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• W2161460147 abstract "The negative symptoms of schizophrenia have been associated with altered neural activity during both reward processing and cognitive processing. Even though increasing evidence suggests a strong interaction between these two domains, it has not been studied in relation to negative symptoms. To elucidate neural mechanisms of the reward-cognition interaction, we applied a letter variant of the n-back working memory task and varied the financial incentives for performance. In the interaction contrast, we found a significantly activated cluster in the rostral anterior cingulate cortex (ACC), the middle frontal gyrus, and the bilateral superior frontal gyrus. The interaction did not differ significantly between the patient group and a healthy control group, suggesting that patients with schizophrenia are on average able to integrate reward information and utilize this information to maximize cognitive performance. However within the patient group, we found a significant inverse correlation of ACC activity with the factor diminished expression. This finding is consistent with the model that a lack of available cognitive resources leads to diminished expression. We therefore argue that patients with diminished expression have difficulties in recruiting additional cognitive resources (as implemented in the ACC) in response to an anticipated reward. Due to this lack of cognitive resources, less processing capacity is available for effective expression, resulting in diminished expressive behavior." @default.
• W2161460147 created "2016-06-24" @default.
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• W2161460147 date "2015-10-01" @default.
• W2161460147 modified "2023-09-26" @default.
• W2161460147 title "Reward-dependent modulation of working memory is associated with negative symptoms in schizophrenia" @default.
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• W2161460147 doi "https://doi.org/10.1016/j.schres.2015.08.024" @default.
• W2161460147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26362736" @default.
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