FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161511621> ?p ?o ?g. }

• W2161511621 endingPage "351" @default.
• W2161511621 startingPage "341" @default.
• W2161511621 abstract "To examine the potential utility of fucosylation of drug carriers for targeted drug delivery to Kupffer cells, the pharmacokinetics of 111In-labeled fucosylated bovine serum albumin (Fuc-BSA) with different numbers of fucose residues (11, 16, 25, 31 or 41) was studied. After intravenous injection in mice, all 111In-Fuc-BSAs were mainly delivered to the liver and their hepatic uptake became saturated when the dose was increased. Of these derivatives, only 111In-Fuc41-BSA showed a slow plasma elimination at low doses, suggesting an interaction with blood components. Examination of binding conditions as well as electrophoretic analysis of the binding components indicated that the serum-type mannan binding protein (MBP) is responsible. Kupffer cells, which possess fucose receptors, showed the highest uptake of 111In-Fuc41-BSA, followed by endothelial cells and hepatocytes. The hepatic uptake of 111In-Fuc41-BSA was inhibited by co-injection of Gal42-BSA, but not by Man46-BSA. On the other hand, excess Fuc41BSA inhibited the hepatic uptake of 111In-Man46-BSA, while 111In-Gal42-BSA did not: These findings suggest that not only the fucose receptors on Kupffer cells but also other lectins are involved in the biodistribution of Fuc-BSAs. To understand how the degree of fucose modification affects the binding affinity of Fuc-BSA with hepatic lectins and serum MBP, a pharmacokinetic analysis was performed based on a physiological model. The Michaelis constant of the hepatic uptake of 111in-Fuc-BSA decreased with an increasing number of fucose units, and the intrinsic hepatic clearance of 111In-Fuc25-, 111In-Fuc31- and 111 In-Fuc41-BSAs was close to, or much greater than, the hepatic plasma flow rate, indicating efficient hepatic uptake of these derivatives. These results suggest that fucosylation is a potentially useful method making drug carriers selective for Kupffer cells, although extensive modification might result in retarded delivery due to binding to other lectins like MBP." @default.
• W2161511621 created "2016-06-24" @default.
• W2161511621 creator A5011581277 @default.
• W2161511621 creator A5035791716 @default.
• W2161511621 creator A5071041099 @default.
• W2161511621 creator A5082694156 @default.
• W2161511621 creator A5091285288 @default.
• W2161511621 date "2001-01-01" @default.
• W2161511621 modified "2023-10-16" @default.
• W2161511621 title "Pharmacokinetic Analysis of Lectin-dependent Biodistribution of Fucosylated Bovine Serum Albumin: A Possible Carrier for Kupffer Cells" @default.
• W2161511621 cites W1511046127 @default.
• W2161511621 cites W1528557572 @default.
• W2161511621 cites W1532383318 @default.
• W2161511621 cites W1543454781 @default.
• W2161511621 cites W1547427125 @default.
• W2161511621 cites W1561078613 @default.
• W2161511621 cites W1581448994 @default.
• W2161511621 cites W1775749144 @default.
• W2161511621 cites W1946566829 @default.
• W2161511621 cites W1971042260 @default.
• W2161511621 cites W1989961111 @default.
• W2161511621 cites W2000384512 @default.
• W2161511621 cites W2005420965 @default.
• W2161511621 cites W2022401861 @default.
• W2161511621 cites W2028025223 @default.
• W2161511621 cites W2043671974 @default.
• W2161511621 cites W2044365536 @default.
• W2161511621 cites W2057330661 @default.
• W2161511621 cites W2060201297 @default.
• W2161511621 cites W2060701999 @default.
• W2161511621 cites W2067808410 @default.
• W2161511621 cites W2072982978 @default.
• W2161511621 cites W2079190294 @default.
• W2161511621 cites W2079276084 @default.
• W2161511621 cites W2086336057 @default.
• W2161511621 cites W2087968820 @default.
• W2161511621 cites W2095871350 @default.
• W2161511621 cites W2100837269 @default.
• W2161511621 cites W2130454747 @default.
• W2161511621 cites W2146586986 @default.
• W2161511621 cites W2160327135 @default.
• W2161511621 cites W2162291117 @default.
• W2161511621 cites W2171130683 @default.
• W2161511621 cites W2175128997 @default.
• W2161511621 cites W2275036883 @default.
• W2161511621 cites W228049032 @default.
• W2161511621 cites W295196760 @default.
• W2161511621 cites W4243464438 @default.
• W2161511621 cites W4252776746 @default.
• W2161511621 cites W48902376 @default.
• W2161511621 doi "https://doi.org/10.3109/10611860108998770" @default.
• W2161511621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11770704" @default.
• W2161511621 hasPublicationYear "2001" @default.
• W2161511621 type Work @default.
• W2161511621 sameAs 2161511621 @default.
• W2161511621 citedByCount "29" @default.
• W2161511621 countsByYear W21615116212012 @default.
• W2161511621 countsByYear W21615116212013 @default.
• W2161511621 countsByYear W21615116212014 @default.
• W2161511621 countsByYear W21615116212015 @default.
• W2161511621 countsByYear W21615116212016 @default.
• W2161511621 countsByYear W21615116212018 @default.
• W2161511621 countsByYear W21615116212019 @default.
• W2161511621 countsByYear W21615116212020 @default.
• W2161511621 countsByYear W21615116212021 @default.
• W2161511621 countsByYear W21615116212022 @default.
• W2161511621 crossrefType "journal-article" @default.
• W2161511621 hasAuthorship W2161511621A5011581277 @default.
• W2161511621 hasAuthorship W2161511621A5035791716 @default.
• W2161511621 hasAuthorship W2161511621A5071041099 @default.
• W2161511621 hasAuthorship W2161511621A5082694156 @default.
• W2161511621 hasAuthorship W2161511621A5091285288 @default.
• W2161511621 hasConcept C108625454 @default.
• W2161511621 hasConcept C112705442 @default.
• W2161511621 hasConcept C11569505 @default.
• W2161511621 hasConcept C165616093 @default.
• W2161511621 hasConcept C170493617 @default.
• W2161511621 hasConcept C185592680 @default.
• W2161511621 hasConcept C202751555 @default.
• W2161511621 hasConcept C2776125364 @default.
• W2161511621 hasConcept C2776200302 @default.
• W2161511621 hasConcept C2776841590 @default.
• W2161511621 hasConcept C2777807558 @default.
• W2161511621 hasConcept C2779212266 @default.
• W2161511621 hasConcept C2780758401 @default.
• W2161511621 hasConcept C55493867 @default.
• W2161511621 hasConcept C86803240 @default.
• W2161511621 hasConcept C86807702 @default.
• W2161511621 hasConcept C98274493 @default.
• W2161511621 hasConceptScore W2161511621C108625454 @default.
• W2161511621 hasConceptScore W2161511621C112705442 @default.
• W2161511621 hasConceptScore W2161511621C11569505 @default.
• W2161511621 hasConceptScore W2161511621C165616093 @default.
• W2161511621 hasConceptScore W2161511621C170493617 @default.
• W2161511621 hasConceptScore W2161511621C185592680 @default.
• W2161511621 hasConceptScore W2161511621C202751555 @default.
• W2161511621 hasConceptScore W2161511621C2776125364 @default.
• W2161511621 hasConceptScore W2161511621C2776200302 @default.

• next