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- W2161459211 abstract "The v-mil oncogene of the avian retrovirus MH2 is expressed as a fusion protein with viral gag determinants in infected cells. This P100gag-mil protein accounts for the proliferation of chicken embryo neuroretina cells (CNR) induced by MH2 in vitro. We constructed a series of mutants by in-frame deletions in different parts of the gag and mil domains and tested their ability to induce CNR growth. We show that gag sequences, as well as 200-base-pair 5' mil sequences, were not required to induce such a proliferation. However, gag sequences seem to contribute to a full proliferation of growing CNR. In contrast, deletions in the kinase domain abolish this induction. In particular, by deleting only 9 nucleotides localized around the unique SphI site of v-mil, we produced a totally inactive mutant (BalSp). This mutant directs the synthesis of a v-mil protein lacking the dipeptide Tyr-Leu, which is conserved in almost all the members of the large protein kinase family, and a histidine residue highly conserved in Ser-Thr protein kinase members." @default.
- W2161459211 created "2016-06-24" @default.
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- W2161459211 date "1988-08-01" @default.
- W2161459211 modified "2023-09-25" @default.
- W2161459211 title "Mapping by in vitro constructs of the P100gag-mil region, accounting for induction of chicken neuroretina cell proliferation" @default.
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- W2161459211 doi "https://doi.org/10.1128/jvi.62.8.2808-2816.1988" @default.
- W2161459211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/253715" @default.
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