FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161471945> ?p ?o ?g. }

• W2161471945 endingPage "75" @default.
• W2161471945 startingPage "69" @default.
• W2161471945 abstract "Distribution of Inhaled m ‐Xylene in Rat Brain and its Effect on GAB A a Receptor Binding: Takehiko Ito, et al. Faculty of Education, Okayama University —Organic solvents generally depress the central nervous system (CNS), similarly to volatile anesthetics. The precise mechanism of their action on the CNS, however, is not fully understood, and remains to be clarified. This study is focused on how inhaled m‐xylene distributes in the brain, and whether region specific change in GAB A a receptor binding takes place due to the exposure. To conduct this study, we first developed a simple exposure system suitable for inhalation experiments with small animals. Using this system, six‐week‐old male Sprague‐Dawley rats were exposed to m ‐xylene vapor (2000 ppm) 4 h/d, for 5 consecutive days. At the end of the exposure, m ‐xylene levels in four different regions of the brain were measured by head‐space gas chromatography. Also 14μm‐thick frozen sections of the brain were made, and [ 35 S] t‐butylbicyclophosphorothionate (TBPS) binding autoradiography was performed. Uneven distribution of m ‐xylene in the brain was observed. The concentration in the cerebellum (976 ± 93.4μg/g tissue) was the highest, while that in the cerebral cortex (467 ± 43.6μ/g tissue) was the lowest. [ 35 S]TBPS binding was significantly greater in the molecular layer of the cerebellum (control: 12.6 ± 0.64, m ‐xylene 16.0 ± 1.34 fmol/mg tissue). These results suggest that m ‐xylene is distributed unevenly in the rat brain, and acute exposure to m ‐xylene at a high concentration alters PSJTBPS binding, which may reflect changes in GABA A receptor characteristics." @default.
• W2161471945 created "2016-06-24" @default.
• W2161471945 creator A5002980899 @default.
• W2161471945 creator A5010137523 @default.
• W2161471945 creator A5025264930 @default.
• W2161471945 creator A5026656849 @default.
• W2161471945 date "2002-03-01" @default.
• W2161471945 modified "2023-09-25" @default.
• W2161471945 title "Distribution of Inhaled <i>m</i>‐Xylene in Rat Brain and its Effect on GAB A_A Receptor Binding" @default.
• W2161471945 cites W1684853394 @default.
• W2161471945 cites W1967111818 @default.
• W2161471945 cites W1974440428 @default.
• W2161471945 cites W1983621709 @default.
• W2161471945 cites W2002988341 @default.
• W2161471945 cites W2003264969 @default.
• W2161471945 cites W2024128126 @default.
• W2161471945 cites W2047250399 @default.
• W2161471945 cites W2055920071 @default.
• W2161471945 cites W2066882561 @default.
• W2161471945 cites W2079083206 @default.
• W2161471945 cites W2084443487 @default.
• W2161471945 cites W2098722858 @default.
• W2161471945 cites W2144090856 @default.
• W2161471945 cites W2428390994 @default.
• W2161471945 cites W4298407382 @default.
• W2161471945 doi "https://doi.org/10.1539/joh.44.69" @default.
• W2161471945 hasPublicationYear "2002" @default.
• W2161471945 type Work @default.
• W2161471945 sameAs 2161471945 @default.
• W2161471945 citedByCount "7" @default.
• W2161471945 countsByYear W21614719452015 @default.
• W2161471945 countsByYear W21614719452020 @default.
• W2161471945 countsByYear W21614719452023 @default.
• W2161471945 crossrefType "journal-article" @default.
• W2161471945 hasAuthorship W2161471945A5002980899 @default.
• W2161471945 hasAuthorship W2161471945A5010137523 @default.
• W2161471945 hasAuthorship W2161471945A5025264930 @default.
• W2161471945 hasAuthorship W2161471945A5026656849 @default.
• W2161471945 hasBestOaLocation W21614719451 @default.
• W2161471945 hasConcept C110121322 @default.
• W2161471945 hasConcept C116569031 @default.
• W2161471945 hasConcept C12554922 @default.
• W2161471945 hasConcept C126322002 @default.
• W2161471945 hasConcept C134306372 @default.
• W2161471945 hasConcept C161790260 @default.
• W2161471945 hasConcept C170493617 @default.
• W2161471945 hasConcept C178790620 @default.
• W2161471945 hasConcept C185592680 @default.
• W2161471945 hasConcept C2776396718 @default.
• W2161471945 hasConcept C2776954882 @default.
• W2161471945 hasConcept C2778142098 @default.
• W2161471945 hasConcept C2779652256 @default.
• W2161471945 hasConcept C2779896714 @default.
• W2161471945 hasConcept C2781041448 @default.
• W2161471945 hasConcept C2986936838 @default.
• W2161471945 hasConcept C33923547 @default.
• W2161471945 hasConcept C42219234 @default.
• W2161471945 hasConcept C529278444 @default.
• W2161471945 hasConcept C55493867 @default.
• W2161471945 hasConcept C71924100 @default.
• W2161471945 hasConcept C86803240 @default.
• W2161471945 hasConceptScore W2161471945C110121322 @default.
• W2161471945 hasConceptScore W2161471945C116569031 @default.
• W2161471945 hasConceptScore W2161471945C12554922 @default.
• W2161471945 hasConceptScore W2161471945C126322002 @default.
• W2161471945 hasConceptScore W2161471945C134306372 @default.
• W2161471945 hasConceptScore W2161471945C161790260 @default.
• W2161471945 hasConceptScore W2161471945C170493617 @default.
• W2161471945 hasConceptScore W2161471945C178790620 @default.
• W2161471945 hasConceptScore W2161471945C185592680 @default.
• W2161471945 hasConceptScore W2161471945C2776396718 @default.
• W2161471945 hasConceptScore W2161471945C2776954882 @default.
• W2161471945 hasConceptScore W2161471945C2778142098 @default.
• W2161471945 hasConceptScore W2161471945C2779652256 @default.
• W2161471945 hasConceptScore W2161471945C2779896714 @default.
• W2161471945 hasConceptScore W2161471945C2781041448 @default.
• W2161471945 hasConceptScore W2161471945C2986936838 @default.
• W2161471945 hasConceptScore W2161471945C33923547 @default.
• W2161471945 hasConceptScore W2161471945C42219234 @default.
• W2161471945 hasConceptScore W2161471945C529278444 @default.
• W2161471945 hasConceptScore W2161471945C55493867 @default.
• W2161471945 hasConceptScore W2161471945C71924100 @default.
• W2161471945 hasConceptScore W2161471945C86803240 @default.
• W2161471945 hasIssue "2" @default.
• W2161471945 hasLocation W21614719451 @default.
• W2161471945 hasOpenAccess W2161471945 @default.
• W2161471945 hasPrimaryLocation W21614719451 @default.
• W2161471945 hasRelatedWork W2024260091 @default.
• W2161471945 hasRelatedWork W2035164663 @default.
• W2161471945 hasRelatedWork W2041107699 @default.
• W2161471945 hasRelatedWork W2045055063 @default.
• W2161471945 hasRelatedWork W2048583863 @default.
• W2161471945 hasRelatedWork W2092861891 @default.
• W2161471945 hasRelatedWork W2160445432 @default.
• W2161471945 hasRelatedWork W2161471945 @default.
• W2161471945 hasRelatedWork W2417377353 @default.
• W2161471945 hasRelatedWork W4290359253 @default.
• W2161471945 hasVolume "44" @default.

• next