FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161330962> ?p ?o ?g. }

• W2161330962 endingPage "1588" @default.
• W2161330962 startingPage "1578" @default.
• W2161330962 abstract "RationaleVitamin D and vitamin D binding protein (DBP) have been associated with COPD and FEV1. There are limited data regarding emphysema and vitamin D and DBP.ObjectiveThis is a pilot study of a portion of the subjects in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study designed to examine the relationship between vitamin D status, DBP, FEV1 and emphysema in COPD patients.MethodsWe measured serum 25(OH)D and DBP in 498 ECLIPSE subjects. Subjects were distributed amongst smoker controls, non-smoker controls, and GOLD stages 2, 3 and 4. Within each GOLD stage, the subjects were equally divided amongst high and low emphysema burden. The associations between 25(OH)D, DBP, and free vitamin D with FEV1, CT-defined emphysema, biomarkers and clinical data including CT-measured bone attenuation were assessed.Measurements25(OH)D and DBP were measured using tandem mass spectroscopy and competitive enzyme-linked immunosorbent assay, respectively,Main result25(OH)D was correlated with FEV1 (p = 0.01) and with severity of emphysema (p < 0.01). 25(OH)D was also associated with six-minute walk (p = 0.02), bronchodilator response (p = 0.04), and Clara cell secretory protein (CC-16) (p = 0.01). 25(OH)D levels were not associated with CT-measured bone attenuation, however DBP was associated with bone attenuation in subjects with emphysema. DBP was not associated with FEV1 or emphysema. 25(OH)D and DBP were inversely associated (p = 0.01).ConclusionThis is the first study to demonstrate a relationship between emphysema and vitamin D. We also provide further evidence for a relationship between vitamin D and FEV1." @default.
• W2161330962 created "2016-06-24" @default.
• W2161330962 creator A5006118934 @default.
• W2161330962 creator A5012297897 @default.
• W2161330962 creator A5032165570 @default.
• W2161330962 creator A5046175017 @default.
• W2161330962 creator A5046940384 @default.
• W2161330962 creator A5047450563 @default.
• W2161330962 creator A5050425677 @default.
• W2161330962 creator A5062699123 @default.
• W2161330962 creator A5065113476 @default.
• W2161330962 creator A5082807784 @default.
• W2161330962 creator A5083270547 @default.
• W2161330962 creator A5083312029 @default.
• W2161330962 creator A5084648166 @default.
• W2161330962 creator A5085514125 @default.
• W2161330962 date "2013-10-01" @default.
• W2161330962 modified "2023-09-25" @default.
• W2161330962 title "Vitamin D, vitamin D binding protein, lung function and structure in COPD" @default.
• W2161330962 cites W1645379154 @default.
• W2161330962 cites W1870011663 @default.
• W2161330962 cites W1904840724 @default.
• W2161330962 cites W1971129285 @default.
• W2161330962 cites W1972181361 @default.
• W2161330962 cites W1980458261 @default.
• W2161330962 cites W1984758198 @default.
• W2161330962 cites W1985955872 @default.
• W2161330962 cites W1991027471 @default.
• W2161330962 cites W1993055974 @default.
• W2161330962 cites W1996282132 @default.
• W2161330962 cites W1996287932 @default.
• W2161330962 cites W1999702058 @default.
• W2161330962 cites W2030123571 @default.
• W2161330962 cites W2040861245 @default.
• W2161330962 cites W2054404145 @default.
• W2161330962 cites W2060335268 @default.
• W2161330962 cites W2068135986 @default.
• W2161330962 cites W2074252273 @default.
• W2161330962 cites W2076538453 @default.
• W2161330962 cites W2080551137 @default.
• W2161330962 cites W2088288340 @default.
• W2161330962 cites W2094354458 @default.
• W2161330962 cites W2097467471 @default.
• W2161330962 cites W2098756886 @default.
• W2161330962 cites W2099484515 @default.
• W2161330962 cites W2103010959 @default.
• W2161330962 cites W2106449126 @default.
• W2161330962 cites W2114301704 @default.
• W2161330962 cites W2117075813 @default.
• W2161330962 cites W2118149184 @default.
• W2161330962 cites W2121231290 @default.
• W2161330962 cites W2122515787 @default.
• W2161330962 cites W2130445180 @default.
• W2161330962 cites W2130462780 @default.
• W2161330962 cites W2136923459 @default.
• W2161330962 cites W2137025787 @default.
• W2161330962 cites W2140804784 @default.
• W2161330962 cites W2142096203 @default.
• W2161330962 cites W2147816256 @default.
• W2161330962 cites W2150208889 @default.
• W2161330962 cites W2162947611 @default.
• W2161330962 cites W2164158986 @default.
• W2161330962 cites W2165241920 @default.
• W2161330962 cites W2168315832 @default.
• W2161330962 cites W2171470819 @default.
• W2161330962 cites W2171676943 @default.
• W2161330962 doi "https://doi.org/10.1016/j.rmed.2013.05.010" @default.
• W2161330962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23809536" @default.
• W2161330962 hasPublicationYear "2013" @default.
• W2161330962 type Work @default.
• W2161330962 sameAs 2161330962 @default.
• W2161330962 citedByCount "40" @default.
• W2161330962 countsByYear W21613309622013 @default.
• W2161330962 countsByYear W21613309622014 @default.
• W2161330962 countsByYear W21613309622015 @default.
• W2161330962 countsByYear W21613309622016 @default.
• W2161330962 countsByYear W21613309622017 @default.
• W2161330962 countsByYear W21613309622018 @default.
• W2161330962 countsByYear W21613309622019 @default.
• W2161330962 countsByYear W21613309622020 @default.
• W2161330962 countsByYear W21613309622021 @default.
• W2161330962 countsByYear W21613309622022 @default.
• W2161330962 crossrefType "journal-article" @default.
• W2161330962 hasAuthorship W2161330962A5006118934 @default.
• W2161330962 hasAuthorship W2161330962A5012297897 @default.
• W2161330962 hasAuthorship W2161330962A5032165570 @default.
• W2161330962 hasAuthorship W2161330962A5046175017 @default.
• W2161330962 hasAuthorship W2161330962A5046940384 @default.
• W2161330962 hasAuthorship W2161330962A5047450563 @default.
• W2161330962 hasAuthorship W2161330962A5050425677 @default.
• W2161330962 hasAuthorship W2161330962A5062699123 @default.
• W2161330962 hasAuthorship W2161330962A5065113476 @default.
• W2161330962 hasAuthorship W2161330962A5082807784 @default.
• W2161330962 hasAuthorship W2161330962A5083270547 @default.
• W2161330962 hasAuthorship W2161330962A5083312029 @default.
• W2161330962 hasAuthorship W2161330962A5084648166 @default.
• W2161330962 hasAuthorship W2161330962A5085514125 @default.
• W2161330962 hasBestOaLocation W21613309621 @default.

• next