FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161410278> ?p ?o ?g. }

• W2161410278 endingPage "276" @default.
• W2161410278 startingPage "263" @default.
• W2161410278 abstract "Multiple isoforms of type 1 hexokinase (HK1) are transcribed during spermatogenesis in the mouse, including at least three that are presumably germ cell specific: HK1-sa, HK1-sb, and HK1-sc. Each of these predicted proteins contains a common, germ cell-specific sequence that replaces the porin-binding domain found in somatic HK1. Although HK1 protein is present in mature sperm and is tyrosine phosphorylated, it is not known whether the various potential isoforms are differentially translated and localized within the developing germ cells and mature sperm. Using antipeptide antisera against unique regions of HK1-sa and HK1-sb, it was demonstrated that these isoforms were not found in pachytene spermatocytes, round spermatids, condensing spermatids, or sperm, suggesting that HK1-sa and HK1-sb are not translated during spermatogenesis. Immunoreactivity was detected in protein from round spermatids, condensing spermatids, and mature sperm using an antipeptide antiserum against the common, germ cell-specific region, suggesting that HK1-sc was the only germ cell-specific isoform present in these cells. Two-dimensional SDS-PAGE suggested that all of the sperm HK1-sc was tyrosine phosphorylated, and that the somatic HK1 isoform was not present. Immunoelectron microscopy revealed that HK1-sc was associated with the mitochondria and with the fibrous sheath of the flagellum and was found in discrete clusters in the region of the membranes of the sperm head. The unusual distribution of HK1-sc in sperm suggests novel functions, such as extramitochondrial energy production, and also demonstrates that a hexokinase without a classical porin-binding domain can localize to mitochondria." @default.
• W2161410278 created "2016-06-24" @default.
• W2161410278 creator A5017497606 @default.
• W2161410278 creator A5025662544 @default.
• W2161410278 creator A5028477326 @default.
• W2161410278 creator A5030438643 @default.
• W2161410278 creator A5061637086 @default.
• W2161410278 creator A5077520441 @default.
• W2161410278 creator A5086397371 @default.
• W2161410278 date "1998-02-01" @default.
• W2161410278 modified "2023-10-02" @default.
• W2161410278 title "Targeting of a Germ Cell-specific Type 1 Hexokinase Lacking a Porin-binding Domain to the Mitochondria as Well as to the Head and Fibrous Sheath of Murine Spermatozoa" @default.
• W2161410278 cites W1521702495 @default.
• W2161410278 cites W1528378220 @default.
• W2161410278 cites W1535077838 @default.
• W2161410278 cites W1553005451 @default.
• W2161410278 cites W1559768539 @default.
• W2161410278 cites W1606423922 @default.
• W2161410278 cites W1949772429 @default.
• W2161410278 cites W1972150527 @default.
• W2161410278 cites W1977461031 @default.
• W2161410278 cites W1985815362 @default.
• W2161410278 cites W1989789175 @default.
• W2161410278 cites W1996526886 @default.
• W2161410278 cites W1997021745 @default.
• W2161410278 cites W2001892434 @default.
• W2161410278 cites W2002444862 @default.
• W2161410278 cites W2006608774 @default.
• W2161410278 cites W2008976996 @default.
• W2161410278 cites W2014421381 @default.
• W2161410278 cites W2018289835 @default.
• W2161410278 cites W2019426588 @default.
• W2161410278 cites W2025360499 @default.
• W2161410278 cites W2031704853 @default.
• W2161410278 cites W2035165470 @default.
• W2161410278 cites W2035622733 @default.
• W2161410278 cites W2048389722 @default.
• W2161410278 cites W2055394225 @default.
• W2161410278 cites W2057865279 @default.
• W2161410278 cites W2065235858 @default.
• W2161410278 cites W2067884529 @default.
• W2161410278 cites W2070361351 @default.
• W2161410278 cites W2071348291 @default.
• W2161410278 cites W2076222021 @default.
• W2161410278 cites W2076289080 @default.
• W2161410278 cites W2078032385 @default.
• W2161410278 cites W2079734276 @default.
• W2161410278 cites W2082497364 @default.
• W2161410278 cites W2084163192 @default.
• W2161410278 cites W2086560719 @default.
• W2161410278 cites W2095987337 @default.
• W2161410278 cites W2100837269 @default.
• W2161410278 cites W2101410710 @default.
• W2161410278 cites W2104969978 @default.
• W2161410278 cites W2139151974 @default.
• W2161410278 cites W2157488384 @default.
• W2161410278 cites W2160107586 @default.
• W2161410278 cites W2164948016 @default.
• W2161410278 cites W2169162874 @default.
• W2161410278 cites W2183761882 @default.
• W2161410278 cites W2413015551 @default.
• W2161410278 cites W2419365590 @default.
• W2161410278 cites W4210472171 @default.
• W2161410278 cites W4243584423 @default.
• W2161410278 doi "https://doi.org/10.1091/mbc.9.2.263" @default.
• W2161410278 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/25249" @default.
• W2161410278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9450953" @default.
• W2161410278 hasPublicationYear "1998" @default.
• W2161410278 type Work @default.
• W2161410278 sameAs 2161410278 @default.
• W2161410278 citedByCount "122" @default.
• W2161410278 countsByYear W21614102782012 @default.
• W2161410278 countsByYear W21614102782013 @default.
• W2161410278 countsByYear W21614102782014 @default.
• W2161410278 countsByYear W21614102782015 @default.
• W2161410278 countsByYear W21614102782016 @default.
• W2161410278 countsByYear W21614102782017 @default.
• W2161410278 countsByYear W21614102782018 @default.
• W2161410278 countsByYear W21614102782019 @default.
• W2161410278 countsByYear W21614102782020 @default.
• W2161410278 countsByYear W21614102782021 @default.
• W2161410278 countsByYear W21614102782022 @default.
• W2161410278 crossrefType "journal-article" @default.
• W2161410278 hasAuthorship W2161410278A5017497606 @default.
• W2161410278 hasAuthorship W2161410278A5025662544 @default.
• W2161410278 hasAuthorship W2161410278A5028477326 @default.
• W2161410278 hasAuthorship W2161410278A5030438643 @default.
• W2161410278 hasAuthorship W2161410278A5061637086 @default.
• W2161410278 hasAuthorship W2161410278A5077520441 @default.
• W2161410278 hasAuthorship W2161410278A5086397371 @default.
• W2161410278 hasBestOaLocation W21614102782 @default.
• W2161410278 hasConcept C104317684 @default.
• W2161410278 hasConcept C123765429 @default.
• W2161410278 hasConcept C134018914 @default.
• W2161410278 hasConcept C134305767 @default.
• W2161410278 hasConcept C153911025 @default.
• W2161410278 hasConcept C2779122487 @default.
• W2161410278 hasConcept C2781087480 @default.

• next