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- W2161478307 abstract "Endometrial carcinoma is the most common gynecologic malignancy in Western countries, with an overall annual incidence in the United States of 25 per 100,000, increasing to more than 85 per 100,000 in women 60 years or older. Because the majority of patients present with early-stagedisease,theprognosisofendometrialcarcinoma patients is generally good, with 5-year overall and cancerspecific survival rates of 80% to 85% and 90% to 95%. 1-4 Endometrial carcinoma is primarily a cancer of postmenopausalwomen,withconcurrentmorbiditiessuchasobesity, hypertension, and diabetes. Given the favorable outcome for the majority of cases, the challenge is to effectively select those patients at increased risk of relapse who might benefit from more extensive surgical procedures and adjuvant therapies, and to avoid overtreatment of low-risk cases that would be exposed unnecessarily to the risk of excess morbidity. Since the Gynecologic Oncology Group (GOG)-33 staging study, 5,6 which reported an overall 9% risk of pelvic lymph node metastases in clinical stage I endometrial cancer (25% for cases with outer-third myometrial invasion and 18% for grade 3 disease), gynecologic oncologists have advocated standard lymphadenectomy or sampling proceduresforallintermediate-andlow-riskendometrialcancer patients. It should be noted that GOG-33 included 12% patients, who at laparotomy were found to have macroscopic extrauterine disease; of these, 51% had pelvic metastases, and 23% had aortic node metastases. Among the patients without gross intraperitoneal spread, only 7% and 4% had positive pelvic or aortic nodes, respectively. Women at high risk ( 10%) for pelvic node metastasis were those with grade 3 and outer-third invasion, while all other cases had low to moderate ( 5% to 10%) risk. 6 This is in accordance with the COSA-NZ-UK trial, 7 which re" @default.
- W2161478307 created "2016-06-24" @default.
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- W2161478307 date "2005-06-01" @default.
- W2161478307 modified "2023-09-26" @default.
- W2161478307 title "Lymphadenectomy in Apparent Early-Stage Endometrial Carcinoma: Do Numbers Count?" @default.
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- W2161478307 doi "https://doi.org/10.1200/jco.2005.11.947" @default.
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