FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161514862> ?p ?o ?g. }

• W2161514862 endingPage "117" @default.
• W2161514862 startingPage "109" @default.
• W2161514862 abstract "Selenomethionine (SeMet) is being tested alone and in combination with other agents in cancer chemoprevention trials. However, the molecular targets and the signaling mechanism underlying the anticancer effect of this compound are not completely clear. Here, we provide evidence that SeMet can induce cell-growth arrest and that the growth inhibition is associated with S-G2/M cell-cycle arrest. Coincidentally with the cell-cycle arrest, we observed a striking increase in cyclin B as well as phosphorylation of the cyclin-dependent kinase Cdc2. Since activation of the mitogen-activated protein kinase (MAPK) cascade has been associated with cell-cycle arrest and growth inhibition, we evaluated the activation of extracellular signal-regulated kinase (ERK). We found that SeMet induced phosphorylation of the MAPK ERK in a dose-dependent manner. We also demonstrate phosphorylation of ribosomal S6 kinase (p90RSK) by SeMet. Additionally, we show phosphorylation of histone H3 in a concentration-dependent manner. Furthermore, the phosphorylation of p90RSK and histone H3 were both antagonized by the MEK inhibitor U0126, implying that SeMet-induced phosphorylation of p90RSK and histone H3 are at least in part ERK pathway dependent. Based on these results, we propose that SeMet induced growth arrest and phosphorylation of histone H3 are mediated by persistent ERK and p90RSK activation. These new data provide valuable insights into the biological effects of SeMet at clinically relevant concentrations." @default.
• W2161514862 created "2016-06-24" @default.
• W2161514862 creator A5028993570 @default.
• W2161514862 creator A5077699431 @default.
• W2161514862 creator A5080504429 @default.
• W2161514862 creator A5091061674 @default.
• W2161514862 date "2004-06-24" @default.
• W2161514862 modified "2023-09-27" @default.
• W2161514862 title "Selenomethionine induces sustained ERK phosphorylation leading to cell-cycle arrest in human colon cancer cells" @default.
• W2161514862 cites W1678344239 @default.
• W2161514862 cites W1768273339 @default.
• W2161514862 cites W1781374595 @default.
• W2161514862 cites W1904486154 @default.
• W2161514862 cites W1922521877 @default.
• W2161514862 cites W1939611276 @default.
• W2161514862 cites W1963995727 @default.
• W2161514862 cites W1968461085 @default.
• W2161514862 cites W1970514960 @default.
• W2161514862 cites W1973704051 @default.
• W2161514862 cites W1974302097 @default.
• W2161514862 cites W1978626016 @default.
• W2161514862 cites W1982776595 @default.
• W2161514862 cites W1996225161 @default.
• W2161514862 cites W2002698073 @default.
• W2161514862 cites W2003622639 @default.
• W2161514862 cites W2005330201 @default.
• W2161514862 cites W2014441588 @default.
• W2161514862 cites W2014887448 @default.
• W2161514862 cites W2026802787 @default.
• W2161514862 cites W2029524330 @default.
• W2161514862 cites W2030045479 @default.
• W2161514862 cites W2039568202 @default.
• W2161514862 cites W2039800013 @default.
• W2161514862 cites W2040375560 @default.
• W2161514862 cites W2042439588 @default.
• W2161514862 cites W2046076918 @default.
• W2161514862 cites W2048109276 @default.
• W2161514862 cites W2058680827 @default.
• W2161514862 cites W2066607735 @default.
• W2161514862 cites W2067670440 @default.
• W2161514862 cites W2073460338 @default.
• W2161514862 cites W2086673710 @default.
• W2161514862 cites W2087310418 @default.
• W2161514862 cites W2096025183 @default.
• W2161514862 cites W2107647287 @default.
• W2161514862 cites W2107972234 @default.
• W2161514862 cites W2120924736 @default.
• W2161514862 cites W2125624250 @default.
• W2161514862 cites W2137803526 @default.
• W2161514862 cites W2141452262 @default.
• W2161514862 cites W2147669805 @default.
• W2161514862 cites W2147971204 @default.
• W2161514862 cites W2150301412 @default.
• W2161514862 cites W2159895537 @default.
• W2161514862 cites W2161327412 @default.
• W2161514862 cites W2163751122 @default.
• W2161514862 cites W2168231749 @default.
• W2161514862 cites W2169210449 @default.
• W2161514862 cites W2169536330 @default.
• W2161514862 cites W2169790726 @default.
• W2161514862 cites W2182287971 @default.
• W2161514862 cites W2321845872 @default.
• W2161514862 cites W2336715068 @default.
• W2161514862 cites W2528869668 @default.
• W2161514862 cites W2138872157 @default.
• W2161514862 cites W74093752 @default.
• W2161514862 doi "https://doi.org/10.1093/carcin/bgh306" @default.
• W2161514862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15513932" @default.
• W2161514862 hasPublicationYear "2004" @default.
• W2161514862 type Work @default.
• W2161514862 sameAs 2161514862 @default.
• W2161514862 citedByCount "44" @default.
• W2161514862 countsByYear W21615148622012 @default.
• W2161514862 countsByYear W21615148622013 @default.
• W2161514862 countsByYear W21615148622014 @default.
• W2161514862 countsByYear W21615148622015 @default.
• W2161514862 countsByYear W21615148622016 @default.
• W2161514862 countsByYear W21615148622017 @default.
• W2161514862 countsByYear W21615148622018 @default.
• W2161514862 countsByYear W21615148622021 @default.
• W2161514862 countsByYear W21615148622022 @default.
• W2161514862 crossrefType "journal-article" @default.
• W2161514862 hasAuthorship W2161514862A5028993570 @default.
• W2161514862 hasAuthorship W2161514862A5077699431 @default.
• W2161514862 hasAuthorship W2161514862A5080504429 @default.
• W2161514862 hasAuthorship W2161514862A5091061674 @default.
• W2161514862 hasBestOaLocation W21615148621 @default.
• W2161514862 hasConcept C104202773 @default.
• W2161514862 hasConcept C104317684 @default.
• W2161514862 hasConcept C105696609 @default.
• W2161514862 hasConcept C11960822 @default.
• W2161514862 hasConcept C120504264 @default.
• W2161514862 hasConcept C1491633281 @default.
• W2161514862 hasConcept C184235292 @default.
• W2161514862 hasConcept C185592680 @default.
• W2161514862 hasConcept C2776745794 @default.
• W2161514862 hasConcept C2780044377 @default.
• W2161514862 hasConcept C29537977 @default.

• next