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- W2161307536 abstract "Bone morphogenic protein (BMP) signaling is essential for the coordinated assembly of the synapse, but we know little about how BMP signaling is modulated in neurons. Our findings indicate that the Nemo (Nmo) kinase modulates BMP signaling in motor neurons. nmo mutants show synaptic structural defects at the Drosophila melanogaster larval neuromuscular junction, and providing Nmo in motor neurons rescues these defects. We show that Nmo and the BMP transcription factor Mad can be coimmunoprecipitated and find a genetic interaction between nmo and Mad mutants. Moreover, we demonstrate that Nmo is required for normal distribution and accumulation of phosphorylated Mad in motor neurons. Finally, our results indicate that Nmo phosphorylation of Mad at its N terminus, distinct from the BMP phosphorylation site, is required for normal function of Mad. Based on our findings, we propose a model in which phosphorylation of Mad by Nmo ensures normal accumulation and distribution of Mad and thereby fine tunes BMP signaling in motor neurons." @default.
- W2161307536 created "2016-06-24" @default.
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- W2161307536 date "2009-05-18" @default.
- W2161307536 modified "2023-10-16" @default.
- W2161307536 title "Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila neuromuscular junction" @default.
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- W2161307536 doi "https://doi.org/10.1083/jcb.200809127" @default.
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