2161294654 creator A5010399141 @default.
• W2161294654 creator A5031605226 @default.
• W2161294654 creator A5060909286 @default.
• W2161294654 creator A5060996003 @default.
• W2161294654 creator A5086522629 @default.
• W2161294654 creator A5091188351 @default.
• W2161294654 date "2014-03-04" @default.
• W2161294654 modified "2023-09-27" @default.
• W2161294654 title "Serotonin Reuptake Transporter Deficiency Modulates the Acute Thermoregulatory and Locomotor Activity Response to 3,4-(±)-Methylenedioxymethamphetamine, and Attenuates Depletions in Serotonin Levels in SERT-KO Rats" @default.
• W2161294654 cites W1521791862 @default.
• W2161294654 cites W1693348571 @default.
• W2161294654 cites W1917168084 @default.
• W2161294654 cites W1932668123 @default.
• W2161294654 cites W1960526592 @default.
• W2161294654 cites W1963510892 @default.
• W2161294654 cites W1968241182 @default.
• W2161294654 cites W1972349079 @default.
• W2161294654 cites W1973126788 @default.
• W2161294654 cites W1973256378 @default.
• W2161294654 cites W1976456595 @default.
• W2161294654 cites W1986988181 @default.
• W2161294654 cites W1989796311 @default.
• W2161294654 cites W1990508321 @default.
• W2161294654 cites W1994094794 @default.
• W2161294654 cites W1999266594 @default.
• W2161294654 cites W2008282906 @default.
• W2161294654 cites W2019474799 @default.
• W2161294654 cites W2025984201 @default.
• W2161294654 cites W2042004687 @default.
• W2161294654 cites W2047944520 @default.
• W2161294654 cites W2058340335 @default.
• W2161294654 cites W2059360851 @default.
• W2161294654 cites W2073979670 @default.
• W2161294654 cites W2076211114 @default.
• W2161294654 cites W2078046027 @default.
• W2161294654 cites W2082986500 @default.
• W2161294654 cites W2090563027 @default.
• W2161294654 cites W2090730172 @default.
• W2161294654 cites W2106966110 @default.
• W2161294654 cites W2109698385 @default.
• W2161294654 cites W2111112265 @default.
• W2161294654 cites W2118438870 @default.
• W2161294654 cites W2120113858 @default.
• W2161294654 cites W2135385264 @default.
• W2161294654 cites W2148562084 @default.
• W2161294654 cites W2151312380 @default.
• W2161294654 cites W2317019713 @default.
• W2161294654 cites W70337943 @default.
• W2161294654 doi "https://doi.org/10.1093/toxsci/kfu039" @default.
• W2161294654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4031621" @default.
• W2161294654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24595820" @default.
• W2161294654 hasPublicationYear "2014" @default.
• W2161294654 type Work @default.
• W2161294654 sameAs 2161294654 @default.
• W2161294654 citedByCount "15" @default.
• W2161294654 countsByYear W21612946542014 @default.
• W2161294654 countsByYear W21612946542015 @default.
• W2161294654 countsByYear W21612946542016 @default.
• W2161294654 countsByYear W21612946542017 @default.
• W2161294654 countsByYear W21612946542018 @default.
• W2161294654 countsByYear W21612946542019 @default.
• W2161294654 countsByYear W21612946542020 @default.
• W2161294654 countsByYear W21612946542021 @default.
• W2161294654 countsByYear W21612946542022 @default.
• W2161294654 crossrefType "journal-article" @default.
• W2161294654 hasAuthorship W2161294654A5010399141 @default.
• W2161294654 hasAuthorship W2161294654A5031605226 @default.
• W2161294654 hasAuthorship W2161294654A5060909286 @default.
• W2161294654 hasAuthorship W2161294654A5060996003 @default.
• W2161294654 hasAuthorship W2161294654A5086522629 @default.
• W2161294654 hasAuthorship W2161294654A5091188351 @default.
• W2161294654 hasBestOaLocation W21612946542 @default.
• W2161294654 hasConcept C126322002 @default.
• W2161294654 hasConcept C134018914 @default.
• W2161294654 hasConcept C170493617 @default.
• W2161294654 hasConcept C185592680 @default.
• W2161294654 hasConcept C187714386 @default.
• W2161294654 hasConcept C2775864247 @default.
• W2161294654 hasConcept C2776219046 @default.
• W2161294654 hasConcept C2777193897 @default.
• W2161294654 hasConcept C2778897192 @default.
• W2161294654 hasConcept C2779491297 @default.
• W2161294654 hasConcept C2780876324 @default.
• W2161294654 hasConcept C29730261 @default.
• W2161294654 hasConcept C31487548 @default.
• W2161294654 hasConcept C513476851 @default.
• W2161294654 hasConcept C529278444 @default.
• W2161294654 hasConcept C71924100 @default.
• W2161294654 hasConcept C98274493 @default.
• W2161294654 hasConcept C99631742 @default.
• W2161294654 hasConceptScore W2161294654C126322002 @default.
• W2161294654 hasConceptScore W2161294654C134018914 @default.
• W2161294654 hasConceptScore W2161294654C170493617 @default.
• W2161294654 hasConceptScore W2161294654C185592680 @default.
• W2161294654 hasConceptScore W2161294654C187714386 @default.
• W2161294654 hasConceptScore W2161294654C2775864247 @default.

• next