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- W2161400097 abstract "We tested Mg 2+ influence on experimental morphine‐induced pharmacodependence in rats. Morphine‐induced pharmacodependence model consists of progressively increased doses of morphine (M) (5 mgkg i.p until 90 mgkg i.p) during 10 days. Withdrawal syndrome was induced by naloxone (N) administration (1 mgkg, s.c.) on the 11 th day, 2 h after the last morphine administration. We evaluated and statistically interpreted symptoms from withdrawal syndrome. 2 groups received magnesium acetate (MgAc) 0.5 mEqkgday i.p. and 0.1 mEqkgday MgAc i.p. respectively during all 11 days of morphine‐induced pharmacodependence. Serum magnesium levels were determined by spectrophotometry. Data obtained show that MgAc significantly decreases symptoms from withdrawal syndrome (grooming 19.9 ± 2.1 in M + MgAc 0.5 mEqkgday vs. 33 ± 2.85 in M group, p < 0.01)." @default.
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- W2161400097 date "2004-03-01" @default.
- W2161400097 modified "2023-09-23" @default.
- W2161400097 title "Magnesium influence on morphine ‐‐ induced pharmacodependence in rats" @default.
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