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- W2161298894 abstract "The mammalian brain contains a population of neurons that are continuously generated from late embryogenesis through adulthood-after the generation of almost all other neuronal types. This brain region-the hippocampal dentate gyrus-is in a sense, therefore, persistently immature. Postnatal and adult neurogenesis is likely an essential feature of the dentate, which is critical for learning and memory. Protracted neurogenesis after birth would allow the new cells to develop in conjunction with external events-but it may come with a price: while neurogenesis in utero occurs in a protected environment, children and adults are exposed to any number of hazards, such as toxins and infectious agents. Mature neurons might be resistant to such exposures, but new neurons may be vulnerable. Consistent with this prediction, in adult rodents seizures disrupt the integration of newly generated granule cells, whereas mature granule cells are comparatively unaffected. Significantly, abnormally interconnected cells may contribute to epileptogenesis and/or associated cognitive and memory deficits. Finally, studies increasingly indicate that new granule cells are extremely sensitive to a host of endogenous and exogenous factors, raising the possibility that disrupted granule cell integration may be a common feature of many neurological diseases." @default.
- W2161298894 created "2016-06-24" @default.
- W2161298894 creator A5059697093 @default.
- W2161298894 date "2007-11-16" @default.
- W2161298894 modified "2023-09-30" @default.
- W2161298894 title "Postnatal and Adult Neurogenesis in the Development of Human Disease" @default.
- W2161298894 cites W1483619155 @default.
- W2161298894 cites W1487386905 @default.
- W2161298894 cites W1488872763 @default.
- W2161298894 cites W1527585999 @default.
- W2161298894 cites W1530683023 @default.
- W2161298894 cites W1564102226 @default.
- W2161298894 cites W1581458838 @default.
- W2161298894 cites W1607484169 @default.
- W2161298894 cites W1670625131 @default.
- W2161298894 cites W1775250759 @default.
- W2161298894 cites W1847277954 @default.
- W2161298894 cites W1883162734 @default.
- W2161298894 cites W1963730891 @default.
- W2161298894 cites W1963940970 @default.
- W2161298894 cites W1964173716 @default.
- W2161298894 cites W1964326082 @default.
- W2161298894 cites W1966354382 @default.
- W2161298894 cites W1969363559 @default.
- W2161298894 cites W1971004772 @default.
- W2161298894 cites W1971275801 @default.
- W2161298894 cites W1971412104 @default.
- W2161298894 cites W1974451504 @default.
- W2161298894 cites W1979094225 @default.
- W2161298894 cites W1979612418 @default.
- W2161298894 cites W1980499453 @default.
- W2161298894 cites W1981279518 @default.
- W2161298894 cites W1985645482 @default.
- W2161298894 cites W1987375164 @default.
- W2161298894 cites W1990161015 @default.
- W2161298894 cites W1994345197 @default.
- W2161298894 cites W1999867125 @default.
- W2161298894 cites W2001904944 @default.
- W2161298894 cites W2002073425 @default.
- W2161298894 cites W2002720922 @default.
- W2161298894 cites W2005078834 @default.
- W2161298894 cites W2006255780 @default.
- W2161298894 cites W2006624547 @default.
- W2161298894 cites W2006985248 @default.
- W2161298894 cites W2007527697 @default.
- W2161298894 cites W2013137971 @default.
- W2161298894 cites W2013235905 @default.
- W2161298894 cites W2013705793 @default.
- W2161298894 cites W2013836023 @default.
- W2161298894 cites W2014140314 @default.
- W2161298894 cites W2015639930 @default.
- W2161298894 cites W2016456825 @default.
- W2161298894 cites W2021078847 @default.
- W2161298894 cites W2024397074 @default.
- W2161298894 cites W2025561202 @default.
- W2161298894 cites W2025604203 @default.
- W2161298894 cites W2026767613 @default.
- W2161298894 cites W202677935 @default.
- W2161298894 cites W2026780520 @default.
- W2161298894 cites W2027423193 @default.
- W2161298894 cites W2027937638 @default.
- W2161298894 cites W2028620081 @default.
- W2161298894 cites W2033333756 @default.
- W2161298894 cites W2035562497 @default.
- W2161298894 cites W2036125522 @default.
- W2161298894 cites W2037701234 @default.
- W2161298894 cites W2037885959 @default.
- W2161298894 cites W2042154782 @default.
- W2161298894 cites W2043772793 @default.
- W2161298894 cites W2046448671 @default.
- W2161298894 cites W2046501984 @default.
- W2161298894 cites W2046708720 @default.
- W2161298894 cites W2048691245 @default.
- W2161298894 cites W2052223075 @default.
- W2161298894 cites W2052543845 @default.
- W2161298894 cites W2053326179 @default.
- W2161298894 cites W2053965650 @default.
- W2161298894 cites W2054261786 @default.
- W2161298894 cites W2054552572 @default.
- W2161298894 cites W2055314834 @default.
- W2161298894 cites W2055625569 @default.
- W2161298894 cites W2056123267 @default.
- W2161298894 cites W2059220544 @default.
- W2161298894 cites W2063024365 @default.
- W2161298894 cites W2063496441 @default.
- W2161298894 cites W2067128446 @default.
- W2161298894 cites W2067856703 @default.
- W2161298894 cites W2068487027 @default.
- W2161298894 cites W2072182951 @default.
- W2161298894 cites W2075830803 @default.
- W2161298894 cites W2075949847 @default.
- W2161298894 cites W2076733450 @default.
- W2161298894 cites W2077110494 @default.
- W2161298894 cites W2079156156 @default.
- W2161298894 cites W2081322647 @default.
- W2161298894 cites W2084104345 @default.
- W2161298894 cites W2089635906 @default.
- W2161298894 cites W2091016720 @default.