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• W2161356831 abstract "Novel DNA-sensor with enzymatic amplification of the signal has beendeveloped on the base of glassy carbon electrode modified with ds-DNA and horseradishperoxidase (HRP). Phenothiazine dyes Methylene Blue and Methylene Green were used aselectrochemical markers for the detection of sulfonamide and anthracycline preparationsable to interact with DNA. The biosensor signal related to HRP oxidation of the markersdepends on the relation between their bonded and readily oxidized forms which depends onthe nature and concentration of pharmaceuticals. Sulfonamides diminish surfaceconcentration of MB accessible for HRP reaction whereas anthracyclines releaseintercalated marker and increase the signal. The DNA-HRP sensor developed makes itpossible to detect down to 0.002 nmol L-1 of sulfamethoxazole, 0.1 nmol L-1 of sulfadiazine,0.01 nmol L-1 of sulfamethazine, 0.1 nmol L-1 of sulfaguanine, 0.05 μmol L-1 of rubomycinand 0.08 μmol L-1 of doxorubicin." @default.
• W2161356831 created "2016-06-24" @default.
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• W2161356831 date "2005-11-14" @default.
• W2161356831 modified "2023-09-28" @default.
• W2161356831 title "Amperometric DNA-Peroxidase Sensor for the Detection of Pharmaceutical Preparations" @default.
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• W2161356831 doi "https://doi.org/10.3390/s5060364" @default.
• W2161356831 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3933880" @default.
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