FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161504208> ?p ?o ?g. }

• W2161504208 endingPage "535" @default.
• W2161504208 startingPage "530" @default.
• W2161504208 abstract "Allegations of illicit hydrocodone use have been made against individuals who were taking physician-prescribed oral codeine but denied hydrocodone use. Drug detection was based on positive urine opiate immunoassay results with subsequent confirmation of hydrocodone by gas chromatography-mass spectrometry (GC-MS). In these cases, low concentrations of hydrocodone (approximately 100 ng/mL) were detected in urine specimens containing high concentrations of codeine (> 5000 ng/mL). Although hydrocodone has been reported to be a minor metabolite of codeine in humans, there has been little study of this unusual metabolic pathway. We investigated the occurrence of hydrocodone excretion in urine specimens of subjects who were administered codeine. In a controlled study, two African-American and three Caucasian male subjects were orally administered 60 mg/70 kg/day and 120 mg/70 kg/day of codeine sulfate on separate days. Urine specimens were collected prior to and for approximately 30-40 h following drug administration. In a second case study, a postoperative patient self-administered 960 mg/day (240 mg four times per day) of physician-prescribed oral codeine phosphate, and urine specimens were collected on the third day of the dosing regimen. Samples from both studies were extracted on copolymeric solid-phase columns and analyzed by GC-MS. In the controlled study, codeine was detected in the first post-drug-administration specimen from all subjects. Peak concentrations appeared at 2-5 h and ranged from 1475 to 61,695 ng/mL. Codeine was detected at concentrations above the 10-ng/mL limit of quantitation for the assay throughout the 40-h collection period. Hydrocodone was initially detected at 6-11 h following codeine administration and peaked at 10-18 h (32-135 ng/mL). Detection times for hydrocodone following oral codeine administration ranged from 6 h to the end of the collection period. Confirmation of hydrocodone in a urine specimen was always accompanied by codeine detection. Codeine and hydrocodone were detected in all specimens collected from the postoperative patient, and concentrations ranged from 2099 to 4020 and 47 to 129 ng/mL, respectively. Analyses of the codeine formulations administered to subjects revealed no hydrocodone present at the limit of detection of the assay (10 ng/mL). These data confirm that hydrocodone can be produced as a minor metabolite of codeine in humans and may be excreted in urine at concentrations as high as 11% of parent drug concentration. Consequently, the detection of minor amounts of hydrocodone in urine containing high concentrations of codeine should not be interpreted as evidence of hydrocodone abuse." @default.
• W2161504208 created "2016-06-24" @default.
• W2161504208 creator A5000016116 @default.
• W2161504208 creator A5074494877 @default.
• W2161504208 creator A5088248944 @default.
• W2161504208 creator A5089636480 @default.
• W2161504208 date "2000-10-01" @default.
• W2161504208 modified "2023-10-14" @default.
• W2161504208 title "Identification of Hydrocodone in Human Urine Following Controlled Codeine Administration" @default.
• W2161504208 cites W1189795309 @default.
• W2161504208 cites W1485755231 @default.
• W2161504208 cites W2018361595 @default.
• W2161504208 cites W2020601640 @default.
• W2161504208 cites W2029699123 @default.
• W2161504208 cites W2035923630 @default.
• W2161504208 cites W2082213480 @default.
• W2161504208 cites W2088045040 @default.
• W2161504208 cites W2095755089 @default.
• W2161504208 cites W2145658882 @default.
• W2161504208 cites W2155963507 @default.
• W2161504208 cites W2160479811 @default.
• W2161504208 cites W2895087986 @default.
• W2161504208 cites W3190590750 @default.
• W2161504208 cites W75938685 @default.
• W2161504208 cites W2311376664 @default.
• W2161504208 doi "https://doi.org/10.1093/jat/24.7.530" @default.
• W2161504208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11043655" @default.
• W2161504208 hasPublicationYear "2000" @default.
• W2161504208 type Work @default.
• W2161504208 sameAs 2161504208 @default.
• W2161504208 citedByCount "67" @default.
• W2161504208 countsByYear W21615042082012 @default.
• W2161504208 countsByYear W21615042082013 @default.
• W2161504208 countsByYear W21615042082014 @default.
• W2161504208 countsByYear W21615042082015 @default.
• W2161504208 countsByYear W21615042082016 @default.
• W2161504208 countsByYear W21615042082017 @default.
• W2161504208 countsByYear W21615042082018 @default.
• W2161504208 countsByYear W21615042082019 @default.
• W2161504208 countsByYear W21615042082020 @default.
• W2161504208 countsByYear W21615042082021 @default.
• W2161504208 crossrefType "journal-article" @default.
• W2161504208 hasAuthorship W2161504208A5000016116 @default.
• W2161504208 hasAuthorship W2161504208A5074494877 @default.
• W2161504208 hasAuthorship W2161504208A5088248944 @default.
• W2161504208 hasAuthorship W2161504208A5089636480 @default.
• W2161504208 hasBestOaLocation W21615042081 @default.
• W2161504208 hasConcept C126322002 @default.
• W2161504208 hasConcept C170493617 @default.
• W2161504208 hasConcept C2776029756 @default.
• W2161504208 hasConcept C2776389719 @default.
• W2161504208 hasConcept C2777389121 @default.
• W2161504208 hasConcept C2777866328 @default.
• W2161504208 hasConcept C2779158186 @default.
• W2161504208 hasConcept C2780026642 @default.
• W2161504208 hasConcept C2781063702 @default.
• W2161504208 hasConcept C71924100 @default.
• W2161504208 hasConcept C98274493 @default.
• W2161504208 hasConceptScore W2161504208C126322002 @default.
• W2161504208 hasConceptScore W2161504208C170493617 @default.
• W2161504208 hasConceptScore W2161504208C2776029756 @default.
• W2161504208 hasConceptScore W2161504208C2776389719 @default.
• W2161504208 hasConceptScore W2161504208C2777389121 @default.
• W2161504208 hasConceptScore W2161504208C2777866328 @default.
• W2161504208 hasConceptScore W2161504208C2779158186 @default.
• W2161504208 hasConceptScore W2161504208C2780026642 @default.
• W2161504208 hasConceptScore W2161504208C2781063702 @default.
• W2161504208 hasConceptScore W2161504208C71924100 @default.
• W2161504208 hasConceptScore W2161504208C98274493 @default.
• W2161504208 hasIssue "7" @default.
• W2161504208 hasLocation W21615042081 @default.
• W2161504208 hasLocation W21615042082 @default.
• W2161504208 hasOpenAccess W2161504208 @default.
• W2161504208 hasPrimaryLocation W21615042081 @default.
• W2161504208 hasRelatedWork W1992209480 @default.
• W2161504208 hasRelatedWork W2029445962 @default.
• W2161504208 hasRelatedWork W2111599637 @default.
• W2161504208 hasRelatedWork W2154193845 @default.
• W2161504208 hasRelatedWork W2155963507 @default.
• W2161504208 hasRelatedWork W2313448209 @default.
• W2161504208 hasRelatedWork W2772467878 @default.
• W2161504208 hasRelatedWork W2891297835 @default.
• W2161504208 hasRelatedWork W2941629973 @default.
• W2161504208 hasRelatedWork W2339550639 @default.
• W2161504208 hasVolume "24" @default.
• W2161504208 isParatext "false" @default.
• W2161504208 isRetracted "false" @default.
• W2161504208 magId "2161504208" @default.
• W2161504208 workType "article" @default.